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    GPHB5 glycoprotein hormone subunit beta 5 [ Homo sapiens (human) ]

    Gene ID: 122876, updated on 27-Nov-2024

    Summary

    Official Symbol
    GPHB5provided by HGNC
    Official Full Name
    glycoprotein hormone subunit beta 5provided by HGNC
    Primary source
    HGNC:HGNC:18055
    See related
    Ensembl:ENSG00000179600 MIM:609652; AllianceGenome:HGNC:18055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B5; GPB5; ZLUT1
    Summary
    GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See GPHB5 in Genome Data Viewer
    Location:
    14q23.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63312835..63318935, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57520199..57526299, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (63779549..63785649, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370530 Neighboring gene ras homolog family member J Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63764973-63765474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63765475-63765974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63799179-63799678 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34994 Neighboring gene protein phosphatase 2 regulatory subunit B'epsilon Neighboring gene Sharpr-MPRA regulatory region 14795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8504 Neighboring gene U6 spliceosomal RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8505 Neighboring gene uncharacterized LOC124900352

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyrotropin-releasing hormone receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    glycoprotein hormone beta-5
    Names
    glycoprotein beta 5
    glycoprotein hormone beta 5
    glycoprotein hormone beta subunit
    thyrostimulin subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145171.4NP_660154.3  glycoprotein hormone beta-5 precursor

      See identical proteins and their annotated locations for NP_660154.3

      Status: VALIDATED

      Source sequence(s)
      AL118555, BM709443
      Consensus CDS
      CCDS73643.1
      UniProtKB/Swiss-Prot
      Q6NTD0, Q86YW7, Q8NFW2
      UniProtKB/TrEMBL
      A0A0F7RPU1, A4IF52
      Related
      ENSP00000478993.1, ENST00000621500.2
      Conserved Domains (1) summary
      cd00069
      Location:36129
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      63312835..63318935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      57520199..57526299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)