ENDOD1 endonuclease domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ENDOD1provided by HGNC
Official Full Name: endonuclease domain containing 1provided by HGNC
Primary source: HGNC:HGNC:29129
See related: Ensembl:ENSG00000149218 MIM:619568; AllianceGenome:HGNC:29129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in innate immune response. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in prostate (RPKM 33.4), brain (RPKM 27.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (95089846..95132645)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (95096886..95139763)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (94823010..94865809)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of ENDOD1 suppressed cell proliferation, induced G0/G1 cell cycle arrest and inhibited cell migration and invasion.
Title: Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with endonuclease domain containing 1 (ENDOD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH104282 (e-PCR)
- UniSTS:98607

RH11665 (e-PCR)
- UniSTS:74835

D11S3060 (e-PCR)
- UniSTS:152158

G20516 (e-PCR)
- UniSTS:74878

A005U34 (e-PCR)
- UniSTS:74879

D11S1261 (e-PCR)
- UniSTS:148354

D11S991 (e-PCR), detects polymorphism
- UniSTS:148105

D11S1788 (e-PCR), detects polymorphism
- UniSTS:58775

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: endonuclease domain-containing 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015036.3 → NP_055851.1 endonuclease domain-containing 1 protein precursor

See identical proteins and their annotated locations for NP_055851.1

Status: VALIDATED

Source sequence(s)

AP000787, BC071171, DA050413

Consensus CDS

CCDS41699.1

UniProtKB/Swiss-Prot

A8K6K8, O94919, Q6GQY5, Q8TAQ8

Related

ENSP00000278505.4, ENST00000278505.5

Conserved Domains (1) summary

cl00089
Location:65 → 281

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.