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    TRMT11 tRNA methyltransferase 11 homolog [ Homo sapiens (human) ]

    Gene ID: 60487, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TRMT11provided by HGNC
    Official Full Name
    tRNA methyltransferase 11 homologprovided by HGNC
    Primary source
    HGNC:HGNC:21080
    See related
    Ensembl:ENSG00000066651 AllianceGenome:HGNC:21080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRM11; MDS024; C6orf75; TRMT11-1
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation and tRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRMT11 in Genome Data Viewer
    Location:
    6q22.32
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (125986540..126272343)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (127175155..127468301)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126307686..126400874)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene uncharacterized LOC124901397 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:126239365-126240564 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126306909-126307739 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126307740-126308569 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene Sharpr-MPRA regulatory region 12057 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25036 Neighboring gene centromere protein W Neighboring gene microRNA 588

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Germline predictors of androgen deprivation therapy response in advanced prostate cancer. Kohli M, et al. Mayo Clin Proc, 2012 Mar. PMID 22386179, Free PMC Article
    2. Activation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112. Bourgeois G, et al. Nucleic Acids Res, 2017 Feb 28. PMID 27986851, Free PMC Article
    3. Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor. Brūmele B, et al. Int J Mol Sci, 2021 Dec 18. PMID 34948388, Free PMC Article
    4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Elks CE, et al. Nat Genet, 2010 Dec. PMID 21102462, Free PMC Article
    5. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNPs associated with androgen deprivation failure in advanced prostate cancer
      Title: Germline predictors of androgen deprivation therapy response in advanced prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Names
    tRNA guanosine-2'-O-methyltransferase TRM11 homolog
    NP_001026882.2
    NP_001337509.1
    NP_001337510.1
    NP_001337511.1
    NP_001337512.1
    NP_001337513.1
    NP_001337514.1
    NP_001337515.1
    NP_001337516.1
    NP_001337517.1
    NP_001337518.1
    NP_001337519.1
    NP_001337520.1
    NP_001337521.1
    NP_001337522.1
    NP_001337523.1
    NP_001337524.1
    NP_001337525.1
    NP_001337526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031712.3 → NP_001026882.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform a

      See identical proteins and their annotated locations for NP_001026882.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF532977, BC056878
      Consensus CDS
      CCDS35496.1
      UniProtKB/Swiss-Prot
      E1P570, Q5JY11, Q6PGQ5, Q7Z4G4, Q9HC13
      Related
      ENSP00000333934.5, ENST00000334379.11
      Conserved Domains (2) summary
      COG1041
      Location:9 → 416
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190 → 321
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001350580.2 → NP_001337509.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:9 → 404
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    3. NM_001350581.2 → NP_001337510.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    4. NM_001350582.2 → NP_001337511.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    5. NM_001350583.2 → NP_001337512.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    6. NM_001350584.2 → NP_001337513.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3-5, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    7. NM_001350585.2 → NP_001337514.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform d

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      COG1041
      Location:1 → 218
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    8. NM_001350586.2 → NP_001337515.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    9. NM_001350587.2 → NP_001337516.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 8 and 10-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    10. NM_001350588.2 → NP_001337517.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 8, 9, and 11-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    11. NM_001350589.2 → NP_001337518.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 8-10 and 12-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    12. NM_001350590.2 → NP_001337519.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 8-11 and 13-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    13. NM_001350591.2 → NP_001337520.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 8-12 and 14-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    14. NM_001350592.2 → NP_001337521.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 8-13 and 15-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    15. NM_001350593.2 → NP_001337522.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 8-14 and 16-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    16. NM_001350594.2 → NP_001337523.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 8-15 and 17-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    17. NM_001350595.2 → NP_001337524.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 8-16, 18, and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    18. NM_001350596.2 → NP_001337525.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 8-17 and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    19. NM_001350597.2 → NP_001337526.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 8-18, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_146795.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Related
      ENST00000479748.5

    2. NR_146796.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689

    3. NR_146797.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    4. NR_146798.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689

    5. NR_146799.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    6. NR_146800.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689

    7. NR_146801.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689

    8. NR_146802.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689

    9. NR_146803.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    10. NR_146804.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      125986540..126272343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007059327.1 RNA Sequence

    2. XR_007059304.1 RNA Sequence

    3. XR_007059310.1 RNA Sequence

    4. XR_007059309.1 RNA Sequence

    5. XR_007059298.1 RNA Sequence

    6. XR_007059293.1 RNA Sequence

    7. XR_007059296.1 RNA Sequence

    8. XR_007059311.1 RNA Sequence

    9. XR_007059324.1 RNA Sequence

    10. XR_007059325.1 RNA Sequence

    11. XR_007059326.1 RNA Sequence

    12. XR_007059301.1 RNA Sequence

    13. XR_007059299.1 RNA Sequence

    14. XR_007059297.1 RNA Sequence

    15. XR_007059290.1 RNA Sequence

    16. XR_007059302.1 RNA Sequence

    17. XR_007059314.1 RNA Sequence

    18. XR_007059289.1 RNA Sequence

    19. XR_007059303.1 RNA Sequence

    20. XR_007059307.1 RNA Sequence

    21. XR_007059312.1 RNA Sequence

    22. XR_007059291.1 RNA Sequence

    23. XR_007059306.1 RNA Sequence

    24. XR_007059295.1 RNA Sequence

    25. XR_007059313.1 RNA Sequence

    26. XR_007059322.1 RNA Sequence

    27. XR_007059323.1 RNA Sequence

    28. XR_007059316.1 RNA Sequence

    29. XR_007059317.1 RNA Sequence

    30. XR_007059320.1 RNA Sequence

    31. XR_007059305.1 RNA Sequence

    32. XR_007059321.1 RNA Sequence

    33. XR_007059300.1 RNA Sequence

    34. XR_007059294.1 RNA Sequence

    35. XR_007059315.1 RNA Sequence

    36. XR_007059292.1 RNA Sequence

    37. XR_007059318.1 RNA Sequence

    38. XR_007059319.1 RNA Sequence

    39. XR_007059308.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      127175155..127468301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487421.1 RNA Sequence

    2. XR_008487389.1 RNA Sequence

    3. XR_008487395.1 RNA Sequence

    4. XR_008487394.1 RNA Sequence

    5. XR_008487383.1 RNA Sequence

    6. XR_008487379.1 RNA Sequence

    7. XR_008487382.1 RNA Sequence

    8. XR_008487396.1 RNA Sequence

    9. XR_008487419.1 RNA Sequence

    10. XR_008487420.1 RNA Sequence

    11. XR_008487386.1 RNA Sequence

    12. XR_008487384.1 RNA Sequence

    13. XR_008487376.1 RNA Sequence

    14. XR_008487387.1 RNA Sequence

    15. XR_008487375.1 RNA Sequence

    16. XR_008487388.1 RNA Sequence

    17. XR_008487392.1 RNA Sequence

    18. XR_008487397.1 RNA Sequence

    19. XR_008487377.1 RNA Sequence

    20. XR_008487391.1 RNA Sequence

    21. XR_008487381.1 RNA Sequence

    22. XR_008487398.1 RNA Sequence

    23. XR_008487417.1 RNA Sequence

    24. XR_008487400.1 RNA Sequence

    25. XR_008487401.1 RNA Sequence

    26. XR_008487399.1 RNA Sequence

    27. XR_008487403.1 RNA Sequence

    28. XR_008487405.1 RNA Sequence

    29. XR_008487402.1 RNA Sequence

    30. XR_008487404.1 RNA Sequence

    31. XR_008487406.1 RNA Sequence

    32. XR_008487407.1 RNA Sequence

    33. XR_008487413.1 RNA Sequence

    34. XR_008487416.1 RNA Sequence

    35. XR_008487418.1 RNA Sequence

    36. XR_008487410.1 RNA Sequence

    37. XR_008487414.1 RNA Sequence

    38. XR_008487390.1 RNA Sequence

    39. XR_008487415.1 RNA Sequence

    40. XR_008487385.1 RNA Sequence

    41. XR_008487380.1 RNA Sequence

    42. XR_008487409.1 RNA Sequence

    43. XR_008487378.1 RNA Sequence

    44. XR_008487411.1 RNA Sequence

    45. XR_008487412.1 RNA Sequence

    46. XR_008487393.1 RNA Sequence

    47. XR_008487408.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021820.1: Suppressed sequence

      Description
      NM_021820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate; both the transcript and the protein have no support.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z4G4.1 GenPept UniProtKB/Swiss-Prot:Q7Z4G4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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