TRAF3 TNF receptor associated factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRAF3provided by HGNC
Official Full Name: TNF receptor associated factor 3provided by HGNC
Primary source: HGNC:HGNC:12033
See related: Ensembl:ENSG00000131323 MIM:601896; AllianceGenome:HGNC:12033
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118
Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in lymph node (RPKM 5.0), appendix (RPKM 4.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (102777449..102911500)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (97013797..97147747)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (103243786..103377837)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF3 loss-of-function reveals the noncanonical NF-kappaB pathway as a therapeutic target in diffuse large B cell lymphoma.
Title: TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.
FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
Title: FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-beta1-induced BEAS-2B Cell Injury.
Title: The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury.
Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
Title: Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
Title: TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
Title: Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
Title: LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Title: TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Title: Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.
Title: Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (140)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Herpes simplex encephalitis, susceptibility to, 3 MedGen: C3553868 OMIM: 614849 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells	PubMed
	tat	HIV-1 Tat-induced upregulation of microRNA 32 results in downregulation of TRAF3 in human microglial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482312

G15867 (e-PCR)
- UniSTS:12048

D14S272 (e-PCR), detects polymorphism
- UniSTS:45129

TRAF3_1584 (e-PCR)
- UniSTS:277842

TRAF3_v555 (e-PCR)
- UniSTS:277842

G35638 (e-PCR)
- UniSTS:2954

G35442 (e-PCR)
- UniSTS:44951

SGC34698 (e-PCR)
- UniSTS:9381

RH69049 (e-PCR)
- UniSTS:33196

NoName (e-PCR)
- UniSTS:486323

D14S272 (e-PCR), detects polymorphism
- UniSTS:29877

WI-13969 (e-PCR)
- UniSTS:60858

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioesterase binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
involved_in Toll signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IC Inferred by Curator more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine/threonine protein kinase complex	NAS Non-traceable Author Statement more info	PubMed
part_of ubiquitin ligase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: TNF receptor-associated factor 3

Names: CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3

NP_001186356.1

EC 2.3.2.27

NP_001372071.1

EC 2.3.2.27

NP_001372072.1

EC 2.3.2.27

NP_003291.2

EC 2.3.2.27

NP_663777.1

EC 2.3.2.27

NP_663778.1

EC 2.3.2.27

XP_011535418.1

EC 2.3.2.27

XP_011535419.1

EC 2.3.2.27

XP_011535420.1

EC 2.3.2.27

XP_016877106.1

EC 2.3.2.27

XP_016877107.1

EC 2.3.2.27

XP_016877108.1

EC 2.3.2.27

XP_016877109.1

EC 2.3.2.27

XP_047287694.1

EC 2.3.2.27

XP_047287695.1

EC 2.3.2.27

XP_047287696.1

EC 2.3.2.27

XP_047287697.1

EC 2.3.2.27

XP_047287698.1

EC 2.3.2.27

XP_054232638.1

EC 2.3.2.27

XP_054232639.1

EC 2.3.2.27

XP_054232640.1

EC 2.3.2.27

XP_054232641.1

EC 2.3.2.27

XP_054232642.1

EC 2.3.2.27

XP_054232643.1

EC 2.3.2.27

XP_054232644.1

EC 2.3.2.27

XP_054232645.1

EC 2.3.2.27

XP_054232646.1

EC 2.3.2.27

XP_054232647.1

EC 2.3.2.27

XP_054232648.1

EC 2.3.2.27

XP_054232649.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027973.1 RefSeqGene

Range

5001..139022

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_229

mRNA and Protein(s)

NM_001199427.2 → NP_001186356.1 TNF receptor-associated factor 3 isoform 3

See identical proteins and their annotated locations for NP_001186356.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region as compared to isoform 1.

Source sequence(s)

AK303172, AL117209, AL132801, BQ000015, U21092

Consensus CDS

CCDS55946.1

UniProtKB/Swiss-Prot

Q13114

Related

ENSP00000445998.1, ENST00000539721.5

Conserved Domains (4) summary

smart00184
Location:53 → 88

RING; Ring finger

cd03777
Location:295 → 480

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:136 → 190

zf-TRAF; TRAF-type zinc finger

pfam17082
Location:224 → 283

Spc29; Spindle Pole Component 29
NM_001385142.1 → NP_001372071.1 TNF receptor-associated factor 3 isoform 4

Status: REVIEWED

Source sequence(s)

AL117209, AL132801

Conserved Domains (4) summary

cd03777
Location:331 → 516

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

cd16640
Location:51 → 92

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:197 → 247

zf-TRAF; TRAF-type zinc finger
NM_001385143.1 → NP_001372072.1 TNF receptor-associated factor 3 isoform 5

Status: REVIEWED

Source sequence(s)

AL117209, AL132801

Related

ENST00000699895.1

Conserved Domains (4) summary

COG1196
Location:225 → 406

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:351 → 536

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:136 → 190

zf-TRAF; TRAF-type zinc finger

cd16640
Location:51 → 92

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
NM_003300.4 → NP_003291.2 TNF receptor-associated factor 3 isoform 1

See identical proteins and their annotated locations for NP_003291.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AL117209, AL132801, BQ000015, BX247977, U21092

Consensus CDS

CCDS9975.1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

Related

ENSP00000454207.1, ENST00000560371.5

Conserved Domains (5) summary

cd03777
Location:378 → 563

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

pfam15272
Location:263 → 321

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17082
Location:307 → 366

Spc29; Spindle Pole Component 29
NM_145725.3 → NP_663777.1 TNF receptor-associated factor 3 isoform 1

See identical proteins and their annotated locations for NP_663777.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AL117209, AL132801, BQ000015, BX247977, U21092

Consensus CDS

CCDS9975.1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

Related

ENSP00000376500.3, ENST00000392745.8

Conserved Domains (5) summary

cd03777
Location:378 → 563

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

pfam15272
Location:263 → 321

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17082
Location:307 → 366

Spc29; Spindle Pole Component 29
NM_145726.3 → NP_663778.1 TNF receptor-associated factor 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.

Source sequence(s)

AL117209, AL132801, BQ000015, BX247977, U21092

Consensus CDS

CCDS9976.1

UniProtKB/TrEMBL

A6NHG8

Related

ENSP00000332468.5, ENST00000351691.10

Conserved Domains (4) summary

cd03777
Location:353 → 538

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

TIGR04527
Location:235 → 361

mycoplas_twoTM; two transmembrane protein

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

102777449..102911500

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537117.4 → XP_011535419.1 TNF receptor-associated factor 3 isoform X4

Conserved Domains (4) summary

cd03777
Location:322 → 507

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

pfam17082
Location:251 → 310

Spc29; Spindle Pole Component 29
XM_011537116.4 → XP_011535418.1 TNF receptor-associated factor 3 isoform X3

Conserved Domains (4) summary

smart00184
Location:53 → 88

RING; Ring finger

cd03777
Location:326 → 511

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

TIGR04527
Location:208 → 334

mycoplas_twoTM; two transmembrane protein

pfam02176
Location:136 → 190

zf-TRAF; TRAF-type zinc finger
XM_011537118.4 → XP_011535420.1 TNF receptor-associated factor 3 isoform X5

See identical proteins and their annotated locations for XP_011535420.1

UniProtKB/Swiss-Prot

Q13114

Conserved Domains (4) summary

smart00184
Location:53 → 88

RING; Ring finger

cd03777
Location:295 → 480

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:136 → 190

zf-TRAF; TRAF-type zinc finger

pfam17082
Location:224 → 283

Spc29; Spindle Pole Component 29
XM_047431739.1 → XP_047287695.1 TNF receptor-associated factor 3 isoform X2

UniProtKB/TrEMBL

A6NHG8
XM_047431742.1 → XP_047287698.1 TNF receptor-associated factor 3 isoform X4
XM_047431740.1 → XP_047287696.1 TNF receptor-associated factor 3 isoform X3
XM_017021620.3 → XP_016877109.1 TNF receptor-associated factor 3 isoform X6
XM_017021617.2 → XP_016877106.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

Conserved Domains (5) summary

cd03777
Location:378 → 563

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

pfam15272
Location:263 → 321

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17082
Location:307 → 366

Spc29; Spindle Pole Component 29
XM_047431738.1 → XP_047287694.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
XM_017021618.2 → XP_016877107.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

Related

ENSP00000514678.1, ENST00000699894.1

Conserved Domains (5) summary

cd03777
Location:378 → 563

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger

pfam15272
Location:263 → 321

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17082
Location:307 → 366

Spc29; Spindle Pole Component 29
XM_017021619.2 → XP_016877108.1 TNF receptor-associated factor 3 isoform X2

UniProtKB/TrEMBL

A6NHG8

Related

ENSP00000514677.1, ENST00000699893.1

Conserved Domains (4) summary

cd03777
Location:353 → 538

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

TIGR04527
Location:235 → 361

mycoplas_twoTM; two transmembrane protein

pfam00097
Location:56 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:136 → 192

zf-TRAF; TRAF-type zinc finger
XM_047431741.1 → XP_047287697.1 TNF receptor-associated factor 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

97013797..97147747

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054376670.1 → XP_054232645.1 TNF receptor-associated factor 3 isoform X4
XM_054376668.1 → XP_054232643.1 TNF receptor-associated factor 3 isoform X3
XM_054376673.1 → XP_054232648.1 TNF receptor-associated factor 3 isoform X5
XM_054376667.1 → XP_054232642.1 TNF receptor-associated factor 3 isoform X2

UniProtKB/TrEMBL

A6NHG8
XM_054376672.1 → XP_054232647.1 TNF receptor-associated factor 3 isoform X4
XM_054376669.1 → XP_054232644.1 TNF receptor-associated factor 3 isoform X3
XM_054376674.1 → XP_054232649.1 TNF receptor-associated factor 3 isoform X6
XM_054376664.1 → XP_054232639.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
XM_054376665.1 → XP_054232640.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
XM_054376666.1 → XP_054232641.1 TNF receptor-associated factor 3 isoform X2

UniProtKB/TrEMBL

A6NHG8
XM_054376671.1 → XP_054232646.1 TNF receptor-associated factor 3 isoform X4
XM_054376663.1 → XP_054232638.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1