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    TRIP13 thyroid hormone receptor interactor 13 [ Homo sapiens (human) ]

    Gene ID: 9319, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRIP13provided by HGNC
    Official Full Name
    thyroid hormone receptor interactor 13provided by HGNC
    Primary source
    HGNC:HGNC:12307
    See related
    Ensembl:ENSG00000071539 MIM:604507; AllianceGenome:HGNC:12307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MVA3; OOMD9; 16E1BP; OZEMA9
    Summary
    This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIP13 in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (892884..919348)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (798936..824664)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (892999..918235)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene bromodomain containing 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene Sharpr-MPRA regulatory region 1606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:916909-917478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:918895-919438 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:919439-919982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15879 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:929600-929776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22303 Neighboring gene uncharacterized LOC124900931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:965451-965952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:991246-991960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:994888-995388 Neighboring gene long intergenic non-protein coding RNA 2982

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TRIP13 Induces Nedaplatin Resistance in Esophageal Squamous Cell Carcinoma by Enhancing Repair of DNA Damage and Inhibiting Apoptosis. Zhang LT, et al. Biomed Res Int, 2022. PMID 35601150, Free PMC Article
    2. TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint. Ma HT, et al. Cell Rep, 2016 Feb 9. PMID 26832417
    3. [Regulation of TRIP13 on Proliferation and Apoptosis of B-Cell Lymphoma Cells and Its Mechanism]. Yan SR, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Oct. PMID 34627428
    4. Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway. Gao Y, et al. Int J Biol Sci, 2019. PMID 31337978, Free PMC Article
    5. Loss of thyroid hormone receptor interactor 13 inhibits cell proliferation and survival in human chronic lymphocytic leukemia. Zhou K, et al. Oncotarget, 2017 Apr 11. PMID 28424416, Free PMC Article

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of TRIP13 in human cancer development.
      Title: Role of TRIP13 in human cancer development.
    2. TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21.
      Title: TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21.
    3. TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.
      Title: TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.
    4. High expression of TRIP13 is associated with tumor progression in H. pylori infection induced gastric cancer.
      Title: High expression of TRIP13 is associated with tumor progression in H. pylori infection induced gastric cancer.
    5. Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
      Title: Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
    6. Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
      Title: Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
    7. Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
      Title: Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
    8. TRIP13 overexpression promotes gefitinib resistance in nonsmall cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
      Title: TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
    9. MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
      Title: MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
    10. Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
      Title: Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Mosaic variegated aneuploidy syndrome 3
    MedGen: C4539839 OMIM: 617598 GeneReviews: Not available
    		not available
    Oocyte maturation defect 9
    MedGen: C5436599 OMIM: 619011 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, thyroid hormone receptor interactor 13 (TRIP13), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in female meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic recombination checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pachytene checkpoint protein 2 homolog
    Names
    16E1-BP
    HPV16 E1 protein binding protein
    SH3TC1/TRIP13 fusion
    TR-interacting protein 13
    TRIP-13
    human papillomavirus type 16 E1 protein-binding protein
    thyroid receptor-interacting protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166260.2 → NP_001159732.1  pachytene checkpoint protein 2 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122719, AK310376
      UniProtKB/TrEMBL
      H0YAL2
      Related
      ENST00000512024.5
      Conserved Domains (2) summary
      COG0464
      Location:136 → 289
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:175 → 285
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_004237.4 → NP_004228.1  pachytene checkpoint protein 2 homolog isoform 1

      See identical proteins and their annotated locations for NP_004228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122719, BC019294, BM999741, DB443523
      Consensus CDS
      CCDS3858.1
      UniProtKB/Swiss-Prot
      C9K0T3, D3DTC0, O15324, Q15645
      Related
      ENSP00000166345.3, ENST00000166345.8
      Conserved Domains (1) summary
      COG0464
      Location:136 → 360
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      892884..919348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514163.2 → XP_011512465.1  pachytene checkpoint protein 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_011512465.1

      UniProtKB/Swiss-Prot
      C9K0T3, D3DTC0, O15324, Q15645
      Conserved Domains (1) summary
      COG0464
      Location:136 → 360
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    2. XM_047417879.1 → XP_047273835.1  pachytene checkpoint protein 2 homolog isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      798936..824664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353801.1 → XP_054209776.1  pachytene checkpoint protein 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      C9K0T3, D3DTC0, O15324, Q15645

    2. XM_054353802.1 → XP_054209777.1  pachytene checkpoint protein 2 homolog isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15645.2 GenPept UniProtKB/Swiss-Prot:Q15645

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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