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    STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 55359, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STYK1provided by HGNC
    Official Full Name
    serine/threonine/tyrosine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:18889
    See related
    Ensembl:ENSG00000060140 MIM:611433; AllianceGenome:HGNC:18889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOK; SuRTK106
    Summary
    Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STYK1 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10618923..10674052, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10492227..10547157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771522..10826651, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240 Neighboring gene uncharacterized LOC112268104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer. Orang AV, et al. Asian Pac J Cancer Prev, 2014. PMID 25169509
    2. High Novel Oncogene with Kinase-Domain (NOK) Gene Expression is Associated with the Progression of Renal Cell Carcinoma. Cao Q, et al. Clin Lab, 2016. PMID 27012048
    3. NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression. Liu Y, et al. Biochem Biophys Res Commun, 2016 Sep 9. PMID 27444381
    4. Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo. Chen MY, et al. Tumour Biol, 2016 Oct. PMID 27542675
    5. STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling. Wang Z, et al. Sci Rep, 2016 Sep 15. PMID 27628214, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.
      Title: Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.
    2. NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.
      Title: NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.
    3. STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-beta1.
      Title: STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1.
    4. SMAD3 induces the transcription of STYK1 to promote epithelial-mesenchymal transition and to elicit paclitaxel resistance of ovarian cancer cells.
      Title: SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
    5. elevated serine threonine tyrosine kinase 1 (STYK1) or decreased serine peptidase inhibitor Kunitz type 2 (SPINT2/HAI-2) expression significantly correlated with poor prognosis, tumor invasion, and metastasis of NSCLC patients. STYK1 overexpression promoted NSCLC cells proliferation, migration, and invasion. STYK1 also induced epithelial-mesenchymal transition by E-cadherin downregulation and Snail upregulation.
      Title: STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
    6. Data suggest that regulating ferroptosis could be another cancerous mechanism of serine/threonine/tyrosine kinase 1 (STYK1).
      Title: STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.
    7. findings suggest that STYK1 is a critical regulator of tumor growth and metastasis.
      Title: STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
    8. Overexpression of STYK1 was significantly associated with increased cell proliferation, migratory capability, and invasive capability in vitro, as well as increased volume of tumor, weight of tumor, and number of pulmonary metastasesin hepatocellular carcinoma.
      Title: STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
    9. STYK1 plays an important role in glioma development and progression.
      Title: Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
    10. Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation.
      Title: NOK mediates glycolysis and nuclear PDC associated histone acetylation.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761P1010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase STYK1
    Names
    novel oncogene with kinase domain
    protein PK-unique
    NP_060893.2
    XP_005253474.1
    XP_011519038.1
    XP_011519039.1
    XP_011519040.1
    XP_047285055.1
    XP_054228427.1
    XP_054228428.1
    XP_054228429.1
    XP_054228430.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018423.3 → NP_060893.2  tyrosine-protein kinase STYK1

      See identical proteins and their annotated locations for NP_060893.2

      Status: VALIDATED

      Source sequence(s)
      AC021049, AF251059, AL353940
      Consensus CDS
      CCDS8629.1
      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Related
      ENSP00000075503.3, ENST00000075503.8
      Conserved Domains (2) summary
      pfam07714
      Location:117 → 380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118 → 381
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10618923..10674052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253417.3 → XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_005253474.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117 → 380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118 → 381
      PKc_like; Protein Kinases, catalytic domain

    2. XM_047429099.1 → XP_047285055.1  tyrosine-protein kinase STYK1 isoform X2

      UniProtKB/TrEMBL
      A0A0C5BIK5

    3. XM_011520736.2 → XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519038.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117 → 380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118 → 381
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011520738.3 → XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519040.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117 → 380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118 → 381
      PKc_like; Protein Kinases, catalytic domain

    5. XM_011520737.2 → XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519039.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117 → 380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118 → 381
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10492227..10547157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372452.1 → XP_054228427.1  tyrosine-protein kinase STYK1 isoform X1

      UniProtKB/TrEMBL
      A0A0C5BIK5

    2. XM_054372455.1 → XP_054228430.1  tyrosine-protein kinase STYK1 isoform X2

      UniProtKB/TrEMBL
      A0A0C5BIK5

    3. XM_054372453.1 → XP_054228428.1  tyrosine-protein kinase STYK1 isoform X1

      UniProtKB/TrEMBL
      A0A0C5BIK5

    4. XM_054372454.1 → XP_054228429.1  tyrosine-protein kinase STYK1 isoform X1

      UniProtKB/TrEMBL
      A0A0C5BIK5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6J9G0.4 GenPept UniProtKB/Swiss-Prot:Q6J9G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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