Pltp phospholipid transfer protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pltpprovided by MGI
Official Full Name: phospholipid transfer proteinprovided by MGI
Primary source: MGI:MGI:103151
See related: Ensembl:ENSMUSG00000017754 AllianceGenome:MGI:103151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bpife; OD107
Summary: Enables lipid transfer activity. Acts upstream of or within flagellated sperm motility and vitamin E biosynthetic process. Located in extracellular space. Is expressed in several structures, including bone marrow; central nervous system; genitourinary system; humerus cartilage condensation; and oral region epithelium. Used to study dry eye syndrome. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in lung adult (RPKM 368.4), subcutaneous fat pad adult (RPKM 153.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.27 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164681441..164699564, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164839518..164857708, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.
Title: C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.
Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS.
Title: Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS.
Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models.
Title: Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models.
Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.
Title: Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.
Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.
Title: Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.
Disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice.
Title: Disruption of Phospholipid Transfer Protein-Mediated High-Density Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency-Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications.
The selected compounds were further confirmed to target PLTP both biochemically and biophysically and were shown to inhibit apoB secretion from hepatic cells with no apparent toxicity.
Title: Identification of Novel Phospholipid Transfer Protein Inhibitors by High-Throughput Screening.
PLTP-/- mice were protected from high-fat-diet-induced obesity and insulin resistance, compared with wild type mice.
Title: Phospholipid transfer protein (PLTP) deficiency attenuates high fat diet induced obesity and insulin resistance.
Profurin can interact with intracellular PLTP and promote its ubiquitination and proteasomal degradation, resulting in less PLTP secretion from the hepatocytes. Furin does not cleave PLTP; instead, it forms a complex with PLTP, likely through its prodomain
Title: Prodomain of Furin Promotes Phospholipid Transfer Protein Proteasomal Degradation in Hepatocytes.
these data show that PLTP plays a role in modulating the adaptive immune response toward a pro-inflammatory phenotype, which may be an additional contributor to its pro-atherogenic effects
Title: Plasma phospholipid transfer protein (PLTP) as an emerging determinant of the adaptive immune response.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pltp (e-PCR), detects polymorphism
- UniSTS:498481

U37226 (e-PCR)
- UniSTS:178763

J05261 (e-PCR)
- UniSTS:178768

Pltp (e-PCR), detects polymorphism
- UniSTS:527496

RH136414 (e-PCR)
- UniSTS:210404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide binding	IEA Inferred from Electronic Annotation more info
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables ceramide transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cerebroside transfer activity	IEA Inferred from Electronic Annotation more info
enables cerebroside transfer activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables diacylglyceride transfer activity	IEA Inferred from Electronic Annotation more info
enables diacylglyceride transfer activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid transfer activity	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylethanolamine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol transfer activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerol transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid transfer activity	ISO Inferred from Sequence Orthology more info
enables sphingomyelin transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sphingomyelin transfer activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide transport	IEA Inferred from Electronic Annotation more info
involved_in ceramide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolipid transport	IEA Inferred from Electronic Annotation more info
involved_in glycolipid transport	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin E biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipid transfer protein

Names: lipid transfer protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420692.1 → NP_001407621.1 phospholipid transfer protein isoform a precursor

Status: VALIDATED

Source sequence(s)

AL591495

UniProtKB/Swiss-Prot

P55065, Q99L70

UniProtKB/TrEMBL

Q3UFS5
NM_001420693.1 → NP_001407622.1 phospholipid transfer protein isoform b

Status: VALIDATED

Source sequence(s)

AL591495
NM_011125.3 → NP_035255.1 phospholipid transfer protein isoform a precursor

See identical proteins and their annotated locations for NP_035255.1

Status: VALIDATED

Source sequence(s)

AL591495

Consensus CDS

CCDS17063.1

UniProtKB/Swiss-Prot

P55065, Q99L70

UniProtKB/TrEMBL

Q3UFS5, Q4FJT5

Related

ENSMUSP00000061519.8, ENSMUST00000059954.14

Conserved Domains (2) summary

smart00328
Location:25 → 243

BPI1; BPI/LBP/CETP N-terminal domain

pfam02886
Location:228 → 464

LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain