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    PBK PDZ binding kinase [ Homo sapiens (human) ]

    Gene ID: 55872, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PBKprovided by HGNC
    Official Full Name
    PDZ binding kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:18282
    See related
    Ensembl:ENSG00000168078 MIM:611210; AllianceGenome:HGNC:18282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPK; CT84; TOPK; HEL164; Nori-3
    Summary
    This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PBK in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27809624..27837817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28086996..28115148, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27667141..27695334, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986934 Neighboring gene uncharacterized LOC124902093 Neighboring gene coiled-coil domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19051 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27158 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27735141-27735642 Neighboring gene scavenger receptor class A member 5 Neighboring gene microRNA 4287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma. Ohashi T, et al. Br J Cancer, 2017 Jan 17. PMID 27898655, Free PMC Article
    2. T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma. Thanindratarn P, et al. Mol Oncol, 2021 Dec. PMID 34115928, Free PMC Article
    3. PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study. Yu WN, et al. Anticancer Res, 2021 Apr. PMID 33813430
    4. PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion. Brown-Clay JD, et al. Oncotarget, 2015 Jun 20. PMID 25909225, Free PMC Article
    5. PBK expression predicts favorable survival in colorectal cancer patients. Nagano-Matsuo A, et al. Virchows Arch, 2021 Aug. PMID 33638656

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.
      Title: TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.
    2. KRAS[G12C] mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.
      Title: KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.
    3. TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.
      Title: TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.
    4. TOPK inhibits TNF-alpha-induced granulosa cell apoptosis via regulation of SIRT1/p53.
      Title: TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53.
    5. PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.
      Title: PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.
    6. Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis.
      Title: Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis.
    7. PBK drives PARP inhibitor resistance through the TRIM37/NFkappaB axis in ovarian cancer.
      Title: PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
    8. TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.
      Title: TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.
    9. TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
      Title: TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
    10. Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.
      Title: Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (88)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lymphokine-activated killer T-cell-originated protein kinase
    Names
    MAPKK-like protein kinase
    T-LAK cell-originated protein kinase
    cancer/testis antigen 84
    epididymis luminal protein 164
    serine/threonine protein kinase
    spermatogenesis-related protein kinase
    NP_001265874.1
    NP_001349969.1
    NP_060962.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278945.2 → NP_001265874.1  lymphokine-activated killer T-cell-originated protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001265874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1.
      Source sequence(s)
      AK301836, BC015191, DB028500
      Consensus CDS
      CCDS64858.1
      UniProtKB/Swiss-Prot
      Q96KB5
      Related
      ENSP00000428489.1, ENST00000522944.5
      Conserved Domains (2) summary
      cd14001
      Location:32 → 332
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
      pfam00069
      Location:34 → 327
      Pkinase; Protein kinase domain

    2. NM_001363040.2 → NP_001349969.1  lymphokine-activated killer T-cell-originated protein kinase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC015191, DC395891
      Consensus CDS
      CCDS6063.1
      UniProtKB/Swiss-Prot
      B4DX68, D3DST2, Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6
      UniProtKB/TrEMBL
      V9HWH0
      Conserved Domains (1) summary
      cd14001
      Location:32 → 321
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    3. NM_018492.4 → NP_060962.2  lymphokine-activated killer T-cell-originated protein kinase isoform 1

      See identical proteins and their annotated locations for NP_060962.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the shorter isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC015191, DB028500
      Consensus CDS
      CCDS6063.1
      UniProtKB/Swiss-Prot
      B4DX68, D3DST2, Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6
      UniProtKB/TrEMBL
      V9HWH0
      Related
      ENSP00000301905.4, ENST00000301905.9
      Conserved Domains (1) summary
      cd14001
      Location:32 → 321
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      27809624..27837817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28086996..28115148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KB5.3 GenPept UniProtKB/Swiss-Prot:Q96KB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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