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    SLCO3A1 solute carrier organic anion transporter family member 3A1 [ Homo sapiens (human) ]

    Gene ID: 28232, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLCO3A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 3A1provided by HGNC
    Primary source
    HGNC:HGNC:10952
    See related
    Ensembl:ENSG00000176463 MIM:612435; AllianceGenome:HGNC:10952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATPD; OATP-D; OATP3A1; OATPRP3; OATP-RP3; SLC21A11
    Summary
    Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in basal plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 11.4), lung (RPKM 6.4) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLCO3A1 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (91853708..92172435)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (89615458..89934870)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (92396938..92715665)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370974 Neighboring gene uncharacterized LOC124903608 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:92396360-92396534 Neighboring gene Sharpr-MPRA regulatory region 9082 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:92424907-92425482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:92493309-92494181 Neighboring gene uncharacterized LOC124903557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:92517318-92517818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:92517819-92518319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:92555079-92555579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10111 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:92634162-92634898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:92660697-92661288 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:92661469-92662168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:92662868-92663566 Neighboring gene Sharpr-MPRA regulatory region 9655 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:92667565-92668555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:92690101-92691004 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:92707869-92708626 Neighboring gene Sharpr-MPRA regulatory region 10912 Neighboring gene uncharacterized LOC107987227 Neighboring gene double homeobox A pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    EBI GWAS Catalog
    GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
    EBI GWAS Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40478

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 3A1
    Names
    PGE1 transporter
    organic anion transporter polypeptide-related protein 3
    organic anion-transporting polypeptide D
    sodium-independent organic anion transporter D
    solute carrier family 21 (organic anion transporter), member 11
    solute carrier family 21 member 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145044.1NP_001138516.1  solute carrier organic anion transporter family member 3A1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and contains an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC104020, AC113190, AC116903, AF205074, BC000585
      Consensus CDS
      CCDS45354.1
      UniProtKB/Swiss-Prot
      Q9UIG8
      Related
      ENSP00000387846.2, ENST00000424469.2
      Conserved Domains (3) summary
      cd06174
      Location:47286
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:467511
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:41619
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_013272.4NP_037404.2  solute carrier organic anion transporter family member 3A1 isoform 1

      See identical proteins and their annotated locations for NP_037404.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC104020, AC113190, AC116903, AF205074
      Consensus CDS
      CCDS10371.1
      UniProtKB/Swiss-Prot
      A8K4A7, B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2, Q9UIG8
      Related
      ENSP00000320634.6, ENST00000318445.11
      Conserved Domains (3) summary
      cd06174
      Location:47286
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:467511
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:41619
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RNA

    1. NR_135775.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104236, AC113190, AK310306, DB508493, HY004505
      Related
      ENST00000555769.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      91853708..92172435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      89615458..89934870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)