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    BRE4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851367, updated on 11-Sep-2024

    Summary

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    Official Symbol
    BRE4
    Primary source
    SGD:S000002390
    Locus tag
    YDL231C
    See related
    AllianceGenome:SGD:S000002390; FungiDB:YDL231C; VEuPathDB:YDL231C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endocytosis. Located in cell periphery. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (38867..42244, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mfg1p Neighboring gene olichyl-diphosphooligosaccharide--protein glycotransferase OST4 Neighboring gene tyrosine protein phosphatase PTP1 Neighboring gene Hsp70 family ATPase SSB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Wiederkehr A, et al. Yeast, 2001 Jun. PMID 11378903
    2. Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Murén E, et al. Yeast, 2001 Jan 30. PMID 11169758
    3. A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. de Groot PW, et al. Comp Funct Genomics, 2001. PMID 18628907, Free PMC Article
    4. Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Böhm S, et al. Nucleic Acids Res, 1997 Jun 15. PMID 9171100, Free PMC Article
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bre4p
    NP_010050.1
    • Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      38867..42244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180291.1 → NP_010050.1  TPA: Bre4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRC5, Q07660
      UniProtKB/TrEMBL
      B3LHA7, N1PA97
      Conserved Domains (2) summary
      pfam10337
      Location:148 → 279
      ArAE_2_N; Putative ER transporter, 6TM, N-terminal
      pfam13515
      Location:724 → 855
      FUSC_2; Fusaric acid resistance protein-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07660.1

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