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    Atg16l2 autophagy related 16 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 73683, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atg16l2provided by MGI
    Official Full Name
    autophagy related 16 like 2provided by MGI
    Primary source
    MGI:MGI:1920933
    See related
    Ensembl:ENSMUSG00000047767 AllianceGenome:MGI:1920933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410118P20Rik
    Summary
    Involved in autophagosome assembly. Acts upstream of or within negative stranded viral RNA replication. Located in cytosol and phagophore assembly site membrane. Part of Atg12-Atg5-Atg16 complex. Is expressed in embryo. Orthologous to human ATG16L2 (autophagy related 16 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 5.6), thymus adult (RPKM 4.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atg16l2 in Genome Data Viewer
    Location:
    7 E2; 7 54.54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100935521..100951474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101286325..101302267, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene predicted gene, 50587 Neighboring gene predicted gene, 57508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108450776-108450959 Neighboring gene STARR-seq mESC enhancer starr_19689 Neighboring gene STARR-positive B cell enhancer ABC_E1349 Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. Wang D, et al. Eur J Immunol, 2022 Aug. PMID 35426127
    2. Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1. Khor B, et al. J Immunol, 2019 Oct 1. PMID 31451676, Free PMC Article
    3. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. Li N, et al. J Clin Invest, 2013 May. PMID 23563314, Free PMC Article
    4. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. Mizushima N, et al. J Cell Biol, 2001 Feb 19. PMID 11266458, Free PMC Article
    5. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. Mizushima N, et al. J Cell Sci, 2003 May 1. PMID 12665549

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
      Title: ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy.
    2. results show that ATG16L1 and ATG16L2 contribute very distinctly to autophagy and cellular ontogeny in myeloid, lymphoid, and epithelial lineages. Dysregulation of any of these lineages could contribute to complex diseases like Crohn disease and systemic lupus erythematosus.
      Title: Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.
    3. IKKalpha, which may control autophagic protein degradation through its interaction with ATG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreatitis through p62 aggregate accumulation
      Title: Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
    4. Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.
      Title: Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative stranded viral RNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Atg12-Atg5-Atg16 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Atg16l2
    Names
    APG16-like 2
    Atg16L2 alpha
    Atg16L2 beta
    autophagy-related 16-like 2 alpha
    autophagy-related 16-like 2 beta
    autophagy-related protein 16-2
    mFLJ00012 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111111.1 → NP_001104581.1  protein Atg16l2

      See identical proteins and their annotated locations for NP_001104581.1

      Status: VALIDATED

      Source sequence(s)
      AK010773, BC060054, BP767155
      Consensus CDS
      CCDS52329.1
      UniProtKB/Swiss-Prot
      D3Z653, G9M4M8, Q6KAU8, Q6PAU0
      Related
      ENSMUSP00000112500.2, ENSMUST00000120267.9
      Conserved Domains (6) summary
      COG2319
      Location:327 → 622
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:335 → 622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08614
      Location:20 → 207
      ATG16; Autophagy protein 16 (ATG16)
      pfam16034
      Location:21 → 198
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:345 → 382
      7WD40; WD40 repeat [structural motif]
      cl02193
      Location:109 → 196
      VirB5_like; VirB5 protein family

    RNA

    1. NR_152152.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in several internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC107638
      Related
      ENSMUST00000139609.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100935521..100951474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508225.5 → XP_006508288.1  protein Atg16l2 isoform X1

      Conserved Domains (3) summary
      cd00200
      Location:338 → 539
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:348 → 385
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    2. XM_006508231.5 → XP_006508294.1  protein Atg16l2 isoform X8

      Conserved Domains (3) summary
      cd00200
      Location:359 → 560
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369 → 406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    3. XM_006508226.5 → XP_006508289.1  protein Atg16l2 isoform X3

      See identical proteins and their annotated locations for XP_006508289.1

      Related
      ENSMUSP00000113320.2, ENSMUST00000122116.8
      Conserved Domains (3) summary
      cd00200
      Location:338 → 625
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:348 → 385
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    4. XM_036153476.1 → XP_036009369.1  protein Atg16l2 isoform X5

      Conserved Domains (3) summary
      cd00200
      Location:316 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:326 → 363
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    5. XM_036153475.1 → XP_036009368.1  protein Atg16l2 isoform X2

      Conserved Domains (3) summary
      cd00200
      Location:337 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:347 → 384
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    6. XM_011241916.4 → XP_011240218.1  protein Atg16l2 isoform X6

      Conserved Domains (3) summary
      cd00200
      Location:359 → 560
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369 → 406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    7. XM_006508227.5 → XP_006508290.1  protein Atg16l2 isoform X4

      Conserved Domains (3) summary
      cd00200
      Location:359 → 616
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369 → 406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59 → 231
      ATG16; Autophagy protein 16 (ATG16)

    8. XM_036153477.1 → XP_036009370.1  protein Atg16l2 isoform X9

      Conserved Domains (3) summary
      cd00200
      Location:204 → 405
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:214 → 251
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    9. XM_006508228.3 → XP_006508291.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_006508291.1

      Conserved Domains (4) summary
      COG3064
      Location:2 → 208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235 → 272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    10. XM_030243023.2 → XP_030098883.1  protein Atg16l2 isoform X9

      Conserved Domains (3) summary
      cd00200
      Location:204 → 405
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:214 → 251
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    11. XM_011241918.3 → XP_011240220.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_011240220.1

      Conserved Domains (4) summary
      COG3064
      Location:2 → 208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235 → 272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    12. XM_030243022.2 → XP_030098882.1  protein Atg16l2 isoform X7

      Conserved Domains (4) summary
      COG3064
      Location:2 → 208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235 → 272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    13. XM_006508230.3 → XP_006508293.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_006508293.1

      Conserved Domains (4) summary
      COG3064
      Location:2 → 208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235 → 272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:1 → 97
      ATG16; Autophagy protein 16 (ATG16)

    RNA

    1. XR_003946569.2 RNA Sequence

    2. XR_003946571.2 RNA Sequence

    3. XR_004934191.1 RNA Sequence

    4. XR_378274.5 RNA Sequence

    5. XR_004934190.1 RNA Sequence

    6. XR_001778004.3 RNA Sequence

    7. XR_004934192.1 RNA Sequence

    8. XR_003946570.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6KAU8.2 GenPept UniProtKB/Swiss-Prot:Q6KAU8

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