SOX5 SRY-box transcription factor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SOX5provided by HGNC
Official Full Name: SRY-box transcription factor 5provided by HGNC
Primary source: HGNC:HGNC:11201
See related: Ensembl:ENSG00000134532 MIM:604975; AllianceGenome:HGNC:11201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L-SOX5; LAMSHF; L-SOX5B; L-SOX5F
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 2.2), brain (RPKM 1.6) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p12.1

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (23529504..24562650, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (23401301..24433529, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (23682438..24715425, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
Title: Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
Title: EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
Title: circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
Title: SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
Title: LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
Title: miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
Title: LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
Title: Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
Title: Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
High expression levels and localization of Sox5 in dilated cardiomyopathy.
Title: High expression levels and localization of Sox5 in dilated cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Lamb-Shaffer syndrome MedGen: C4225202 OMIM: 616803 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2016-08-19) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2016-08-19) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association of lipid-lowering response to statins in combined study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of PR interval. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62804 (e-PCR)
- UniSTS:139779

SHGC-80033 (e-PCR)
- UniSTS:101645

SHGC-148450 (e-PCR)
- UniSTS:176402

SHGC-108028 (e-PCR)
- UniSTS:170522

SHGC-107736 (e-PCR)
- UniSTS:173857

SHGC-85675 (e-PCR)
- UniSTS:103719

WI-3881 (e-PCR)
- UniSTS:7208

RH80811 (e-PCR)
- UniSTS:84015

D12S1822 (e-PCR)
- UniSTS:26439

SHGC-155005 (e-PCR)
- UniSTS:182602

RH45463 (e-PCR)
- UniSTS:48716

G62989 (e-PCR)
- UniSTS:140114

SHGC-155556 (e-PCR)
- UniSTS:182619

G35318 (e-PCR)
- UniSTS:54368

G63683 (e-PCR)
- UniSTS:140645

STS-H73926 (e-PCR)
- UniSTS:82022

SHGC-106422 (e-PCR)
- UniSTS:169833

RH103584 (e-PCR)
- UniSTS:97909

SHGC-79400 (e-PCR)
- UniSTS:103290

Sox5 (e-PCR), detects polymorphism
- UniSTS:265085

Sox5 (e-PCR), detects polymorphism
- UniSTS:265086

SHGC-84176 (e-PCR)
- UniSTS:182658

D12S1942 (e-PCR)
- UniSTS:60291

G63717 (e-PCR)
- UniSTS:140678

G19258 (e-PCR)
- UniSTS:55686

RH120347 (e-PCR)
- UniSTS:132487

SHGC-155690 (e-PCR)
- UniSTS:185226

G60361 (e-PCR)
- UniSTS:137617

D12S1057 (e-PCR), detects polymorphism
- UniSTS:11936

RH45564 (e-PCR)
- UniSTS:22690

STS-N27112 (e-PCR)
- UniSTS:28330

D12S292 (e-PCR)
- UniSTS:21422

RH80021 (e-PCR)
- UniSTS:92593

G62747 (e-PCR)
- UniSTS:139724

SHGC-146191 (e-PCR)
- UniSTS:175069

G17656 (e-PCR)
- UniSTS:30950

WI-18056 (e-PCR)
- UniSTS:20214

D12S1591 (e-PCR), detects polymorphism
- UniSTS:49401

G62383 (e-PCR)
- UniSTS:139262

D12S1950 (e-PCR)
- UniSTS:60415

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mesenchymal stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor SOX-5

Names: SRY (sex determining region Y)-box 5; SRY-box 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029612.2 RefSeqGene

Range

617777..1037943

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001261414.3 → NP_001248343.1 transcription factor SOX-5 isoform d

See identical proteins and their annotated locations for NP_001248343.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AB081589, AC087244, BC060773, BM988193, BX098902, DA343699

Consensus CDS

CCDS58216.1

UniProtKB/Swiss-Prot

P35711

Related

ENSP00000493866.1, ENST00000646273.1

Conserved Domains (1) summary

cd01388
Location:434 → 505

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001261415.3 → NP_001248344.1 transcription factor SOX-5 isoform e

See identical proteins and their annotated locations for NP_001248344.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate first exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AB081589, AC087244, AK303970, BM988193, BX098902

Consensus CDS

CCDS58217.1

UniProtKB/Swiss-Prot

P35711

Related

ENSP00000443520.1, ENST00000545921.5

Conserved Domains (1) summary

cd01388
Location:545 → 616

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001330785.2 → NP_001317714.1 transcription factor SOX-5 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (f) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

AB081588, AC087244, BM988193, BX098902, DR003434

Consensus CDS

CCDS81672.1

UniProtKB/TrEMBL

F5H0I3

Related

ENSP00000439832.1, ENST00000537393.5

Conserved Domains (1) summary

cd01388
Location:520 → 591

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_006940.6 → NP_008871.3 transcription factor SOX-5 isoform a

See identical proteins and their annotated locations for NP_008871.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a, also called L-SOX5A).

Source sequence(s)

AB081589, AC087244, BM988193, BX098902

Consensus CDS

CCDS8699.1

UniProtKB/Swiss-Prot

B7Z8V0, F5H5B0, P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4

Related

ENSP00000398273.2, ENST00000451604.7

Conserved Domains (1) summary

cd01388
Location:555 → 626

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_152989.5 → NP_694534.1 transcription factor SOX-5 isoform b

See identical proteins and their annotated locations for NP_694534.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also called L-SOX5B) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AB081588, AC087244, BC060773, BM988193, BX098902, DA343699

UniProtKB/TrEMBL

T2CYZ2

Conserved Domains (1) summary

cd01388
Location:542 → 613

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_178010.4 → NP_821078.1 transcription factor SOX-5 isoform c

See identical proteins and their annotated locations for NP_821078.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate first exon in place of much of the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AB081589, AC087244, AK098610, BM988193, BX098902

Consensus CDS

CCDS41761.1

UniProtKB/TrEMBL

Q53EV3

Related

ENSP00000379328.2, ENST00000396007.6

Conserved Domains (1) summary

cd01388
Location:169 → 240

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

23529504..24562650 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024449159.2 → XP_024304927.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_024449158.2 → XP_024304926.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429458.1 → XP_047285414.1 transcription factor SOX-5 isoform X10
XM_017019891.2 → XP_016875380.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429461.1 → XP_047285417.1 transcription factor SOX-5 isoform X10
XM_017019892.2 → XP_016875381.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429457.1 → XP_047285413.1 transcription factor SOX-5 isoform X10
XM_024449157.2 → XP_024304925.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017019893.2 → XP_016875382.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_024449154.2 → XP_024304922.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011520835.3 → XP_011519137.1 transcription factor SOX-5 isoform X10

See identical proteins and their annotated locations for XP_011519137.1

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017019890.2 → XP_016875379.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429459.1 → XP_047285415.1 transcription factor SOX-5 isoform X10
XM_024449153.2 → XP_024304921.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429460.1 → XP_047285416.1 transcription factor SOX-5 isoform X10
XM_024449150.2 → XP_024304918.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429456.1 → XP_047285412.1 transcription factor SOX-5 isoform X10
XM_024449151.2 → XP_024304919.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017019894.2 → XP_016875383.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429462.1 → XP_047285418.1 transcription factor SOX-5 isoform X10
XM_047429465.1 → XP_047285421.1 transcription factor SOX-5 isoform X13

Related

ENSP00000515823.1, ENST00000704299.1
XM_047429464.1 → XP_047285420.1 transcription factor SOX-5 isoform X12
XM_011520833.3 → XP_011519135.1 transcription factor SOX-5 isoform X7

See identical proteins and their annotated locations for XP_011519135.1

Conserved Domains (1) summary

cd01388
Location:546 → 617

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_047429455.1 → XP_047285411.1 transcription factor SOX-5 isoform X9
XM_047429454.1 → XP_047285410.1 transcription factor SOX-5 isoform X8
XM_047429453.1 → XP_047285409.1 transcription factor SOX-5 isoform X6
XM_047429452.1 → XP_047285408.1 transcription factor SOX-5 isoform X5
XM_017019889.2 → XP_016875378.1 transcription factor SOX-5 isoform X4
XM_017019888.2 → XP_016875377.1 transcription factor SOX-5 isoform X3
XM_047429451.1 → XP_047285407.1 transcription factor SOX-5 isoform X2
XM_011520832.3 → XP_011519134.2 transcription factor SOX-5 isoform X1
XM_047429463.1 → XP_047285419.1 transcription factor SOX-5 isoform X11

UniProtKB/TrEMBL

T2CYZ2
XM_017019895.2 → XP_016875384.1 transcription factor SOX-5 isoform X10

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011520837.3 → XP_011519139.1 transcription factor SOX-5 isoform X10

See identical proteins and their annotated locations for XP_011519139.1

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017019903.2 → XP_016875392.2 transcription factor SOX-5 isoform X15

Related

ENSP00000515822.1, ENST00000704298.1
XM_017019902.2 → XP_016875391.2 transcription factor SOX-5 isoform X14
XM_047429466.1 → XP_047285422.1 transcription factor SOX-5 isoform X16

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

23401301..24433529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054373061.1 → XP_054229036.1 transcription factor SOX-5 isoform X10
XM_054373073.1 → XP_054229048.1 transcription factor SOX-5 isoform X10
XM_054373070.1 → XP_054229045.1 transcription factor SOX-5 isoform X10
XM_054373069.1 → XP_054229044.1 transcription factor SOX-5 isoform X10
XM_054373064.1 → XP_054229039.1 transcription factor SOX-5 isoform X10
XM_054373068.1 → XP_054229043.1 transcription factor SOX-5 isoform X10
XM_054373075.1 → XP_054229050.1 transcription factor SOX-5 isoform X10
XM_054373067.1 → XP_054229042.1 transcription factor SOX-5 isoform X10
XM_054373071.1 → XP_054229046.1 transcription factor SOX-5 isoform X10
XM_054373060.1 → XP_054229035.1 transcription factor SOX-5 isoform X10
XM_054373072.1 → XP_054229047.1 transcription factor SOX-5 isoform X10
XM_054373065.1 → XP_054229040.1 transcription factor SOX-5 isoform X10
XM_054373074.1 → XP_054229049.1 transcription factor SOX-5 isoform X10
XM_054373062.1 → XP_054229037.1 transcription factor SOX-5 isoform X10
XM_054373066.1 → XP_054229041.1 transcription factor SOX-5 isoform X10
XM_054373063.1 → XP_054229038.1 transcription factor SOX-5 isoform X10
XM_054373076.1 → XP_054229051.1 transcription factor SOX-5 isoform X10
XM_054373054.1 → XP_054229029.1 transcription factor SOX-5 isoform X4
XM_054373053.1 → XP_054229028.1 transcription factor SOX-5 isoform X3
XM_054373052.1 → XP_054229027.1 transcription factor SOX-5 isoform X2
XM_054373081.1 → XP_054229056.1 transcription factor SOX-5 isoform X13
XM_054373080.1 → XP_054229055.1 transcription factor SOX-5 isoform X12
XM_054373057.1 → XP_054229032.1 transcription factor SOX-5 isoform X7
XM_054373059.1 → XP_054229034.1 transcription factor SOX-5 isoform X9
XM_054373058.1 → XP_054229033.1 transcription factor SOX-5 isoform X8
XM_054373056.1 → XP_054229031.1 transcription factor SOX-5 isoform X6
XM_054373055.1 → XP_054229030.1 transcription factor SOX-5 isoform X5
XM_054373051.1 → XP_054229026.1 transcription factor SOX-5 isoform X1
XM_054373079.1 → XP_054229054.1 transcription factor SOX-5 isoform X11

UniProtKB/TrEMBL

T2CYZ2
XM_054373078.1 → XP_054229053.1 transcription factor SOX-5 isoform X10
XM_054373077.1 → XP_054229052.1 transcription factor SOX-5 isoform X10
XM_054373083.1 → XP_054229058.1 transcription factor SOX-5 isoform X15
XM_054373082.1 → XP_054229057.1 transcription factor SOX-5 isoform X14
XM_054373084.1 → XP_054229059.1 transcription factor SOX-5 isoform X16