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    RAB32 RAB32, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 10981, updated on 28-Oct-2024

    Summary

    Official Symbol
    RAB32provided by HGNC
    Official Full Name
    RAB32, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9772
    See related
    Ensembl:ENSG00000118508 MIM:612906; AllianceGenome:HGNC:9772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARK26
    Summary
    The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
    Expression
    Broad expression in bone marrow (RPKM 49.7), spleen (RPKM 19.8) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAB32 in Genome Data Viewer
    Location:
    6q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (146543833..146554953)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (147737054..147748175)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (146864969..146876089)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 1 Neighboring gene FUN14 domain containing 2 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:146578666-146579217 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:146678820-146680019 Neighboring gene RNA, 5S ribosomal pseudogene 222 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:146709629-146710828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17644 Neighboring gene Sharpr-MPRA regulatory region 4102 Neighboring gene uncharacterized LOC124901517 Neighboring gene ADGB divergent transcript Neighboring gene androglobin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    EBI GWAS Catalog
    Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables AP-2 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables AP-3 adaptor complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables BLOC-2 complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosome to melanosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in melanosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in melanosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in early endosome lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006834.5NP_006825.1  ras-related protein Rab-32

      See identical proteins and their annotated locations for NP_006825.1

      Status: REVIEWED

      Source sequence(s)
      BC015061, BQ018663
      Consensus CDS
      CCDS5210.1
      UniProtKB/Swiss-Prot
      Q13637
      UniProtKB/TrEMBL
      B2R5I8
      Related
      ENSP00000356465.3, ENST00000367495.4
      Conserved Domains (1) summary
      cd04107
      Location:26224
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      146543833..146554953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      147737054..147748175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)