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    RHOJ ras homolog family member J [ Homo sapiens (human) ]

    Gene ID: 57381, updated on 3-Dec-2024

    Summary

    Official Symbol
    RHOJprovided by HGNC
    Official Full Name
    ras homolog family member Jprovided by HGNC
    Primary source
    HGNC:HGNC:688
    See related
    Ensembl:ENSG00000126785 MIM:607653; AllianceGenome:HGNC:688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCL; ARHJ; TC10B; RASL7B
    Summary
    This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RHOJ in Genome Data Viewer
    Location:
    14q23.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63204443..63293508)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57411795..57500853)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (63671161..63760226)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LINE-1 retrotransposable element ORF1 protein-like Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:63632890-63633551 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:63640011-63640186 Neighboring gene uncharacterized LOC105370530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63764973-63765474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63765475-63765974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:63799179-63799678 Neighboring gene glycoprotein hormone subunit beta 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34994 Neighboring gene protein phosphatase 2 regulatory subunit B'epsilon Neighboring gene Sharpr-MPRA regulatory region 14795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8504 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14445, MGC34777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retina vasculature morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rho-related GTP-binding protein RhoJ
    Names
    RAS-like, family 7, member B
    TC10-like Rho GTPase
    ras homolog gene family, member J
    ras-like protein family member 7B
    tc10-like GTP-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020663.5NP_065714.1  rho-related GTP-binding protein RhoJ

      See identical proteins and their annotated locations for NP_065714.1

      Status: VALIDATED

      Source sequence(s)
      AF087862, AK027351, AL049871, BM555132
      Consensus CDS
      CCDS9757.1
      UniProtKB/Swiss-Prot
      Q96KC1, Q9H4E5
      UniProtKB/TrEMBL
      Q7Z513
      Related
      ENSP00000316729.3, ENST00000316754.8
      Conserved Domains (1) summary
      cl38936
      Location:22195
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      63204443..63293508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536993.4XP_011535295.1  rho-related GTP-binding protein RhoJ isoform X2

      Conserved Domains (2) summary
      smart00174
      Location:24142
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cl21455
      Location:22140
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_047431613.1XP_047287569.1  rho-related GTP-binding protein RhoJ isoform X1

      UniProtKB/TrEMBL
      G3V476
      Related
      ENSP00000451643.1, ENST00000555125.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      57411795..57500853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376446.1XP_054232421.1  rho-related GTP-binding protein RhoJ isoform X2

    2. XM_054376445.1XP_054232420.1  rho-related GTP-binding protein RhoJ isoform X1

      UniProtKB/TrEMBL
      G3V476