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    LGALS8 galectin 8 [ Homo sapiens (human) ]

    Gene ID: 3964, updated on 9-Dec-2024

    Summary

    Official Symbol
    LGALS8provided by HGNC
    Official Full Name
    galectin 8provided by HGNC
    Primary source
    HGNC:HGNC:6569
    See related
    Ensembl:ENSG00000116977 MIM:606099; AllianceGenome:HGNC:6569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gal-8; PCTA1; PCTA-1; Po66-CBP
    Summary
    This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LGALS8 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236518214..236552981)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235919116..235953936)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236681514..236716281)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2821 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:236528741-236529521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2822 Neighboring gene MPRA-validated peak784 silencer Neighboring gene EDAR associated via death domain Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236553124-236553300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236588023-236588524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2003 Neighboring gene NANOG hESC enhancer GRCh37_chr1:236634853-236635427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236636352-236636876 Neighboring gene Sharpr-MPRA regulatory region 2344 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236679601-236679779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2004 Neighboring gene enolase 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 1811 Neighboring gene LGALS8 antisense RNA 1 Neighboring gene MPRA-validated peak785 silencer Neighboring gene MPRA-validated peak786 silencer Neighboring gene HEAT repeat containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2825 Neighboring gene MPRA-validated peak787 silencer Neighboring gene control region 3 heart enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2005 Neighboring gene VISTA enhancer hs2135 Neighboring gene actinin alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2827 Neighboring gene ribosomal protein SA pseudogene 21 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LGALS8 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphatic endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    galectin-8
    Names
    Po66 carbohydrate binding protein
    galectin-8g
    lectin, galactoside-binding, soluble, 8
    po66 carbohydrate-binding protein
    prostate carcinoma tumor antigen 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006499.5NP_006490.3  galectin-8 isoform a

      See identical proteins and their annotated locations for NP_006490.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 4 encode the longer isoform (a).
      Source sequence(s)
      AK098613, AL359921, BC016486, DB053616
      Consensus CDS
      CCDS1611.1
      UniProtKB/TrEMBL
      F6V2D4
      Related
      ENSP00000408657.2, ENST00000450372.6
      Conserved Domains (2) summary
      smart00908
      Location:236356
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18151
      Gal-bind_lectin; Galactoside-binding lectin
    2. NM_201543.4NP_963837.1  galectin-8 isoform b

      See identical proteins and their annotated locations for NP_963837.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AL359921, BC016486, DB053616
      Consensus CDS
      CCDS1612.1
      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
      UniProtKB/TrEMBL
      Q59E97
      Related
      ENSP00000342139.6, ENST00000341872.10
      Conserved Domains (2) summary
      smart00908
      Location:194314
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18151
      Gal-bind_lectin; Galactoside-binding lectin
    3. NM_201544.4NP_963838.1  galectin-8 isoform b

      See identical proteins and their annotated locations for NP_963838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AL359921, BC016486
      Consensus CDS
      CCDS1612.1
      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
      UniProtKB/TrEMBL
      Q59E97
      Related
      ENSP00000355543.4, ENST00000366584.9
      Conserved Domains (2) summary
      smart00908
      Location:194314
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18151
      Gal-bind_lectin; Galactoside-binding lectin
    4. NM_201545.2NP_963839.1  galectin-8 isoform a

      See identical proteins and their annotated locations for NP_963839.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode a longer isoform (a).
      Source sequence(s)
      AK098613, AL359921, BC016486, BP371701
      Consensus CDS
      CCDS1611.1
      UniProtKB/TrEMBL
      F6V2D4
      Related
      ENSP00000309576.2, ENST00000352231.6
      Conserved Domains (2) summary
      smart00908
      Location:236356
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18151
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      236518214..236552981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420410.1XP_047276366.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      F6V2D4
      Related
      ENSP00000435460.1, ENST00000526589.5
    2. XM_047420411.1XP_047276367.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      F6V2D4
    3. XM_047420409.1XP_047276365.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      F6V2D4
    4. XM_047420416.1XP_047276372.1  galectin-8 isoform X3

      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
      UniProtKB/TrEMBL
      Q59E97
    5. XM_011544188.4XP_011542490.1  galectin-8 isoform X2

      Conserved Domains (2) summary
      smart00908
      Location:236310
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18151
      Gal-bind_lectin; Galactoside-binding lectin
    6. XM_017001274.3XP_016856763.1  galectin-8 isoform X4

      UniProtKB/TrEMBL
      E9PN19

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      235919116..235953936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336565.1XP_054192540.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      Q59E97
    2. XM_054336566.1XP_054192541.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      Q59E97
    3. XM_054336564.1XP_054192539.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      Q59E97
    4. XM_054336567.1XP_054192542.1  galectin-8 isoform X3

      UniProtKB/TrEMBL
      Q59E97