Gtpbp10 GTP-binding protein 10 (putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtpbp10provided by MGI
Official Full Name: GTP-binding protein 10 (putative)provided by MGI
Primary source: MGI:MGI:2385599
See related: Ensembl:ENSMUSG00000040464 AllianceGenome:MGI:2385599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930545J22Rik
Summary: Predicted to enable GTP binding activity. Predicted to be involved in ribosome biogenesis. Located in mitochondrion. Is expressed in cardiovascular system; genitourinary system; gut; lung; and skin. Orthologous to human GTPBP10 (GTP binding protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 4.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.02 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (5587454..5609541, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (5537454..5559541, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357031.1 → NP_001343960.1 GTP-binding protein 10 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC026813, AC068663

Conserved Domains (1) summary

cl25666
Location:15 → 296

HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
NM_001357032.1 → NP_001343961.1 GTP-binding protein 10 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two consecutive alternate exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC026813, AC068663

UniProtKB/TrEMBL

F8WHJ2

Related

ENSMUSP00000113648.3, ENSMUST00000119521.8

Conserved Domains (2) summary

cd01898
Location:108 → 270

Obg; Obg GTPase

pfam01018
Location:16 → 106

GTP1_OBG; GTP1/OBG
NM_153116.2 → NP_694756.1 GTP-binding protein 10 isoform 1.

See identical proteins and their annotated locations for NP_694756.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC026813, AC068663, AK160252

Consensus CDS

CCDS39006.1

UniProtKB/Swiss-Prot

Q8K013

Related

ENSMUSP00000111101.3, ENSMUST00000115441.9

Conserved Domains (3) summary

cd01898
Location:149 → 343

Obg; Obg GTPase

TIGR02729
Location:15 → 343

Obg_CgtA; Obg family GTPase CgtA

pfam01018
Location:15 → 145

GTP1_OBG; GTP1/OBG