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    FABP7 fatty acid binding protein 7 [ Homo sapiens (human) ]

    Gene ID: 2173, updated on 26-Nov-2024

    Summary

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    Official Symbol
    FABP7provided by HGNC
    Official Full Name
    fatty acid binding protein 7provided by HGNC
    Primary source
    HGNC:HGNC:3562
    See related
    Ensembl:ENSG00000164434 MIM:602965; AllianceGenome:HGNC:3562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRG; BLBP; FABPB; B-FABP
    Summary
    The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in brain (RPKM 8.9) and skin (RPKM 0.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See FABP7 in Genome Data Viewer
    Location:
    6q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (122749201..122784074)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (123937487..123972367)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (123070346..123105219)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cAMP-dependent protein kinase inhibitor beta Neighboring gene uncharacterized LOC124901391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884400-122884937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884938-122885474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:122932197-122932842 Neighboring gene MPRA-validated peak6076 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:123017072-123018271 Neighboring gene MPRA-validated peak6077 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:123076853-123077432 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:123110213-123110714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:123110715-123111214 Neighboring gene Sharpr-MPRA regulatory region 4155 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89596 Neighboring gene Sharpr-MPRA regulatory region 10347 Neighboring gene sphingomyelin phosphodiesterase acid like 3A Neighboring gene MPRA-validated peak6080 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:123141927-123142470 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:123142471-123143014 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:123165703-123166295 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:123166296-123166889 Neighboring gene ATP synthase membrane subunit g pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of fatty acid binding protein 7 and its effect on fatty acid of renal cell carcinoma cell lines. Takaoka N, et al. BMC Cancer, 2017 Mar 14. PMID 28292269, Free PMC Article
    2. FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status. Kaloshi G, et al. J Neurooncol, 2007 Sep. PMID 17415524
    3. [Transcriptome analyses in renal cell carcinoma. Combination of laser microdissection and microarrays]. Buchner A, et al. Urologe A, 2007 Sep. PMID 17646957
    4. B-FABP-expressing radial glial cells: the malignant glioma cell of origin? Mita R, et al. Neoplasia, 2007 Sep. PMID 17898869, Free PMC Article
    5. Role of FABP7 in tumor cell signaling. Kagawa Y, et al. Adv Biol Regul, 2019 Jan. PMID 30245263

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.
      Title: FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.
    2. Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRalpha neurogenic pathway.
      Title: Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway.
    3. The HOPX and BLBP landscape and gliogenic regions in developing human brain.
      Title: The HOPX and BLBP landscape and gliogenic regions in developing human brain.
    4. Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.
      Title: Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.
    5. Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting beta-Catenin Degradation.
      Title: Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation.
    6. Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.
      Title: Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.
    7. Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.
      Title: Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.
    8. Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
      Title: Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
    9. Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.
      Title: Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.
    10. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.
      Title: FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid-binding protein, brain
    Names
    brain lipid-binding protein
    brain-type fatty acid-binding protein
    hypothetical protein DKFZp547J2313
    mammary-derived growth inhibitor-related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050619.1 RefSeqGene

      Range
      35516..39874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001319039.2 → NP_001305968.1  fatty acid-binding protein, brain isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AL512688, AL645811, BI860090
      Consensus CDS
      CCDS83121.1
      UniProtKB/Swiss-Prot
      O15540
      Related
      ENSP00000348931.4, ENST00000356535.4
      Conserved Domains (1) summary
      pfam00061
      Location:8 → 117
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001319041.2 → NP_001305970.1  fatty acid-binding protein, brain isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) retains two alternate segments compared to variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB208815, AL645811, BI860090, BU736791, BX461253
      UniProtKB/TrEMBL
      Q59HE4
      Conserved Domains (1) summary
      cl10502
      Location:2 → 82
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. NM_001319042.2 → NP_001305971.1  fatty acid-binding protein, brain isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. The 5' end of this transcript contains long terminal repeat (LTR) sequence and initiates from an LTR promoter. (PMID: 25114248)
      Source sequence(s)
      AW156936, KM111186
      UniProtKB/TrEMBL
      A0A077H155
      Conserved Domains (1) summary
      pfam00061
      Location:21 → 128
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    4. NM_001446.5 → NP_001437.1  fatty acid-binding protein, brain isoform 1

      See identical proteins and their annotated locations for NP_001437.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AW156936, BC012299
      Consensus CDS
      CCDS5127.1
      UniProtKB/Swiss-Prot
      B2R4L1, O14951, O15540, Q6IAU7, Q9H047
      Related
      ENSP00000357429.3, ENST00000368444.8
      Conserved Domains (1) summary
      pfam00061
      Location:8 → 132
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      122749201..122784074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      123937487..123972367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15540.3 GenPept UniProtKB/Swiss-Prot:O15540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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