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    UBE2G2 ubiquitin conjugating enzyme E2 G2 [ Homo sapiens (human) ]

    Gene ID: 7327, updated on 9-Dec-2024

    Summary

    Official Symbol
    UBE2G2provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 G2provided by HGNC
    Primary source
    HGNC:HGNC:12483
    See related
    Ensembl:ENSG00000184787 MIM:603124; AllianceGenome:HGNC:12483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC7
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in spleen (RPKM 19.6), appendix (RPKM 19.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBE2G2 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44768580..44801820, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (43128837..43162088, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46188495..46221735, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46116947-46117626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46117627-46118306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46122289-46123024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46123025-46123760 Neighboring gene keratin associated protein 10-12 Neighboring gene keratin associated protein 10-13, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46129182-46129922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46129923-46130663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46130677-46131447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46150268-46150768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46150769-46151269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46151907-46152582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46152583-46153258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46155285-46155958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46155959-46156634 Neighboring gene Sharpr-MPRA regulatory region 5612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46184321-46184886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46185571-46186334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46186335-46187098 Neighboring gene Sharpr-MPRA regulatory region 676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46188940-46189440 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46208307-46208531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46220961-46221916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13388 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46227083-46227236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46235315-46235829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13390 Neighboring gene long intergenic non-protein coding RNA 1424 Neighboring gene small ubiquitin like modifier 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 G2
    Names
    E2 ubiquitin-conjugating enzyme G2
    ubiquitin carrier protein G2
    ubiquitin conjugating enzyme 7
    ubiquitin conjugating enzyme G2
    ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
    ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)
    ubiquitin-protein ligase G2
    NP_001189418.1
    NP_003334.2
    NP_872630.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052982.1 RefSeqGene

      Range
      5017..38257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202489.2NP_001189418.1  ubiquitin-conjugating enzyme E2 G2 isoform 3

      See identical proteins and their annotated locations for NP_001189418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL773604, BU741369, DA710059
      UniProtKB/Swiss-Prot
      P60604
      Conserved Domains (1) summary
      pfam00179
      Location:189
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_003343.6NP_003334.2  ubiquitin-conjugating enzyme E2 G2 isoform 1

      See identical proteins and their annotated locations for NP_003334.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK290629, AL773604, BC008351, BU741369
      Consensus CDS
      CCDS13714.1
      UniProtKB/Swiss-Prot
      A6NMQ7, A8K3L4, D3DSL7, P56554, P60604
      Related
      ENSP00000338348.3, ENST00000345496.7
      Conserved Domains (1) summary
      COG5078
      Location:1163
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    3. NM_182688.3NP_872630.1  ubiquitin-conjugating enzyme E2 G2 isoform 2

      See identical proteins and their annotated locations for NP_872630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK290629, AL773604, BE292782, BU741369
      Consensus CDS
      CCDS33586.1
      UniProtKB/Swiss-Prot
      P60604
      Related
      ENSP00000331384.5, ENST00000330942.9
      Conserved Domains (1) summary
      pfam00179
      Location:3131
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      44768580..44801820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      43128837..43162088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)