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    CUS1 U2 snRNP complex subunit CUS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855281, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CUS1
    Gene description
    U2 snRNP complex subunit CUS1
    Primary source
    FungiDB:YMR240C
    Locus tag
    YMR240C
    See related
    SGD:S000004853; AllianceGenome:SGD:S000004853; VEuPathDB:YMR240C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in spliceosomal complex assembly. Part of U2 snRNP and U2-type prespliceosome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CUS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (749930..751240, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene ribonuclease III Neighboring gene Yhm2p Neighboring gene ribosomal 60S subunit protein L20A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. van Roon AM, et al. RNA, 2017 Jun. PMID 28348170, Free PMC Article
    2. Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits. Igel H, et al. RNA, 1998 Jan. PMID 9436903, Free PMC Article
    3. Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Pauling MH, et al. Mol Cell Biol, 2000 Mar. PMID 10688664, Free PMC Article
    4. CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Wells SE, et al. Genes Dev, 1996 Jan 15. PMID 8566755
    5. Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits. Yan D, et al. Mol Cell Biol, 1996 Mar. PMID 8622683, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit CUS1
    NP_013967.1
    • Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      749930..751240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182747.1 → NP_013967.1  TPA: U2 snRNP complex subunit CUS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W066, Q02554, Q04012
      UniProtKB/TrEMBL
      A0A8H4F9L8, A6ZMV3, B3LMC8, B5VQ09, C7GRB1, C8ZFA5, N1NZ28
      Conserved Domains (1) summary
      COG5182
      Location:1 → 436
      CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02554.1

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