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    TSPY8 testis specific protein Y-linked 8 [ Homo sapiens (human) ]

    Gene ID: 728403, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TSPY8provided by HGNC
    Official Full Name
    testis specific protein Y-linked 8provided by HGNC
    Primary source
    HGNC:HGNC:37471
    See related
    Ensembl:ENSG00000229549 AllianceGenome:HGNC:37471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including gonadal mesoderm development; nucleosome assembly; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 34.5) See more
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    Genomic context

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    See TSPY8 in Genome Data Viewer
    Location:
    Yp11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9357797..9360593)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (8963923..8966719)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9195406..9198202)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 4 Neighboring gene family with sequence similarity 197 Y-linked member 8 Neighboring gene family with sequence similarity 197 Y-linked member 7 Neighboring gene testis specific protein Y-linked 7, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422
    2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific Y-encoded protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243721.2 → NP_001230650.1  testis-specific Y-encoded protein 8

      See identical proteins and their annotated locations for NP_001230650.1

      Status: VALIDATED

      Source sequence(s)
      AC006158
      Consensus CDS
      CCDS59533.1
      UniProtKB/Swiss-Prot
      H7BXJ3, P0CW00
      UniProtKB/TrEMBL
      Q540R4
      Related
      ENSP00000287721.9, ENST00000287721.13
      Conserved Domains (1) summary
      cl08298
      Location:126 → 288
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      9357797..9360593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272744.5 → XP_005272801.1  testis-specific Y-encoded protein 8 isoform X1

      UniProtKB/TrEMBL
      A6NGL4, Q540R4
      Related
      ENSP00000372462.1, ENST00000383000.1
      Conserved Domains (1) summary
      cl08298
      Location:103 → 273
      NAP; Nucleosome assembly protein (NAP)

    2. XM_011544005.3 → XP_011542307.1  testis-specific Y-encoded protein 8 isoform X2

      Conserved Domains (1) summary
      cl08298
      Location:112 → 223
      NAP; Nucleosome assembly protein (NAP)

    RNA

    1. XR_949064.3 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791821.1 Reference GRCh38.p14 PATCHES

      Range
      225079..227875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333422.1 → XP_054189397.1  testis-specific Y-encoded protein 8 isoform X1

      UniProtKB/TrEMBL
      A6NGL4, Q540R4

    2. XM_054333423.1 → XP_054189398.1  testis-specific Y-encoded protein 8 isoform X2

    RNA

    1. XR_008485841.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      8963923..8966719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328331.1 → XP_054184306.1  testis-specific Y-encoded protein 8 isoform X1

      UniProtKB/TrEMBL
      Q540R4

    2. XM_054328332.1 → XP_054184307.1  testis-specific Y-encoded protein 8 isoform X2

    RNA

    1. XR_008485527.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW00.2 GenPept UniProtKB/Swiss-Prot:P0CW00

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