CD79B CD79b molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD79Bprovided by HGNC
Official Full Name: CD79b moleculeprovided by HGNC
Primary source: HGNC:HGNC:1699
See related: Ensembl:ENSG00000007312 MIM:147245; AllianceGenome:HGNC:1699
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B29; IGB; AGM6; Igbeta
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (63928740..63932331, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (64799505..64803094, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (62006100..62009691, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
Title: CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
Prevalence and prognostic value of MYD88 and CD79B mutations in ocular adnexal large B-cell lymphoma: a reclassification of ocular adnexal large B-cell lymphoma.
Title: Prevalence and prognostic value of MYD88 and CD79B mutations in ocular adnexal large B-cell lymphoma: a reclassification of ocular adnexal large B-cell lymphoma.
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.
Title: Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.
The Prognostic Significance of CD79B Mutation in Diffuse Large B-Cell Lymphoma: A Meta-analysis and Systematic Literature Review.
Title: The Prognostic Significance of CD79B Mutation in Diffuse Large B-Cell Lymphoma: A Meta-analysis and Systematic Literature Review.
A New Missense Mutation in CD79B Leads to Autosomal Recessive Agammaglobulinemia in Two Siblings.
Title: A New Missense Mutation in CD79B Leads to Autosomal Recessive Agammaglobulinemia in Two Siblings.
Genetically, primary adrenal diffuse large B-cell lymphoma harbor a high prevalence of MYD88 L265P (24%) and CD79B mutations (52%) which may be involved in lymphomagenesis.
Title: Morphologic Patterns and the Correlation With MYD88 L265P, CD79B Mutations in Primary Adrenal Diffuse Large B-Cell Lymphoma.
primary vitreoretinal lymphoma had unique genetic features: an expression pattern different from activated B-cell type and relatively close to germinal center B-cell-type diffuse large B-cell lymphoma. CD79B mutations showed potential to serve as prognostic markers for CNS progression
Title: Gene expression profiling of primary vitreoretinal lymphoma.
MYD88, CARD11, and CD79B Oncogenic Mutations are Rare Events in the Indian Cohort of De Novo Nodal Diffuse Large B-Cell Lymphoma.
Title: MYD88, CARD11, and CD79B Oncogenic Mutations are Rare Events in the Indian Cohort of De Novo Nodal Diffuse Large B-Cell Lymphoma.
CD79B Y196 mutation occurs in 26% of patients with intravascular large B-cell lymphoma (IVLBCL) in Dutch study.
Title: High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma.
Detecting CD79B(Y196) in vitreous DNA may contribute to the confirmation of the diagnosis and may have a prognostic potential for patients with PVRL.
Title: CD79B mutations in primary vitreoretinal lymphoma: Diagnostic and prognostic potential.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Agammaglobulinemia 6, autosomal recessive MedGen: C3150207 OMIM: 612692 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells	PubMed
	env	SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

PMC83897P1 (e-PCR)
- UniSTS:273433

RH93822 (e-PCR)
- UniSTS:90981

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of B cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IgM B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: B-cell antigen receptor complex-associated protein beta chain

Names: B-cell-specific glycoprotein B29; CD79b antigen (immunoglobulin-associated beta); CD79b molecule, immunoglobulin-associated beta; Ig-beta; immunoglobulin-associated B29 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007368.1 RefSeqGene

Range

5001..8607

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_43

mRNA and Protein(s)

NM_000626.4 → NP_000617.1 B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

See identical proteins and their annotated locations for NP_000617.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3, but has identical N- and C- termini.

Source sequence(s)

AA804163, AC127029, M89957

Consensus CDS

CCDS11655.1

UniProtKB/Swiss-Prot

P40259, Q53FS2, Q9BU06

Related

ENSP00000006750.4, ENST00000006750.8

Conserved Domains (2) summary

smart00077
Location:193 → 212

ITAM; Immunoreceptor tyrosine-based activation motif

cd16096
Location:51 → 142

IgV_CD79b_beta; Immunoglobulin variable domain (IgV)
NM_001039933.3 → NP_001035022.1 B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor

See identical proteins and their annotated locations for NP_001035022.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AK222954

Consensus CDS

CCDS42372.1

UniProtKB/Swiss-Prot

P40259

Related

ENSP00000376544.3, ENST00000392795.7

Conserved Domains (3) summary

smart00077
Location:194 → 213

ITAM; Immunoreceptor tyrosine-based activation motif

smart00410
Location:51 → 143

IG_like; Immunoglobulin like

pfam07686
Location:49 → 143

V-set; Immunoglobulin V-set domain
NM_001329050.2 → NP_001315979.1 B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in its 5' coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.

Source sequence(s)

AC127029

Conserved Domains (1) summary

smart00077
Location:90 → 109

ITAM; Immunoreceptor tyrosine-based activation motif
NM_021602.4 → NP_067613.1 B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

See identical proteins and their annotated locations for NP_067613.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site and also lacks an exon in the coding region, compared to variant 3. The encoded isoform (2) is shorter compared to isoform 3, but has identical N- and C- termini.

Source sequence(s)

AK222954, M89957, X83539

Consensus CDS

CCDS11656.1

UniProtKB/Swiss-Prot

P40259

Related

ENSP00000245862.2, ENST00000349817.2

Conserved Domains (1) summary

smart00077
Location:89 → 108

ITAM; Immunoreceptor tyrosine-based activation motif