U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SLC27A5 solute carrier family 27 member 5 [ Homo sapiens (human) ]

    Gene ID: 10998, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC27A5provided by HGNC
    Official Full Name
    solute carrier family 27 member 5provided by HGNC
    Primary source
    HGNC:HGNC:10999
    See related
    Ensembl:ENSG00000083807 MIM:603314; AllianceGenome:HGNC:10999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2
    Summary
    The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 126.6) and testis (RPKM 2.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC27A5 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58498333..58511992, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61594402..61607985, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59009700..59023359, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268251 Neighboring gene zinc finger protein 446 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59023062-59023576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59029424-59030084 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59049840-59050470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59050471-59051099 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59054606-59055110 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22987

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables very long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
     
    involved_in bile acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bile acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in bile acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ketone body biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride mobilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 5
    Names
    BA-CoA ligase
    VLACS-related
    bile acid-CoA ligase
    bile acyl-CoA synthetase
    cholate--CoA ligase
    fatty acid transport protein 5
    fatty-acid-Coenzyme A ligase, very long-chain 3
    long-chain-fatty-acid--CoA ligase
    solute carrier family 27 (fatty acid transporter), member 5
    very long-chain acyl-CoA synthetase homolog 2
    very long-chain acyl-CoA synthetase-related protein
    NP_001308125.1
    NP_036386.1
    XP_011524666.1
    XP_016881703.1
    XP_054175600.1
    XP_054175601.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047124.1 RefSeqGene

      Range
      5074..18733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321196.2NP_001308125.1  long-chain fatty acid transport protein 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AF064255, AK298446, BU688212
      Consensus CDS
      CCDS82415.1
      UniProtKB/Swiss-Prot
      Q9Y2P5
      Related
      ENSP00000470368.1, ENST00000601355.1
      Conserved Domains (1) summary
      cl17068
      Location:146596
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. NM_012254.3NP_036386.1  long-chain fatty acid transport protein 5 isoform 1

      See identical proteins and their annotated locations for NP_036386.1

      Status: REVIEWED

      Source sequence(s)
      AK123036, BX103174
      Consensus CDS
      CCDS12983.1
      UniProtKB/Swiss-Prot
      B3KVP6, B4DPQ1, Q9Y2P5
      Related
      ENSP00000263093.2, ENST00000263093.7
      Conserved Domains (2) summary
      cd05938
      Location:140680
      hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
      PRK08279
      Location:87690
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58498333..58511992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526364.3XP_011524666.1  long-chain fatty acid transport protein 5 isoform X1

      Conserved Domains (2) summary
      pfam00501
      Location:120558
      AMP-binding; AMP-binding enzyme
      cl17068
      Location:140592
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. XM_017026214.3XP_016881703.1  long-chain fatty acid transport protein 5 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61594402..61607985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319625.1XP_054175600.1  long-chain fatty acid transport protein 5 isoform X1

    2. XM_054319626.1XP_054175601.1  long-chain fatty acid transport protein 5 isoform X2