GHET1 gastric carcinoma proliferation enhancing transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GHET1provided by HGNC
Official Full Name: gastric carcinoma proliferation enhancing transcript 1provided by HGNC
Primary source: HGNC:HGNC:49425
See related: Ensembl:ENSG00000281189 MIM:619888; AllianceGenome:HGNC:49425
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: lncRNA-GHET1
Summary: This gene encodes an unspliced long non-coding RNA that has been suggested to promote the proliferation of gastric carcinoma cells and bladder cancer cells. [provided by RefSeq, Dec 2014]
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Genomic context

Location:: 7q36.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (148987527..148989429)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (150169703..150171605)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (148684619..148686521)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA GHET1 promotes cell proliferation through oxidative stress in prostate cancer.
Title: Long noncoding RNA GHET1 promotes cell proliferation through oxidative stress in prostate cancer.
A review on the role of GHET1 in different cancers.
Title: A review on the role of GHET1 in different cancers.
LncRNA GHET1 promotes osteoblast proliferation and differentiation by inhibiting PTEN.
Title: LncRNA GHET1 promotes osteoblast proliferation and differentiation by inhibiting PTEN.
LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/beta-catenin signaling pathways.
Title: LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways.
Long noncoding RNA GHET1 promotes osteosarcoma development and progression via Wnt/betacatenin signaling pathway.
Title: Long non‑coding RNA GHET1 promotes osteosarcoma development and progression via Wnt/β‑catenin signaling pathway.
Knockdown of long non-coding RNA GHET1 suppresses cervical carcinoma in vitro and in vivo.
Title: Knockdown of long non-coding RNA GHET1 suppresses cervical carcinoma in vitro and in vivo.
Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.
Title: Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.
lncRNA GHET1 has effects in development of pre-eclampsia.
Title: lncRNA GHET1 has effects in development of pre-eclampsia.
The GHET1 might promote U251 cells by down-regulating miR-216a.
Title: Long non-coding RNA GHET1 promotes viability, migration and invasion of glioma cell line U251 by down-regulation of miR-216a.
Findings indicate that non-coding RNA gastric carcinoma high expressed transcript 1 (GHET1) interacted with von Hippel-Lindau (VHL) and up-regulated hypoxia inducible factor 1 subunit alpha (HIF1alpha).
Title: Long non-coding RNA GEHT1 promoted the proliferation of ovarian cancer cells via modulating the protein stability of HIF1α.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

gastric carcinoma high expressed transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.