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    C5orf24 chromosome 5 open reading frame 24 [ Homo sapiens (human) ]

    Gene ID: 134553, updated on 17-Sep-2024

    Summary

    Official Symbol
    C5orf24provided by HGNC
    Official Full Name
    chromosome 5 open reading frame 24provided by HGNC
    Primary source
    HGNC:HGNC:26746
    See related
    Ensembl:ENSG00000181904 AllianceGenome:HGNC:26746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in thyroid (RPKM 16.9), endometrium (RPKM 16.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C5orf24 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134833602..134859735)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (135360554..135386687)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134181370..134195425)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23162 Neighboring gene calcium modulating ligand Neighboring gene DEAD-box helicase 46 Neighboring gene ribosomal protein L34 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:134181369-134182104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134210028-134210733 Neighboring gene uncharacterized LOC124901071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23166 Neighboring gene thioredoxin domain containing 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:134240734-134241318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134241319-134241904 Neighboring gene Sharpr-MPRA regulatory region 11731 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 Neighboring gene MT-CYB pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135586.1NP_001129058.1  UPF0461 protein C5orf24 isoform 1

      See identical proteins and their annotated locations for NP_001129058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC006077, DA760705
      Consensus CDS
      CCDS4179.1
      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
      Related
      ENSP00000378427.3, ENST00000394976.4
      Conserved Domains (1) summary
      pfam17724
      Location:1188
      DUF5568; Family of unknown function (DUF5568)
    2. NM_001300894.2NP_001287823.1  UPF0461 protein C5orf24 isoform 2

      See identical proteins and their annotated locations for NP_001287823.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, which results in an alternate translation stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF085880, AJ437658, AV707506, BC053677, DA433671
      Consensus CDS
      CCDS75307.1
      UniProtKB/Swiss-Prot
      Q7Z6I8
      Related
      ENSP00000421647.1, ENST00000504727.1
      Conserved Domains (1) summary
      pfam17724
      Location:1143
      DUF5568; Family of unknown function (DUF5568)
    3. NM_152409.3NP_689622.2  UPF0461 protein C5orf24 isoform 1

      See identical proteins and their annotated locations for NP_689622.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC006077, BC053677
      Consensus CDS
      CCDS4179.1
      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
      Related
      ENSP00000337044.4, ENST00000338051.4
      Conserved Domains (1) summary
      pfam17724
      Location:1188
      DUF5568; Family of unknown function (DUF5568)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      134833602..134859735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009050.2XP_016864539.1  UPF0461 protein C5orf24 isoform X1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
      Conserved Domains (1) summary
      pfam17724
      Location:1188
      DUF5568; Family of unknown function (DUF5568)
    2. XM_005271889.4XP_005271946.1  UPF0461 protein C5orf24 isoform X1

      See identical proteins and their annotated locations for XP_005271946.1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
      Related
      ENSP00000395764.2, ENST00000435259.2
      Conserved Domains (1) summary
      pfam17724
      Location:1188
      DUF5568; Family of unknown function (DUF5568)
    3. XM_017009049.2XP_016864538.1  UPF0461 protein C5orf24 isoform X1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
      Conserved Domains (1) summary
      pfam17724
      Location:1188
      DUF5568; Family of unknown function (DUF5568)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      135360554..135386687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351653.1XP_054207628.1  UPF0461 protein C5orf24 isoform X1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
    2. XM_054351651.1XP_054207626.1  UPF0461 protein C5orf24 isoform X1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9
    3. XM_054351652.1XP_054207627.1  UPF0461 protein C5orf24 isoform X1

      UniProtKB/Swiss-Prot
      D3DQA7, Q7Z6I8, Q86Y53, Q8N1T9