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    SCRN3 secernin 3 [ Homo sapiens (human) ]

    Gene ID: 79634, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SCRN3provided by HGNC
    Official Full Name
    secernin 3provided by HGNC
    Primary source
    HGNC:HGNC:30382
    See related
    Ensembl:ENSG00000144306 MIM:614967; AllianceGenome:HGNC:30382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SES3
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 5.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SCRN3 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174395730..174430071)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174884418..174918718)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175260458..175294799)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12125 Neighboring gene VISTA enhancer hs953 Neighboring gene Sharpr-MPRA regulatory region 8106 Neighboring gene Sp9 transcription factor Neighboring gene corepressor interacting with RBPJ, CIR1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175256788-175256952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175260886-175261386 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:175274337-175274938 Neighboring gene G protein-coupled receptor 155 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175351272-175351454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16774 Neighboring gene GPR155 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Way G, et al. Mol Biol Cell, 2002 Sep. PMID 12221138, Free PMC Article
    2. Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Speek M. Mol Cell Biol, 2001 Mar. PMID 11238933, Free PMC Article
    3. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
    5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23142, MGC149597

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secernin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193528.2 → NP_001180457.1  secernin-3 isoform 2

      See identical proteins and their annotated locations for NP_001180457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' coding region, which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA227619, AK295357, BC031821, CK301138, DA760451
      Consensus CDS
      CCDS54420.1
      UniProtKB/Swiss-Prot
      Q0VDG4
      Related
      ENSP00000387142.3, ENST00000409673.7
      Conserved Domains (1) summary
      cl00467
      Location:48 → 219
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. NM_001412202.1 → NP_001399131.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    3. NM_001412203.1 → NP_001399132.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    4. NM_001412204.1 → NP_001399133.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    5. NM_001412205.1 → NP_001399134.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    6. NM_001412206.1 → NP_001399135.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    7. NM_001412207.1 → NP_001399136.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    8. NM_001412208.1 → NP_001399137.1  secernin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018470
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5

    9. NM_001412209.1 → NP_001399138.1  secernin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC018470

    10. NM_001412210.1 → NP_001399139.1  secernin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC018470

    11. NM_001412212.1 → NP_001399141.1  secernin-3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (5) has a frameshifted C-terminus compared to isoform 1.
      Source sequence(s)
      CP068276
      UniProtKB/TrEMBL
      Q0VDG5

    12. NM_024583.5 → NP_078859.2  secernin-3 isoform 1

      See identical proteins and their annotated locations for NP_078859.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses the same exon combination as variant 12 but represents the allele encoded by the GRCh38 reference genome. The encoded isoform (1) has a frameshifted C-terminus compared to isoform 5.
      Source sequence(s)
      AA227619, BC031821, BC119684, CK301138, DA760451
      Consensus CDS
      CCDS2258.1
      UniProtKB/Swiss-Prot
      B4DI11, C9JPC1, D3DPE0, Q0VDG4, Q7L1C5, Q9H5R5
      Related
      ENSP00000272732.6, ENST00000272732.11
      Conserved Domains (1) summary
      cl00467
      Location:5 → 226
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      174395730..174430071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      174884418..174918718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VDG4.1 GenPept UniProtKB/Swiss-Prot:Q0VDG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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