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    Fbxl22 F-box and leucine-rich repeat protein 22 [ Mus musculus (house mouse) ]

    Gene ID: 74165, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fbxl22provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 22provided by MGI
    Primary source
    MGI:MGI:1921415
    See related
    Ensembl:ENSMUSG00000050503 AllianceGenome:MGI:1921415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110004B15Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and entrainment of circadian clock by photoperiod. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Z disc and nucleolus. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adipose tissue; genitourinary system; gut; musculature; and nervous system. Orthologous to human FBXL22 (F-box and leucine rich repeat protein 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 40.9), bladder adult (RPKM 35.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl22 in Genome Data Viewer
    Location:
    9 C; 9 35.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66415738..66425752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66508459..66514593, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6759 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66213808-66214109 Neighboring gene predicted gene, 30447 Neighboring gene predicted gene, 50499 Neighboring gene predicted gene, 23428 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66312941-66313241 Neighboring gene STARR-positive B cell enhancer ABC_E3841 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66351571-66351871 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66440763-66441064 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66444915-66445215 Neighboring gene STARR-positive B cell enhancer ABC_E2900 Neighboring gene STARR-seq mESC enhancer starr_24480 Neighboring gene STARR-positive B cell enhancer ABC_E11413 Neighboring gene carbonic anhydrase 12 Neighboring gene STARR-positive B cell enhancer ABC_E8296 Neighboring gene aph1 homolog B, gamma secretase subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase. Hughes DC, et al. Am J Physiol Cell Physiol, 2020 Oct 1. PMID 32783651
    2. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Spaich S, et al. Circ Res, 2012 Dec 7. PMID 22972877
    3. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267
    4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase.
      Title: Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box and leucine-rich protein 22
    Names
    F-box/LRR-repeat protein 22
    NP_780415.1
    XP_036011252.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175206.4 → NP_780415.1  F-box and leucine-rich protein 22

      See identical proteins and their annotated locations for NP_780415.1

      Status: VALIDATED

      Source sequence(s)
      AK003404, AK052175
      Consensus CDS
      CCDS23304.1
      UniProtKB/Swiss-Prot
      Q8C3G3, Q8C3V6, Q8C7B6
      UniProtKB/TrEMBL
      A0A6M4C800
      Related
      ENSMUSP00000060137.8, ENSMUST00000056890.10
      Conserved Domains (3) summary
      cd09293
      Location:45 → 200
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:116 → 141
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3 → 43
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66415738..66425752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155359.1 → XP_036011252.1  F-box and leucine-rich protein 22 isoform X1

      UniProtKB/Swiss-Prot
      Q8C3G3, Q8C3V6, Q8C7B6
      UniProtKB/TrEMBL
      A0A6M4C800
      Conserved Domains (3) summary
      cd09293
      Location:45 → 200
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:116 → 141
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3 → 43
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7B6.1 GenPept UniProtKB/Swiss-Prot:Q8C7B6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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