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    QSER1 glutamine and serine rich 1 [ Homo sapiens (human) ]

    Gene ID: 79832, updated on 28-Oct-2024

    Summary

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    Official Symbol
    QSER1provided by HGNC
    Official Full Name
    glutamine and serine rich 1provided by HGNC
    Primary source
    HGNC:HGNC:26154
    See related
    Ensembl:ENSG00000060749 MIM:619440; AllianceGenome:HGNC:26154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See QSER1 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32892811..32980270)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33028395..33115866)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32914357..33001816)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:32912708-32913282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4568 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32968504-32968654 Neighboring gene uncharacterized LOC105376615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33022947-33023448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33060521-33061068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:33071407-33071907 Neighboring gene DEP domain containing 7 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33082368-33083567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33089797-33090298 Neighboring gene t-complex 11 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. QSER1 protects DNA methylation valleys from de novo methylation. Dixon G, et al. Science, 2021 Apr 9. PMID 33833093, Free PMC Article
    2. Genomewide association study for onset age in Parkinson disease. Latourelle JC, et al. BMC Med Genet, 2009 Sep 22. PMID 19772629, Free PMC Article
    3. Identification of the BRD1 interaction network and its impact on mental disorder risk. Fryland T, et al. Genome Med, 2016 May 3. PMID 27142060, Free PMC Article
    4. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Béguelin W, et al. Cancer Cell, 2016 Aug 8. PMID 27505670, Free PMC Article
    5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. QSER1 protects DNA methylation valleys from de novo methylation.
      Title: QSER1 protects DNA methylation valleys from de novo methylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomewide association study for onset age in Parkinson disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21924

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamine and serine-rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076786.3 → NP_001070254.2  glutamine and serine-rich protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107939, AK025577, AK126023, AL035400, AL834141, BC112935
      Consensus CDS
      CCDS41631.2
      UniProtKB/Swiss-Prot
      Q2KHR3, Q6ZU30, Q6ZUR5
      UniProtKB/TrEMBL
      A0A3B3IRW6
      Related
      ENSP00000496900.1, ENST00000650167.2

    2. NM_001416036.1 → NP_001402965.1  glutamine and serine-rich protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107939, AL035400

    3. NM_001416037.1 → NP_001402966.1  glutamine and serine-rich protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107939, AL035400

    4. NM_001416038.1 → NP_001402967.1  glutamine and serine-rich protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107939, AL035400

    5. NM_001416039.1 → NP_001402968.1  glutamine and serine-rich protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107939, AL035400

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      32892811..32980270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427611.1 → XP_047283567.1  glutamine and serine-rich protein 1 isoform X1

    2. XM_017018330.2 → XP_016873819.2  glutamine and serine-rich protein 1 isoform X2

    3. XM_047427613.1 → XP_047283569.1  glutamine and serine-rich protein 1 isoform X3

    4. XM_047427614.1 → XP_047283570.1  glutamine and serine-rich protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      33028395..33115866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369989.1 → XP_054225964.1  glutamine and serine-rich protein 1 isoform X1

    2. XM_054369990.1 → XP_054225965.1  glutamine and serine-rich protein 1 isoform X2

    3. XM_054369991.1 → XP_054225966.1  glutamine and serine-rich protein 1 isoform X3

    4. XM_054369992.1 → XP_054225967.1  glutamine and serine-rich protein 1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024774.2: Suppressed sequence

      Description
      NM_024774.2: This RefSeq was temporarily suppressed because there was a mismatch compared to available sequence data that resulted in premature translation termination. The C-terminus of the corrected protein is not supported by
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KHR3.3 GenPept UniProtKB/Swiss-Prot:Q2KHR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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