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    RWDD4 RWD domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 201965, updated on 19-Sep-2024

    Summary

    Official Symbol
    RWDD4provided by HGNC
    Official Full Name
    RWD domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:23750
    See related
    Ensembl:ENSG00000182552 AllianceGenome:HGNC:23750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM28A; RWDD4A
    Expression
    Ubiquitous expression in adrenal (RPKM 29.0), ovary (RPKM 20.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RWDD4 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (183639635..183659185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (186982826..187002381, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184560788..184580338, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377580 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22185 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:184579545-184580333 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:184580334-184581121 Neighboring gene RNA, U6 small nuclear 479, pseudogene Neighboring gene trafficking protein particle complex subunit 11 Neighboring gene RNA, U6 small nuclear 335, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:184614366-184615565 Neighboring gene RNA, U6 small nuclear 1053, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    RWD domain-containing protein 4
    Names
    RWD domain containing 4A
    RWD domain-containing protein 4A
    family with sequence similarity 28, member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307922.2NP_001294851.1  RWD domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001294851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC108477, AK315515, AL540937, AL559547, BC017472, BQ185399, DA250301, DA766837
      Consensus CDS
      CCDS77986.1
      UniProtKB/TrEMBL
      E7EV43
      Related
      ENSP00000423598.1, ENST00000512740.1
      Conserved Domains (1) summary
      cl02687
      Location:644
      RWD; RWD domain
    2. NM_152682.4NP_689895.2  RWD domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_689895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108477, AK315515, AL540937, BC017472, BQ185399, DA250301, DA766837
      Consensus CDS
      CCDS34111.1
      UniProtKB/Swiss-Prot
      B2RDE9, B4DDP2, Q6NW29, Q75LA9, Q8WVW2
      Related
      ENSP00000388920.2, ENST00000326397.10
      Conserved Domains (1) summary
      pfam05773
      Location:5107
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      183639635..183659185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449747.1XP_047305703.1  RWD domain-containing protein 4 isoform X1

    2. XM_047449748.1XP_047305704.1  RWD domain-containing protein 4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      186982826..187002381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349167.1XP_054205142.1  RWD domain-containing protein 4 isoform X1

    2. XM_054349168.1XP_054205143.1  RWD domain-containing protein 4 isoform X2