TAAR1 trace amine associated receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAAR1provided by HGNC
Official Full Name: trace amine associated receptor 1provided by HGNC
Primary source: HGNC:HGNC:17734
See related: Ensembl:ENSG00000146399 MIM:609333; AllianceGenome:HGNC:17734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TA1; TAR1; TRAR1
Summary: The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
Orthologs: mouse all
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Genomic context

Location:: 6q23.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (132643312..132659182, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (133838279..133854151, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (132964451..132980321, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular basis of human trace amine-associated receptor 1 activation.
Title: Molecular basis of human trace amine-associated receptor 1 activation.
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Title: Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
T1AM/TAAR1 System Reduces Inflammatory Response and beta-Amyloid Toxicity in Human Microglial HMC3 Cell Line.
Title: T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line.
Thymosin alpha1 interacts with Galectin-1 modulating the beta-galactosides affinity and inducing alteration in the biological activity.
Title: Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity.
Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review.
Title: Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review.
Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
Title: Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation.
Title: TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation.
Cadaverine and Spermine Elicit Ca(2+) Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway.
Title: Cadaverine and Spermine Elicit Ca(2+) Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway.
Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.
Title: Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection upregulates TAAR1 in lymph nodes of infected patients	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483092

PMC55357P1 (e-PCR)
- UniSTS:273333

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: trace amine-associated receptor 1

Names: trace amine receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.