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    CERCAM cerebral endothelial cell adhesion molecule [ Homo sapiens (human) ]

    Gene ID: 51148, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CERCAMprovided by HGNC
    Official Full Name
    cerebral endothelial cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:23723
    See related
    Ensembl:ENSG00000167123 MIM:616626; AllianceGenome:HGNC:23723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEECAM1; GLT25D3
    Summary
    Enables identical protein binding activity. Acts upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 35.8), placenta (RPKM 14.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CERCAM in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128419160..128437351)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140613098..140644454)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131181439..131199630)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131132825-131133688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29080 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131145413-131146057 Neighboring gene ubiquitin related modifier 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131147991-131148635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131155313-131156018 Neighboring gene MIR219A2 host gene Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131167036-131167836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131173621-131174240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29081 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131200897-131201070 Neighboring gene protein PAT1 homolog 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131217358-131218094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218095-131218830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218831-131219566 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131219567-131220302 Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131234689-131235190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131235191-131235690 Neighboring gene ODF2 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo. Zuo Y, et al. Cancer Med, 2021 Jul. PMID 34105305, Free PMC Article
    2. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. Starzyk RM, et al. J Infect Dis, 2000 Jan. PMID 10608765
    3. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Tyler RE, et al. Mol Biol Cell, 2012 Dec. PMID 23097496, Free PMC Article
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Apr 28. PMID 10819331
    5. TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Wang G, et al. Ann Rheum Dis, 2020 Aug. PMID 32409323, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo.
      Title: The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149620, MGC149621

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables procollagen galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukocyte cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive glycosyltransferase 25 family member 3
    Names
    cerebral cell adhesion molecule
    cerebral endothelial cell adhesion molecule 1
    glycosyltransferase 25 domain containing 3
    glycosyltransferase 25 family member 3
    probable inactive glycosyltransferase 25 family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286760.1 → NP_001273689.1  inactive glycosyltransferase 25 family member 3 isoform b

      See identical proteins and their annotated locations for NP_001273689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK314294, BC098432
      Consensus CDS
      CCDS69675.1
      UniProtKB/TrEMBL
      B4DNI4
      Conserved Domains (1) summary
      cd06532
      Location:243 → 425
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    2. NM_016174.5 → NP_057258.3  inactive glycosyltransferase 25 family member 3 isoform a precursor

      See identical proteins and their annotated locations for NP_057258.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC098432, CX871555
      Consensus CDS
      CCDS6901.2
      UniProtKB/Swiss-Prot
      A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5
      UniProtKB/TrEMBL
      B4DNI4
      Related
      ENSP00000361929.4, ENST00000372838.9
      Conserved Domains (2) summary
      cd06532
      Location:321 → 503
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
      cl11394
      Location:37 → 81
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      128419160..128437351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423450.1 → XP_047279406.1  inactive glycosyltransferase 25 family member 3 isoform X1

    2. XM_011518763.4 → XP_011517065.1  inactive glycosyltransferase 25 family member 3 isoform X1

      See identical proteins and their annotated locations for XP_011517065.1

      UniProtKB/TrEMBL
      B4DNI4
      Related
      ENSP00000361933.1, ENST00000372842.5
      Conserved Domains (1) summary
      cd06532
      Location:243 → 425
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      140613098..140644454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363062.1 → XP_054219037.1  inactive glycosyltransferase 25 family member 3 isoform X2

      UniProtKB/Swiss-Prot
      A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5

    2. XM_054363061.1 → XP_054219036.1  inactive glycosyltransferase 25 family member 3 isoform X2

      UniProtKB/Swiss-Prot
      A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5

    3. XM_054363063.1 → XP_054219038.1  inactive glycosyltransferase 25 family member 3 isoform X1

    4. XM_054363064.1 → XP_054219039.1  inactive glycosyltransferase 25 family member 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T4B2.1 GenPept UniProtKB/Swiss-Prot:Q5T4B2

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