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    GPR55 G protein-coupled receptor 55 [ Homo sapiens (human) ]

    Gene ID: 9290, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR55provided by HGNC
    Official Full Name
    G protein-coupled receptor 55provided by HGNC
    Primary source
    HGNC:HGNC:4511
    See related
    Ensembl:ENSG00000135898 MIM:604107; AllianceGenome:HGNC:4511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPIR1
    Summary
    This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in testis (RPKM 2.7), spleen (RPKM 2.0) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR55 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230907328..230961201, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (231390497..231444798, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231772043..231789957, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231728341-231728999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231729658-231730316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231730317-231730973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734265-231734922 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734923-231735580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231742513-231743287 Neighboring gene integral membrane protein 2C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231757691-231758270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231758271-231758850 Neighboring gene GPR55 cis regulatory suppressor of immune response RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12419 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231773167-231774366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231789302-231790090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231804174-231804714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231804715-231805254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12422 Neighboring gene COX20 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17272 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231850196-231850380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231851885-231852384 Neighboring gene SPATA3 antisense RNA 1 (head to head) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231860347-231860880 Neighboring gene spermatogenesis associated 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The atypical cannabinoid O-1602: targets, actions, and the central nervous system. Ashton JC. Cent Nerv Syst Agents Med Chem, 2012 Sep. PMID 22831390
    2. Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55. Henstridge CM, et al. Mol Endocrinol, 2011 Nov. PMID 21964594, Free PMC Article
    3. Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. Anavi-Goffer S, et al. J Biol Chem, 2012 Jan 2. PMID 22027819, Free PMC Article
    4. The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. Moreno-Navarrete JM, et al. Diabetes, 2012 Feb. PMID 22179809, Free PMC Article
    5. Lysophosphatidylinositol signalling: new wine from an old bottle. Piñeiro R, et al. Biochim Biophys Acta, 2012 Apr. PMID 22285325

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulation of PI3K/Akt/GSK3beta signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.
      Title: Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.
    2. Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells.
      Title: Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells.
    3. A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma.
      Title: A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma.
    4. Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages.
      Title: Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages.
    5. Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.
      Title: Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.
    6. Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma.
      Title: Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma.
    7. Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
      Title: Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
    8. Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation.
      Title: Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation.
    9. Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages.
      Title: Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages.
    10. Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P5 in live cells.
      Title: Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.
    Submit: New GeneRIF Correction See all GeneRIFs (68)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 55 (GPR55) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cannabinoid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cannabinoid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in bone resorption IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cannabinoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050956.1 RefSeqGene

      Range
      40986..58900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005683.4 → NP_005674.2  G-protein coupled receptor 55

      See identical proteins and their annotated locations for NP_005674.2

      Status: REVIEWED

      Source sequence(s)
      AC012507, BC032694
      Consensus CDS
      CCDS2480.1
      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858
      Related
      ENSP00000498258.1, ENST00000650999.1
      Conserved Domains (1) summary
      cd15165
      Location:21 → 299
      7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      230907328..230961201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512175.4 → XP_011510477.1  G-protein coupled receptor 55 isoform X1

      See identical proteins and their annotated locations for XP_011510477.1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858
      Related
      ENSP00000375893.2, ENST00000392039.2
      Conserved Domains (1) summary
      cd15165
      Location:21 → 299
      7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_011512176.3 → XP_011510478.1  G-protein coupled receptor 55 isoform X1

      See identical proteins and their annotated locations for XP_011510478.1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858
      Conserved Domains (1) summary
      cd15165
      Location:21 → 299
      7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_005246952.5 → XP_005247009.1  G-protein coupled receptor 55 isoform X1

      See identical proteins and their annotated locations for XP_005247009.1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858
      Conserved Domains (1) summary
      cd15165
      Location:21 → 299
      7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      231390497..231444798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344568.1 → XP_054200543.1  G-protein coupled receptor 55 isoform X1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858

    2. XM_054344569.1 → XP_054200544.1  G-protein coupled receptor 55 isoform X1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858

    3. XM_054344567.1 → XP_054200542.1  G-protein coupled receptor 55 isoform X1

      UniProtKB/Swiss-Prot
      Q8N580, Q9Y2T6
      UniProtKB/TrEMBL
      A0A024R484, A8K858
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2T6.2 GenPept UniProtKB/Swiss-Prot:Q9Y2T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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