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    Trim44 tripartite motif-containing 44 [ Mus musculus (house mouse) ]

    Gene ID: 80985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim44provided by MGI
    Official Full Name
    tripartite motif-containing 44provided by MGI
    Primary source
    MGI:MGI:1931835
    See related
    Ensembl:ENSMUSG00000027189 AllianceGenome:MGI:1931835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mc7; Dipb
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of protein K48-linked ubiquitination; positive regulation of defense response to virus by host; and positive regulation of signal transduction. Predicted to be active in cytoplasm. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human TRIM44 (tripartite motif containing 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 39.5), CNS E18 (RPKM 31.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim44 in Genome Data Viewer
    Location:
    2 E2; 2 54.13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102130464..102231541, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102300119..102400900, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13866 Neighboring gene predicted gene, 34268 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:102099355-102099721 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:102099850-102100051 Neighboring gene STARR-positive B cell enhancer ABC_E11148 Neighboring gene STARR-seq mESC enhancer starr_05250 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 52521 Neighboring gene STARR-positive B cell enhancer ABC_E3386 Neighboring gene STARR-seq mESC enhancer starr_05251 Neighboring gene STARR-seq mESC enhancer starr_05252 Neighboring gene predicted gene, 39890 Neighboring gene four jointed box 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis. Wu L, et al. J Mol Med (Berl), 2023 Jun. PMID 37119283
    2. TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism. He H, et al. Int J Mol Sci, 2024 Apr 23. PMID 38731834, Free PMC Article
    3. Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma. Bai J, et al. Cell Mol Biol (Noisy-le-grand), 2022 Jun 30. PMID 36227676
    4. Isolation of a mouse brain cDNA expressed in developing neuroblasts and mature neurons. Boutou E, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165382
    5. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. Urano T, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19358823

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism.
      Title: TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism.
    2. TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.
      Title: TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.
    3. Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.
      Title: Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.
    4. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
      Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102054

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 44
    Names
    DIPB
    brain cDNA 7
    protein Mc7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020267.3 → NP_064663.2  tripartite motif-containing protein 44

      See identical proteins and their annotated locations for NP_064663.2

      Status: VALIDATED

      Source sequence(s)
      AL691444
      Consensus CDS
      CCDS16466.1
      UniProtKB/Swiss-Prot
      Q80SV9, Q9JHR8, Q9QXA7
      UniProtKB/TrEMBL
      Q4KMS1
      Related
      ENSMUSP00000099633.2, ENSMUST00000102573.8
      Conserved Domains (1) summary
      pfam00643
      Location:177 → 216
      zf-B_box; B-box zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102130464..102231541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029448.1: Suppressed sequence

      Description
      NM_029448.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXA7.2 GenPept UniProtKB/Swiss-Prot:Q9QXA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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