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    VMO1 vitelline membrane outer layer 1 homolog [ Homo sapiens (human) ]

    Gene ID: 284013, updated on 27-Nov-2024

    Summary

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    Official Symbol
    VMO1provided by HGNC
    Official Full Name
    vitelline membrane outer layer 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:30387
    See related
    Ensembl:ENSG00000182853 AllianceGenome:HGNC:30387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERGA6350; PRO21055
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 5.3), lung (RPKM 3.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See VMO1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4785285..4786364, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4674933..4676011, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4688580..4689659, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4642642-4643546 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4667359-4667521 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11548 Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4699218-4699816 Neighboring gene proteasome 20S subunit beta 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma. Wang L, et al. Cell Signal, 2024 Oct. PMID 39053673
    2. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. Shamsi FA, et al. Invest Ophthalmol Vis Sci, 2011 Nov 25. PMID 22025569
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
      Title: Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125880, MGC125881

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vitelline membrane outer layer protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144939.2 → NP_001138411.1  vitelline membrane outer layer protein 1 homolog isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BI836994, CD367473
      Consensus CDS
      CCDS45587.1
      UniProtKB/Swiss-Prot
      Q7Z5L0
      Related
      ENSP00000408166.2, ENST00000441199.2
      Conserved Domains (1) summary
      cd00220
      Location:35 → 106
      VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

    2. NM_001144940.2 → NP_001138412.1  vitelline membrane outer layer protein 1 homolog isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at the 3' end of exon 2, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC104195, BI836994, CD367284
      Consensus CDS
      CCDS45586.1
      UniProtKB/Swiss-Prot
      Q7Z5L0
      Related
      ENSP00000390450.2, ENST00000416307.6
      Conserved Domains (1) summary
      cd00220
      Location:35 → 91
      VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

    3. NM_001144941.2 → NP_001138413.1  vitelline membrane outer layer protein 1 homolog isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 4) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BI836994, CD367473
      Consensus CDS
      CCDS45585.1
      UniProtKB/Swiss-Prot
      Q7Z5L0
      Related
      ENSP00000346133.4, ENST00000354194.4
      Conserved Domains (1) summary
      cd00220
      Location:35 → 65
      VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...

    4. NM_182566.3 → NP_872372.1  vitelline membrane outer layer protein 1 homolog isoform 1 precursor

      See identical proteins and their annotated locations for NP_872372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC104195, CD367284
      Consensus CDS
      CCDS11055.1
      UniProtKB/Swiss-Prot
      C9JQ15, E9PAU9, E9PGP4, Q3SXP1, Q7Z5L0, Q8IUY1
      Related
      ENSP00000328397.5, ENST00000328739.6
      Conserved Domains (1) summary
      pfam03762
      Location:36 → 200
      VOMI; Vitelline membrane outer layer protein I (VOMI)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4785285..4786364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4674933..4676011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z5L0.1 GenPept UniProtKB/Swiss-Prot:Q7Z5L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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