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    UBE2M ubiquitin conjugating enzyme E2 M [ Homo sapiens (human) ]

    Gene ID: 9040, updated on 9-Dec-2024

    Summary

    Official Symbol
    UBE2Mprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Mprovided by HGNC
    Primary source
    HGNC:HGNC:12491
    See related
    Ensembl:ENSG00000130725 MIM:603173; AllianceGenome:HGNC:12491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC12; hUbc12; UBC-RS2
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 24.7), testis (RPKM 23.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBE2M in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58555712..58558611, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61653389..61656288, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59067079..59069978, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 28 Neighboring gene microRNA 6807 Neighboring gene charged multivesicular body protein 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59067095-59067778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59070738-59071334 Neighboring gene MZF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11096 Neighboring gene myeloid zinc finger 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59083407-59084268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15214 Neighboring gene CENPB DNA-binding domains containing 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59093108-59093611

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NEDD8 conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NEDD8 transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NEDD8 transferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    involved_in protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NEDD8-conjugating enzyme Ubc12
    Names
    NEDD8 carrier protein
    NEDD8 protein ligase
    epididymis secretory sperm binding protein
    ubiquitin carrier protein M
    ubiquitin conjugating enzyme E2M
    ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
    ubiquitin-protein ligase M
    yeast UBC12 homolog
    NP_003960.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003969.4NP_003960.1  NEDD8-conjugating enzyme Ubc12

      See identical proteins and their annotated locations for NP_003960.1

      Status: REVIEWED

      Source sequence(s)
      AC016630, BC058924
      Consensus CDS
      CCDS12987.1
      UniProtKB/Swiss-Prot
      O76069, P61081, Q8VC50
      UniProtKB/TrEMBL
      A0A024R4T4
      Related
      ENSP00000253023.2, ENST00000253023.8
      Conserved Domains (1) summary
      pfam00179
      Location:33168
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58555712..58558611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61653389..61656288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)