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    BCOR BCL6 corepressor [ Homo sapiens (human) ]

    Gene ID: 54880, updated on 12-Nov-2024

    Summary

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    Official Symbol
    BCORprovided by HGNC
    Official Full Name
    BCL6 corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:20893
    See related
    Ensembl:ENSG00000183337 MIM:300485; AllianceGenome:HGNC:20893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAA2; ANOP2; MCOPS2
    Summary
    The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.0), lymph node (RPKM 7.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BCOR in Genome Data Viewer
    Location:
    Xp11.4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (40051246..40177329, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (39452491..39578567, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (39910499..40036582, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39788469-39788968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39787967-39788468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39808059-39808558 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:39813184-39813412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39828711-39829255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39832750-39833500 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:39863451-39863973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:39865487-39866423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39867643-39868270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39871294-39872017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20740 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:39873755-39874254 Neighboring gene long intergenic non-protein coding RNA 3053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39918103-39918602 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:39932994-39934193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20741 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:39950161-39950788 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:39952045-39952671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39959601-39960121 Neighboring gene translation initiation factor IF-2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39961792-39962382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39966379-39967135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20753 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:39971030-39971309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:39999891-40000415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:40007775-40008318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20754 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:40015867-40016606 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40016607-40017346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20756 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:40028374-40029064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:40029065-40029755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20761 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:40041386-40041565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20762 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40070301-40070852 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:40097124-40097650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29539 Neighboring gene Sharpr-MPRA regulatory region 4836 Neighboring gene long intergenic non-protein coding RNA 3099 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29540 Neighboring gene uncharacterized LOC105373182 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas. Kao YC, et al. Am J Surg Pathol, 2018 May. PMID 29300189, Free PMC Article
    2. Meta-analysis of BCOR rearranged sarcomas: challenging the therapeutic approach. Kyriazoglou A, et al. Acta Oncol, 2021 Jun. PMID 33630701
    3. Soft Tissue and Visceral Organ Sarcomas With BCOR Alterations. Whittle SB, et al. J Pediatr Hematol Oncol, 2022 Jul 1. PMID 35537005, Free PMC Article
    4. Preoperative diagnosis of clear cell sarcoma of the kidney by detection of BCOR internal tandem duplication in circulating tumor DNA. Ueno-Yokohata H, et al. Genes Chromosomes Cancer, 2018 Oct. PMID 30126017
    5. BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology. Chiang S, et al. Mod Pathol, 2017 Sep. PMID 28621321, Free PMC Article

    See all (190) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dental abnormalities observed in the oculo-facio-cardio-dental (OFCD) syndrome present in two Czech families bearing novel de novo BCOR pathogenic variants.
      Title: Dental abnormalities observed in the oculo-facio-cardio-dental (OFCD) syndrome present in two Czech families bearing novel de novo BCOR pathogenic variants.
    2. The Combined Immunohistochemical Expression of GLI1 and BCOR in Synovial Sarcomas for the Identification of Three Risk Groups and Their Prognostic Outcomes: A Study of 52 Patients.
      Title: The Combined Immunohistochemical Expression of GLI1 and BCOR in Synovial Sarcomas for the Identification of Three Risk Groups and Their Prognostic Outcomes: A Study of 52 Patients.
    3. A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.
      Title: A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.
    4. BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion.
      Title: BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion.
    5. Evaluation of Lineage/Site-specific Nuclear Immunohistochemical Markers SATB2, Cyclin D1, SALL4, and BCOR in High-grade Endometrial Carcinomas.
      Title: Evaluation of Lineage/Site-specific Nuclear Immunohistochemical Markers SATB2, Cyclin D1, SALL4, and BCOR in High-grade Endometrial Carcinomas.
    6. Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney.
      Title: Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney.
    7. A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
      Title: A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
    8. Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles.
      Title: Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles.
    9. X-linked BCOR variants identified in Chinese Han patients with congenital heart disease.
      Title: X-linked BCOR variants identified in Chinese Han patients with congenital heart disease.
    10. BCOR variants are associated with X-linked recessive partial epilepsy.
      Title: BCOR variants are associated with X-linked recessive partial epilepsy.
    Submit: New GeneRIF Correction See all GeneRIFs (100)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microphthalmia, syndromic 1
    MedGen: C0796016 OMIM: 309800 GeneReviews: Not available
    		Compare labs
    Oculofaciocardiodental syndrome
    MedGen: C1846265 OMIM: 300166 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2012-10-04)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2012-10-04)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20285, FLJ38041, KIAA1575, MGC71031, MGC131961

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blastocyst hatching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of tooth mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of axis polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BCOR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BCL-6 corepressor
    Names
    BCL-6 coreceptor
    BCL-6 interacting corepressor
    BCL6 interacting corepressor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008880.1 RefSeqGene

      Range
      5001..131084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_627

    mRNA and Protein(s)

    1. NM_001123383.1 → NP_001116855.1  BCL-6 corepressor isoform a

      See identical proteins and their annotated locations for NP_001116855.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 5. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC092198, AK056538, BC114220
      Consensus CDS
      CCDS14250.1
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000345923.4, ENST00000342274.8
      Conserved Domains (5) summary
      cd00204
      Location:1423 → 1531
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1598 → 1712
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1433 → 1524
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1168 → 1380
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1429 → 1460
      ANK; ANK repeat [structural motif]

    2. NM_001123384.2 → NP_001116856.1  BCL-6 corepressor isoform b

      See identical proteins and their annotated locations for NP_001116856.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate in-frame segments compared to variant 5. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AC092198, BC114220
      Consensus CDS
      CCDS48092.1
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000367716.4, ENST00000378455.8
      Conserved Domains (5) summary
      cd00204
      Location:1405 → 1513
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1580 → 1694
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1415 → 1506
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1150 → 1362
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1411 → 1442
      ANK; ANK repeat [structural motif]

    3. NM_001123385.2 → NP_001116857.1  BCL-6 corepressor isoform c

      See identical proteins and their annotated locations for NP_001116857.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC092198, AK056538, AL591802, AL698729, AY316592, BC114220
      Consensus CDS
      CCDS48093.1
      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000367705.4, ENST00000378444.9
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    4. NM_017745.6 → NP_060215.4  BCL-6 corepressor isoform a

      See identical proteins and their annotated locations for NP_060215.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 5. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC092198, AK056538, AL591802, AL698729, BC114220
      Consensus CDS
      CCDS14250.1
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000380512.3, ENST00000397354.7
      Conserved Domains (5) summary
      cd00204
      Location:1423 → 1531
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1598 → 1712
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1433 → 1524
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1168 → 1380
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1429 → 1460
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      40051246..40177329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442202.1 → XP_047298158.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    2. XM_005272616.2 → XP_005272673.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_005272673.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000499892.2, ENST00000672922.2
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    3. XM_047442223.1 → XP_047298179.1  BCL-6 corepressor isoform X4

    4. XM_047442205.1 → XP_047298161.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    5. XM_047442213.1 → XP_047298169.1  BCL-6 corepressor isoform X3

    6. XM_011543931.3 → XP_011542233.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_011542233.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    7. XM_047442219.1 → XP_047298175.1  BCL-6 corepressor isoform X4

    8. XM_047442201.1 → XP_047298157.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    9. XM_047442210.1 → XP_047298166.1  BCL-6 corepressor isoform X3

    10. XM_011543930.2 → XP_011542232.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_011542232.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    11. XM_047442221.1 → XP_047298177.1  BCL-6 corepressor isoform X4

    12. XM_047442208.1 → XP_047298164.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    13. XM_047442211.1 → XP_047298167.1  BCL-6 corepressor isoform X3

    14. XM_011543929.3 → XP_011542231.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_011542231.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    15. XM_047442228.1 → XP_047298184.1  BCL-6 corepressor isoform X4

    16. XM_047442197.1 → XP_047298153.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      Related
      ENSP00000483217.2, ENST00000615339.2

    17. XM_047442214.1 → XP_047298170.1  BCL-6 corepressor isoform X3

    18. XM_047442216.1 → XP_047298172.1  BCL-6 corepressor isoform X3

    19. XM_047442207.1 → XP_047298163.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    20. XM_047442224.1 → XP_047298180.1  BCL-6 corepressor isoform X4

    21. XM_047442204.1 → XP_047298160.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    22. XM_047442198.1 → XP_047298154.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    23. XM_047442199.1 → XP_047298155.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    24. XM_047442218.1 → XP_047298174.1  BCL-6 corepressor isoform X3

    25. XM_047442227.1 → XP_047298183.1  BCL-6 corepressor isoform X4

    26. XM_047442196.1 → XP_047298152.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      Related
      ENSP00000505507.1, ENST00000680831.1

    27. XM_047442222.1 → XP_047298178.1  BCL-6 corepressor isoform X4

    28. XM_047442209.1 → XP_047298165.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    29. XM_047442217.1 → XP_047298173.1  BCL-6 corepressor isoform X3

    30. XM_047442220.1 → XP_047298176.1  BCL-6 corepressor isoform X4

    31. XM_047442203.1 → XP_047298159.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231
      Related
      ENSP00000403823.3, ENST00000427012.3

    32. XM_047442212.1 → XP_047298168.1  BCL-6 corepressor isoform X3

      Related
      ENSP00000408006.2, ENST00000413905.6

    33. XM_005272618.4 → XP_005272675.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_005272675.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000384485.3, ENST00000406200.4
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    34. XM_005272620.5 → XP_005272677.1  BCL-6 corepressor isoform X4

      See identical proteins and their annotated locations for XP_005272677.1

      UniProtKB/TrEMBL
      H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1405 → 1513
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1580 → 1694
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1415 → 1506
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1150 → 1362
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1411 → 1442
      ANK; ANK repeat [structural motif]

    35. XM_005272619.5 → XP_005272676.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231, H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1439 → 1547
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1614 → 1728
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1449 → 1540
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1184 → 1396
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1445 → 1476
      ANK; ANK repeat [structural motif]

    36. XM_017029616.3 → XP_016885105.1  BCL-6 corepressor isoform X5

      UniProtKB/TrEMBL
      H7BZ37, H7C2V9
      Related
      ENSP00000387552.2, ENST00000442018.6

    37. XM_017029615.2 → XP_016885104.1  BCL-6 corepressor isoform X3

      UniProtKB/TrEMBL
      H7C2V9
      Related
      ENSP00000500446.1, ENST00000673391.1
      Conserved Domains (5) summary
      cd00204
      Location:1423 → 1531
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1598 → 1712
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1433 → 1524
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1168 → 1380
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1429 → 1460
      ANK; ANK repeat [structural motif]

    38. XM_006724536.4 → XP_006724599.1  BCL-6 corepressor isoform X1

      See identical proteins and their annotated locations for XP_006724599.1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      UniProtKB/TrEMBL
      H7C2V9
      Conserved Domains (5) summary
      cd00204
      Location:1457 → 1565
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1632 → 1746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1467 → 1558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1202 → 1414
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1463 → 1494
      ANK; ANK repeat [structural motif]

    39. XM_047442225.1 → XP_047298181.1  BCL-6 corepressor isoform X4

    40. XM_047442206.1 → XP_047298162.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    41. XM_047442226.1 → XP_047298182.1  BCL-6 corepressor isoform X4

    42. XM_047442215.1 → XP_047298171.1  BCL-6 corepressor isoform X3

    43. XM_047442200.1 → XP_047298156.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
      Related
      ENSP00000505761.1, ENST00000679513.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      39452491..39578567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327306.1 → XP_054183281.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    2. XM_054327293.1 → XP_054183268.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    3. XM_054327314.1 → XP_054183289.1  BCL-6 corepressor isoform X3

    4. XM_054327295.1 → XP_054183270.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    5. XM_054327309.1 → XP_054183284.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    6. XM_054327326.1 → XP_054183301.1  BCL-6 corepressor isoform X4

    7. XM_054327331.1 → XP_054183306.1  BCL-6 corepressor isoform X4

    8. XM_054327321.1 → XP_054183296.1  BCL-6 corepressor isoform X3

    9. XM_054327301.1 → XP_054183276.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    10. XM_054327320.1 → XP_054183295.1  BCL-6 corepressor isoform X3

    11. XM_054327333.1 → XP_054183308.1  BCL-6 corepressor isoform X4

    12. XM_054327312.1 → XP_054183287.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    13. XM_054327294.1 → XP_054183269.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    14. XM_054327305.1 → XP_054183280.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    15. XM_054327334.1 → XP_054183309.1  BCL-6 corepressor isoform X4

    16. XM_054327297.1 → XP_054183272.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    17. XM_054327315.1 → XP_054183290.1  BCL-6 corepressor isoform X3

    18. XM_054327317.1 → XP_054183292.1  BCL-6 corepressor isoform X3

    19. XM_054327311.1 → XP_054183286.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    20. XM_054327327.1 → XP_054183302.1  BCL-6 corepressor isoform X4

    21. XM_054327308.1 → XP_054183283.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    22. XM_054327299.1 → XP_054183274.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    23. XM_054327300.1 → XP_054183275.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    24. XM_054327319.1 → XP_054183294.1  BCL-6 corepressor isoform X3

    25. XM_054327330.1 → XP_054183305.1  BCL-6 corepressor isoform X4

    26. XM_054327296.1 → XP_054183271.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    27. XM_054327325.1 → XP_054183300.1  BCL-6 corepressor isoform X4

    28. XM_054327313.1 → XP_054183288.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    29. XM_054327318.1 → XP_054183293.1  BCL-6 corepressor isoform X3

    30. XM_054327322.1 → XP_054183297.1  BCL-6 corepressor isoform X3

    31. XM_054327332.1 → XP_054183307.1  BCL-6 corepressor isoform X4

    32. XM_054327303.1 → XP_054183278.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    33. XM_054327307.1 → XP_054183282.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    34. XM_054327324.1 → XP_054183299.1  BCL-6 corepressor isoform X4

    35. XM_054327304.1 → XP_054183279.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    36. XM_054327335.1 → XP_054183310.1  BCL-6 corepressor isoform X5

      UniProtKB/TrEMBL
      H7BZ37

    37. XM_054327323.1 → XP_054183298.1  BCL-6 corepressor isoform X3

    38. XM_054327298.1 → XP_054183273.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    39. XM_054327328.1 → XP_054183303.1  BCL-6 corepressor isoform X4

    40. XM_054327310.1 → XP_054183285.1  BCL-6 corepressor isoform X2

      UniProtKB/TrEMBL
      H7C231

    41. XM_054327316.1 → XP_054183291.1  BCL-6 corepressor isoform X3

    42. XM_054327329.1 → XP_054183304.1  BCL-6 corepressor isoform X4

    43. XM_054327302.1 → XP_054183277.1  BCL-6 corepressor isoform X1

      UniProtKB/Swiss-Prot
      D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130139.1: Suppressed sequence

      Description
      NM_001130139.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    2. NM_020926.2: Suppressed sequence

      Description
      NM_020926.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6W2J9.1 GenPept UniProtKB/Swiss-Prot:Q6W2J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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