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    Tmprss9 transmembrane protease, serine 9 [ Mus musculus (house mouse) ]

    Gene ID: 432478, updated on 9-Aug-2024

    Summary

    Official Symbol
    Tmprss9provided by MGI
    Official Full Name
    transmembrane protease, serine 9provided by MGI
    Primary source
    MGI:MGI:3612246
    See related
    Ensembl:ENSMUSG00000059406 AllianceGenome:MGI:3612246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Serase-1B
    Summary
    Enables serine-type peptidase activity. Acts upstream of or within plasminogen activation. Used to study autism spectrum disorder. Orthologous to human TMPRSS9 (transmembrane serine protease 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 19.4), testis adult (RPKM 1.4) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Tmprss9 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80706951..80735329)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80871117..80899495)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    transmembrane protease serine 9
    Names
    polyserase-1
    polyserase-I
    polyserine protease-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081688.2NP_001075157.2  transmembrane protease serine 9

      Status: VALIDATED

      Source sequence(s)
      AC152413, AC166937
      Consensus CDS
      CCDS48641.1
      UniProtKB/TrEMBL
      B2RY54, D3YTR8
      Related
      ENSMUSP00000100970.3, ENSMUST00000105333.3
      Conserved Domains (4) summary
      smart00020
      Location:238467
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:190225
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:239467
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:68148
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80706951..80735329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513843.2XP_006513906.2  transmembrane protease serine 9 isoform X2

      UniProtKB/TrEMBL
      B2RY54
      Conserved Domains (4) summary
      smart00020
      Location:748976
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:407442
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:10771328
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:285365
      SEA; SEA domain
    2. XM_006513842.2XP_006513905.2  transmembrane protease serine 9 isoform X1

      UniProtKB/TrEMBL
      B2RY54
      Conserved Domains (4) summary
      smart00020
      Location:455684
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:407442
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:10851336
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:285365
      SEA; SEA domain
    3. XM_006513845.2XP_006513908.2  transmembrane protease serine 9 isoform X4

      UniProtKB/TrEMBL
      B2RY54
      Conserved Domains (4) summary
      smart00020
      Location:455684
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:407442
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:10851310
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:285365
      SEA; SEA domain
    4. XM_006513844.2XP_006513907.2  transmembrane protease serine 9 isoform X3

      UniProtKB/TrEMBL
      B2RY54
      Conserved Domains (3) summary
      smart00020
      Location:441670
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:393428
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01390
      Location:285365
      SEA; SEA domain