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    PRR36 proline rich 36 [ Homo sapiens (human) ]

    Gene ID: 80164, updated on 26-Nov-2024

    Summary

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    Official Symbol
    PRR36provided by HGNC
    Official Full Name
    proline rich 36provided by HGNC
    Primary source
    HGNC:HGNC:26172
    See related
    Ensembl:ENSG00000183248 AllianceGenome:HGNC:26172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]
    Expression
    Biased expression in brain (RPKM 7.2), prostate (RPKM 1.1) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR36 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7868719..7874390, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7869675..7875346, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7933605..7939275, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13901 Neighboring gene exosome component 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9991 Neighboring gene ecotropic viral integration site 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7912355-7912856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7922203-7922988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7926271-7926910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7926911-7927548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7928643-7929351 Neighboring gene Sharpr-MPRA regulatory region 2174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7933728-7934489 Neighboring gene Sharpr-MPRA regulatory region 8899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7938477-7938993 Neighboring gene LYPLA2 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage. Hänle-Kreidler S, et al. J Biol Chem, 2022 Dec. PMID 36395886, Free PMC Article
    2. Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization. Cristea I, et al. FEBS Lett, 2021 Dec. PMID 34674267
    3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
    4. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Müller PM, et al. Nat Cell Biol, 2020 Apr. PMID 32203420
    5. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Wheat A, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34349018, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    proline-rich protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033809.1 RefSeqGene

      Range
      5052..10723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190467.2 → NP_001177396.1  proline-rich protein 36

      See identical proteins and their annotated locations for NP_001177396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC010336, AL537525, KF459711
      Consensus CDS
      CCDS74276.1
      UniProtKB/Swiss-Prot
      A0A087WZ52, Q9H3X1, Q9H6K5
      Related
      ENSP00000482374.1, ENST00000618550.5
      Conserved Domains (1) summary
      pfam15363
      Location:1303 → 1346
      DUF4596; Domain of unknown function (DUF4596)

    RNA

    1. NR_104345.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon and lacks an internal segment, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AC010336, BE791180, BX452280

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7868719..7874390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7869675..7875346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080403.1: Suppressed sequence

      Description
      NM_001080403.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    2. NM_025094.1: Suppressed sequence

      Description
      NM_025094.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6K5.2 GenPept UniProtKB/Swiss-Prot:Q9H6K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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