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    SULT1A1 sulfotransferase family 1A member 1 [ Homo sapiens (human) ]

    Gene ID: 6817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SULT1A1provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 1provided by HGNC
    Primary source
    HGNC:HGNC:11453
    See related
    Ensembl:ENSG00000196502 MIM:171150; AllianceGenome:HGNC:11453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; ts-PST; P-PST 1; HAST1/HAST2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 44.2), liver (RPKM 36.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SULT1A1 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28605258..28623375, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28772308..28790437)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28616579..28634696, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7310 Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28626587-28627161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7312 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Maternal genetic polymorphisms of phase II metabolic enzymes and the risk of fetal neural tube defects. Wang L, et al. Birth Defects Res A Clin Mol Teratol, 2014 Jan. PMID 24307569
    2. SULT1A1 Arg213His polymorphism and susceptibility of environment-related cancers: a meta analysis of 5,915 cases and 7,900 controls. Li K, et al. Mol Biol Rep, 2012 Mar. PMID 21670965
    3. Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis. Zhang C, et al. PLoS One, 2011. PMID 21695180, Free PMC Article
    4. SULT1A1 Arg213His polymorphism, smoked meat, and breast cancer risk: a case-control study and meta-analysis. Lee H, et al. DNA Cell Biol, 2012 May. PMID 22011087
    5. SULT1A1 Arg213His polymorphism and lung cancer risk: a meta-analysis. Liao SG, et al. Asian Pac J Cancer Prev, 2012. PMID 22524828

    See all (250) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
      Title: Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
    2. Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations.
      Title: Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations.
    3. Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
      Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
    4. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.
      Title: Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.
    5. Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1.
      Title: Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1.
    6. Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1).
      Title: Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1).
    7. These findings highlight the key insights of structural consequences caused by R213H mutation, which would enrich the understanding regarding the role of SULT1A1 mutation in cancer development.
      Title: Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.
    8. Different ethnic and racial populations have varying degrees of SULT1A1-mediated sulfation activity.
      Title: Multi-ethnic SULT1A1 copy number profiling with multiplex ligation-dependent probe amplification.
    9. Patients were categorized in three groups depending on the decreased SULT1A1 activity due to rs6839 and rs1042157: low activity group (rs6839 (GG) and rs1042157 (TT)); high activity group (rs6839 (AA) and rs1042157 (CC)); and medium activity group (all the other combinations of rs6839 and rs1042157). Associations between SULT1A1 phenotypes and clinical outcome (RFS) were explored
      Title: Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.
    10. Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts.
      Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
    Submit: New GeneRIF Correction See all GeneRIFs (125)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5163, MGC131921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amine metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1A1
    Names
    aryl sulfotransferase 1
    phenol-sulfating phenol sulfotransferase 1
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
    thermostable phenol sulfotransferase1
    NP_001046.2
    NP_001381350.1
    NP_001381351.1
    NP_001381352.1
    NP_001381353.1
    NP_001381354.1
    NP_803565.1
    NP_803566.1
    NP_803878.1
    NP_803880.2
    XP_016879093.1
    XP_016879094.1
    XP_016879097.1
    XP_016879099.1
    XP_047290500.1
    XP_047290501.1
    XP_047290502.1
    XP_047290503.1
    XP_047290504.1
    XP_047290505.1
    XP_047290506.1
    XP_054169761.1
    XP_054169762.1
    XP_054169763.1
    XP_054169764.1
    XP_054169765.1
    XP_054169766.1
    XP_054169767.1
    XP_054169768.1
    XP_054169769.1
    XP_054169770.1
    XP_054169771.1
    XP_054169772.1
    XP_054169773.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028128.1 RefSeqGene

      Range
      18502..23288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001055.4 → NP_001046.2  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_001046.2

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000321988.7, ENST00000314752.12
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001394421.1 → NP_001381350.1  sulfotransferase 1A1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_001394422.1 → NP_001381351.1  sulfotransferase 1A1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    4. NM_001394423.1 → NP_001381352.1  sulfotransferase 1A1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    5. NM_001394424.1 → NP_001381353.1  sulfotransferase 1A1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    6. NM_001394425.1 → NP_001381354.1  sulfotransferase 1A1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    7. NM_177529.3 → NP_803565.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803565.1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000456459.1, ENST00000566189.5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    8. NM_177530.4 → NP_803566.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803566.1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    9. NM_177534.4 → NP_803878.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803878.1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000457912.1, ENST00000569554.5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    10. NM_177536.5 → NP_803880.2  sulfotransferase 1A1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Conserved Domains (1) summary
      cl21551
      Location:24 → 188
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28605258..28623375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434549.1 → XP_047290505.1  sulfotransferase 1A1 isoform X3

    2. XM_047434547.1 → XP_047290503.1  sulfotransferase 1A1 isoform X1

    3. XM_047434544.1 → XP_047290500.1  sulfotransferase 1A1 isoform X1

    4. XM_017023608.2 → XP_016879097.1  sulfotransferase 1A1 isoform X1

      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 293
      Sulfotransfer_1; Sulfotransferase domain

    5. XM_047434546.1 → XP_047290502.1  sulfotransferase 1A1 isoform X1

    6. XM_047434545.1 → XP_047290501.1  sulfotransferase 1A1 isoform X1

    7. XM_047434548.1 → XP_047290504.1  sulfotransferase 1A1 isoform X2

      UniProtKB/Swiss-Prot
      P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7

    8. XM_017023610.2 → XP_016879099.1  sulfotransferase 1A1 isoform X1

      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 293
      Sulfotransfer_1; Sulfotransferase domain

    9. XM_017023605.2 → XP_016879094.1  sulfotransferase 1A1 isoform X1

      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 293
      Sulfotransfer_1; Sulfotransferase domain

    10. XM_017023604.2 → XP_016879093.1  sulfotransferase 1A1 isoform X1

      UniProtKB/TrEMBL
      H3BRY5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 293
      Sulfotransfer_1; Sulfotransferase domain

    11. XM_047434550.1 → XP_047290506.1  sulfotransferase 1A1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28772308..28790437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313786.1 → XP_054169761.1  sulfotransferase 1A1 isoform X5

    2. XM_054313788.1 → XP_054169763.1  sulfotransferase 1A1 isoform X7

    3. XM_054313787.1 → XP_054169762.1  sulfotransferase 1A1 isoform X6

    4. XM_054313789.1 → XP_054169764.1  sulfotransferase 1A1 isoform X8

    5. XM_054313791.1 → XP_054169766.1  sulfotransferase 1A1 isoform X10

    6. XM_054313792.1 → XP_054169767.1  sulfotransferase 1A1 isoform X11

    7. XM_054313794.1 → XP_054169769.1  sulfotransferase 1A1 isoform X1

    8. XM_054313797.1 → XP_054169772.1  sulfotransferase 1A1 isoform X3

    9. XM_054313790.1 → XP_054169765.1  sulfotransferase 1A1 isoform X9

    10. XM_054313798.1 → XP_054169773.1  sulfotransferase 1A1 isoform X1

    11. XM_054313793.1 → XP_054169768.1  sulfotransferase 1A1 isoform X2

    12. XM_054313796.1 → XP_054169771.1  sulfotransferase 1A1 isoform X1

    13. XM_054313795.1 → XP_054169770.1  sulfotransferase 1A1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50225.3 GenPept UniProtKB/Swiss-Prot:P50225

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