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    Flacc1 flagellum associated containing coiled-coil domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 108812, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Flacc1provided by MGI
    Official Full Name
    flagellum associated containing coiled-coil domains 1provided by MGI
    Primary source
    MGI:MGI:1918359
    See related
    Ensembl:ENSMUSG00000047528 AllianceGenome:MGI:1918359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Als2cr12; 4933405P16Rik; 4933425F06Rik
    Summary
    Located in cytoplasmic vesicle and outer dense fiber. Orthologous to human FLACC1 (flagellum associated containing coiled-coil domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 8.6), subcutaneous fat pad adult (RPKM 1.0) and 2 other tissues See more
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    Genomic context

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    See Flacc1 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58696085..58735167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58656926..58696008, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01018 Neighboring gene chromobox 3, pseudogene 7 Neighboring gene caspase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01019 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58750575-58750876 Neighboring gene STARR-positive B cell enhancer ABC_E790 Neighboring gene STARR-positive B cell enhancer ABC_E5758 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene STARR-seq mESC enhancer starr_01021 Neighboring gene STARR-seq mESC enhancer starr_01022 Neighboring gene STARR-positive B cell enhancer ABC_E1220 Neighboring gene STARR-seq mESC enhancer starr_01023 Neighboring gene predicted gene, 39646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FLACC1 is testis-specific but dispensable for fertility in mice. Chotiner JY, et al. Mol Reprod Dev, 2020 Dec. PMID 33156557, Free PMC Article
    2. Expression of a sperm flagellum component encoded by the Als2cr12 gene. Choi E, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21402173
    3. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
    4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLACC1 is testis-specific but dispensable for fertility in mice.
      Title: FLACC1 is testis-specific but dispensable for fertility in mice.
    2. FLACC1 is dispensable for viability and fertility in mouse.
      Title: FLACC1 is testis-specific but dispensable for fertility in mice.
    3. the expression of the Als2cr12 gene at the transcriptional, protein and cellular levels.
      Title: Expression of a sperm flagellum component encoded by the Als2cr12 gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer dense fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flagellum-associated coiled-coil domain-containing protein 1
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog
    amyotrophic lateral sclerosis 2 chromosome region 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347056.1 → NP_001333985.1  flagellum-associated coiled-coil domain-containing protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC112968, AC118698
      Consensus CDS
      CCDS83544.1
      UniProtKB/TrEMBL
      A0A087WNN1
      Related
      ENSMUSP00000139420.2, ENSMUST00000191565.7
      Conserved Domains (1) summary
      TIGR02169
      Location:122 → 353
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_175370.5 → NP_780579.1  flagellum-associated coiled-coil domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_780579.1

      Status: VALIDATED

      Source sequence(s)
      AK077190, AK133373
      Consensus CDS
      CCDS35581.1
      UniProtKB/Swiss-Prot
      Q8BVM7
      UniProtKB/TrEMBL
      A0A087WRU9
      Related
      ENSMUSP00000062497.8, ENSMUST00000055313.14
      Conserved Domains (1) summary
      TIGR02169
      Location:122 → 353
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58696085..58735167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495613.4 → XP_006495676.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006495676.1

      UniProtKB/TrEMBL
      A0A087WNN1
      Conserved Domains (1) summary
      TIGR02169
      Location:122 → 353
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_030255466.2 → XP_030111326.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A087WNN1
      Conserved Domains (1) summary
      TIGR02169
      Location:122 → 353
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_006495618.5 → XP_006495681.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X5

    4. XM_017321225.3 → XP_017176714.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      TIGR02168
      Location:38 → 263
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006495615.4 → XP_006495678.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A087WRU9
      Related
      ENSMUSP00000140780.2, ENSMUST00000188772.7
      Conserved Domains (1) summary
      TIGR02169
      Location:122 → 338
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    6. XM_006495617.3 → XP_006495680.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      PRK04863
      Location:180 → 244
      mukB; chromosome partition protein MukB

    RNA

    1. XR_865219.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVM7.1 GenPept UniProtKB/Swiss-Prot:Q8BVM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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