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    MEMO1 mediator of cell motility 1 [ Homo sapiens (human) ]

    Gene ID: 51072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEMO1provided by HGNC
    Official Full Name
    mediator of cell motility 1provided by HGNC
    Primary source
    HGNC:HGNC:14014
    See related
    Ensembl:ENSG00000162959 MIM:611786; AllianceGenome:HGNC:14014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEMO; C2orf4; CGI-27; NS5ATP7
    Summary
    Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 22.5), bone marrow (RPKM 10.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEMO1 in Genome Data Viewer
    Location:
    2p22.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (31867823..32011008, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (31916231..32059416, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32092892..32236077, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 52 Neighboring gene adenylate kinase 2 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:32111667-32112574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11332 Neighboring gene MPRA-validated peak3645 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209277-32209778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209779-32210278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32225693-32226193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11336 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32236012-32236171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15556 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15557 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32288537-32289337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11339 Neighboring gene spastin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MEMO1 binds iron and modulates iron homeostasis in cancer cells. Dolgova N, et al. Elife, 2024 Apr 19. PMID 38640016, Free PMC Article
    2. Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease. Schotanus MD, et al. Genes (Basel), 2020 Nov 6. PMID 33172038, Free PMC Article
    3. WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity. Wei X, et al. Cancer Lett, 2023 Mar 1. PMID 36627049
    4. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Zhang X, et al. Proc Natl Acad Sci U S A, 2022 Sep 13. PMID 36067318, Free PMC Article
    5. MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells. Sorokin AV, et al. Oncogene, 2013 Jun 27. PMID 22824790

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEMO1 binds iron and modulates iron homeostasis in cancer cells.
      Title: MEMO1 binds iron and modulates iron homeostasis in cancer cells.
    2. WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity.
      Title: WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity.
    3. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
      Title: Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
    4. miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
      Title: miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
    5. Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
      Title: Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
    6. Memo1 is a mediator of radial glial cell scaffold tiling, necessary to generate and organize neurons into functional ensembles in the developing cerebral cortex.
      Title: Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
    7. Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation.
      Title: Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.
    8. HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer
      Title: HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
    10. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration.
      Title: Memo is a copper-dependent redox protein with an essential role in migration and metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25031, DKFZp434I0135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    protein MEMO1
    Names
    C21orf19-like protein
    HCV NS5A-transactivated protein 7
    hepatitis C virus NS5A-transactivated protein 7
    mediator of ErbB2-driven cell motility 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137602.4 → NP_001131074.1  protein MEMO1 isoform 2

      See identical proteins and their annotated locations for NP_001131074.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS46255.1
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000400795.2, ENST00000426310.6
      Conserved Domains (1) summary
      cd07361
      Location:9 → 271
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    2. NM_001301833.4 → NP_001288762.1  protein MEMO1 isoform 1

      See identical proteins and their annotated locations for NP_001288762.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000385557.1, ENST00000404530.6
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    3. NM_001301852.4 → NP_001288781.1  protein MEMO1 isoform 3

      See identical proteins and their annotated locations for NP_001288781.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/Swiss-Prot
      Q9Y316
      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    4. NM_001371912.2 → NP_001358841.1  protein MEMO1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:9 → 334
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    5. NM_001371913.2 → NP_001358842.1  protein MEMO1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:18 → 303
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    6. NM_001371914.2 → NP_001358843.1  protein MEMO1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000368691.3, ENST00000379383.7
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    7. NM_001371916.2 → NP_001358845.1  protein MEMO1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS46255.1
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:9 → 271
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    8. NM_001371917.2 → NP_001358846.1  protein MEMO1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    9. NM_001371918.2 → NP_001358847.1  protein MEMO1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    10. NM_001371920.2 → NP_001358849.1  protein MEMO1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cd07361
      Location:9 → 196
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    11. NM_001371921.2 → NP_001358850.1  protein MEMO1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:102 → 186
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    12. NM_001385196.1 → NP_001372125.1  protein MEMO1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cd07361
      Location:103 → 388
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    13. NM_015955.5 → NP_057039.1  protein MEMO1 isoform 1

      See identical proteins and their annotated locations for NP_057039.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000295065.4, ENST00000295065.9
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    RNA

    1. NR_126032.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    2. NR_126034.4 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Related
      ENST00000490459.5

    3. NR_163995.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    4. NR_163996.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    5. NR_163997.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    6. NR_163998.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      31867823..32011008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444636.1 → XP_047300592.1  protein MEMO1 isoform X2

    2. XM_047444635.1 → XP_047300591.1  protein MEMO1 isoform X1

      UniProtKB/TrEMBL
      A8K3Y8

    3. XM_011532896.3 → XP_011531198.1  protein MEMO1 isoform X2

      See identical proteins and their annotated locations for XP_011531198.1

      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      31916231..32059416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342390.1 → XP_054198365.1  protein MEMO1 isoform X2

    2. XM_054342389.1 → XP_054198364.1  protein MEMO1 isoform X1

      UniProtKB/TrEMBL
      A8K3Y8

    3. XM_054342391.1 → XP_054198366.1  protein MEMO1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001371915.1: Suppressed sequence

      Description
      NM_001371915.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y316.1 GenPept UniProtKB/Swiss-Prot:Q9Y316

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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