KIF20A kinesin family member 20A [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF20Aprovided by HGNC
Official Full Name: kinesin family member 20Aprovided by HGNC
Primary source: HGNC:HGNC:9787
See related: Ensembl:ENSG00000112984 MIM:605664; AllianceGenome:HGNC:9787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RCM6; MKLP2; RAB6KIFL
Summary: Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including intercellular bridge; midbody; and spindle. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 7.6), bone marrow (RPKM 5.2) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (138179112..138187723)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (138705404..138714015)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (137514801..137523412)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1alpha Axis.
Title: KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1α Axis.
Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis.
Title: Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis.
Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas.
Title: Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas.
High expression of KIF20A in bladder cancer as a potential prognostic target for poor survival of renal cell carcinoma.
Title: High expression of KIF20A in bladder cancer as a potential prognostic target for poor survival of renal cell carcinoma.
KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway.
Title: KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway.
MKLP2 functions in early mitosis to ensure proper chromosome congression.
Title: MKLP2 functions in early mitosis to ensure proper chromosome congression.
The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor.
Title: The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor.
Low expression of KIF20A suppresses cell proliferation, promotes chemosensitivity and is associated with better prognosis in HCC.
Title: Low expression of KIF20A suppresses cell proliferation, promotes chemosensitivity and is associated with better prognosis in HCC.
The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
MKLP2 Is a Motile Kinesin that Transports the Chromosomal Passenger Complex during Anaphase.
Title: MKLP2 Is a Motile Kinesin that Transports the Chromosomal Passenger Complex during Anaphase.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cardiomyopathy, familial restrictive, 6 MedGen: C5543638 OMIM: 619433 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-14323 (e-PCR)
- UniSTS:83278

RH48412 (e-PCR)
- UniSTS:13253

RH48651 (e-PCR)
- UniSTS:79834

RH91186 (e-PCR)
- UniSTS:85223

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in midbody abscission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF20A

Names: GG10_2; RAB6 interacting, kinesin-like (rabkinesin6); mitotic kinesin-like protein 2; rab6-interacting kinesin-like protein; rabkinesin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.