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    MYT1L myelin transcription factor 1 like [ Homo sapiens (human) ]

    Gene ID: 23040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MYT1Lprovided by HGNC
    Official Full Name
    myelin transcription factor 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:7623
    See related
    Ensembl:ENSG00000186487 MIM:613084; AllianceGenome:HGNC:7623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NZF1; MRD39; myT1-L; ZC2H2C2; ZC2HC4B
    Summary
    This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]
    Expression
    Biased expression in brain (RPKM 9.8) and testis (RPKM 1.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See MYT1L in Genome Data Viewer
    Location:
    2p25.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (1789113..2331275, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (1796915..2341550, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (1792885..2335047, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1640917-1641511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1643345-1644278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1661268-1661929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1681235-1682160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1690124-1690637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1690638-1691152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1696267-1696766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1698687-1699427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1708299-1708902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1708903-1709506 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1711357-1712002 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1712003-1712647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1713293-1713937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1714484-1714990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1714991-1715497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1716916-1717895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1731880-1732562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1732563-1733245 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:1734173-1734778 Neighboring gene peroxidasin Neighboring gene uncharacterized LOC124907724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1755052-1755552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1784798-1785298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1785299-1785799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:1805517-1806018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:1806019-1806518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1807745-1808377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1820106-1821018 Neighboring gene uncharacterized LOC124905967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1829865-1830422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1842467-1842968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1845570-1846224 Neighboring gene uncharacterized LOC107985838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1846879-1847533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1847534-1848187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1868997-1869620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1878441-1878941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1969195-1969716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1977845-1978345 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:1990006-1990664 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:1990665-1991322 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:2010989-2011490 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:2011491-2011992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2028319-2028820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2028821-2029320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2029757-2030573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2149801-2150324 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2150847-2151369 Neighboring gene NANOG hESC enhancer GRCh37_chr2:2252484-2253019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2276633-2277264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2295761-2296549 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2297557-2298056 Neighboring gene MYT1L antisense RNA 1 Neighboring gene uncharacterized LOC105373389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11105 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:2530602-2531801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2569029-2569986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2641129-2641629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2650988-2651602 Neighboring gene uncharacterized LOC107985839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2660703-2661676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2665611-2666112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. 2p25.3 microduplications involving MYT1L: further phenotypic characterization through an assessment of 16 new cases and a literature review. Bouassida M, et al. Eur J Hum Genet, 2023 Aug. PMID 37188826, Free PMC Article
    2. Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. Wang T, et al. PLoS One, 2010 Oct 27. PMID 21048971, Free PMC Article
    3. Induction of human neuronal cells by defined transcription factors. Pang ZP, et al. Nature, 2011 May 26. PMID 21617644, Free PMC Article
    4. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Li W, et al. Genes Brain Behav, 2012 Feb. PMID 21923761
    5. MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions. Stevens SJ, et al. Am J Med Genet A, 2011 Nov. PMID 21990140

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.
      Title: MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.
    2. 2p25.3 microduplications involving MYT1L: further phenotypic characterization through an assessment of 16 new cases and a literature review.
      Title: 2p25.3 microduplications involving MYT1L: further phenotypic characterization through an assessment of 16 new cases and a literature review.
    3. Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis.
      Title: Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis.
    4. MYT1L-associated neurodevelopmental disorder: description of 40 new cases and literature review of clinical and molecular aspects.
      Title: MYT1L-associated neurodevelopmental disorder: description of 40 new cases and literature review of clinical and molecular aspects.
    5. A web-based survey on various symptoms of computer vision syndrome and the genetic understanding based on a multi-trait genome-wide association study.
      Title: A web-based survey on various symptoms of computer vision syndrome and the genetic understanding based on a multi-trait genome-wide association study.
    6. The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
      Title: The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
    7. Nine newly identified individuals refine the phenotype associated with MYT1L mutations.
      Title: Nine newly identified individuals refine the phenotype associated with MYT1L mutations.
    8. MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism.
      Title: MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism.
    9. The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
      Title: The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
    10. Our finding supports the association of MYT1L mutations with early-onset syndromic obesity. The identification of novel monogenic forms of childhood-onset obesity will provide insights to the involved genetic and biologic pathways.
      Title: A novel MYT1L mutation in a patient with severe early-onset obesity and intellectual disability.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 39
    MedGen: C4225296 OMIM: 616521 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2017-03-09)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2017-03-09)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myelin transcription factor 1-like protein
    Names
    neural zinc finger transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051313.1 RefSeqGene

      Range
      5114..547276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303052.2 → NP_001289981.1  myelin transcription factor 1-like protein isoform 1

      See identical proteins and their annotated locations for NP_001289981.1

      Status: REVIEWED

      Source sequence(s)
      AC011301, AF036943, BC042833, BC137272, BC150281, DA248951
      Consensus CDS
      CCDS77378.1
      UniProtKB/Swiss-Prot
      A7E2C7, B2RP54, Q6IQ17, Q9UL68, Q9UPP6
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000497479.2, ENST00000647738.2
      Conserved Domains (3) summary
      COG1196
      Location:1033 → 1185
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    2. NM_001329844.2 → NP_001316773.1  myelin transcription factor 1-like protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS77378.1
      UniProtKB/Swiss-Prot
      A7E2C7, B2RP54, Q6IQ17, Q9UL68, Q9UPP6
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000396103.3, ENST00000428368.7
      Conserved Domains (3) summary
      COG1196
      Location:1033 → 1185
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    3. NM_001329845.1 → NP_001316774.1  myelin transcription factor 1-like protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS77378.1
      UniProtKB/Swiss-Prot
      A7E2C7, B2RP54, Q6IQ17, Q9UL68, Q9UPP6
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000497722.1, ENST00000647694.1
      Conserved Domains (3) summary
      COG1196
      Location:1033 → 1185
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    4. NM_001329846.3 → NP_001316775.1  myelin transcription factor 1-like protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390
      Consensus CDS
      CCDS92709.1
      UniProtKB/TrEMBL
      A0A3B3IRT9, A0A3B3IRX5
      Related
      ENSP00000496922.1, ENST00000647755.1
      Conserved Domains (3) summary
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam05667
      Location:890 → 1115
      DUF812; Protein of unknown function (DUF812)
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    5. NM_001329847.2 → NP_001316776.1  myelin transcription factor 1-like protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS46222.1
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000497017.1, ENST00000648928.1
      Conserved Domains (3) summary
      COG1196
      Location:1031 → 1183
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    6. NM_001329848.1 → NP_001316777.1  myelin transcription factor 1-like protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS46222.1
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000496986.1, ENST00000649207.1
      Conserved Domains (3) summary
      COG1196
      Location:1031 → 1183
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    7. NM_001329849.3 → NP_001316778.1  myelin transcription factor 1-like protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS92707.1
      UniProtKB/TrEMBL
      A0A3B3IRT9, A0A3B3IS61
      Related
      ENSP00000497115.1, ENST00000648665.2
      Conserved Domains (3) summary
      TIGR04211
      Location:1058 → 1136
      SH3_and_anchor; SH3 domain protein
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    8. NM_001329851.3 → NP_001316780.1  myelin transcription factor 1-like protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS92704.1
      UniProtKB/TrEMBL
      A0A3B3IRT9, A0A3B3ISW5
      Related
      ENSP00000497273.1, ENST00000649663.1
      Conserved Domains (1) summary
      COG1196
      Location:1059 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. NM_001329852.3 → NP_001316781.1  myelin transcription factor 1-like protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008276, AC009232, AC009471, AC011301, AC093390, BC042833
      Consensus CDS
      CCDS92706.1
      UniProtKB/TrEMBL
      A0A3B3IRM3, A0A3B3IRT9
      Related
      ENSP00000496831.1, ENST00000648318.1

    10. NM_015025.4 → NP_055840.2  myelin transcription factor 1-like protein isoform 2

      See identical proteins and their annotated locations for NP_055840.2

      Status: REVIEWED

      Source sequence(s)
      AC011301, BC042833, BC137272, BC150281, DA248951
      Consensus CDS
      CCDS46222.1
      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Related
      ENSP00000382114.3, ENST00000399161.8
      Conserved Domains (3) summary
      COG1196
      Location:1031 → 1183
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      1789113..2331275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510326.2 → XP_011508628.1  myelin transcription factor 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      TIGR04211
      Location:1060 → 1138
      SH3_and_anchor; SH3 domain protein
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    2. XM_011510324.3 → XP_011508626.1  myelin transcription factor 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A2R8YF72, A0A3B3ITJ8
      Related
      ENSP00000496210.1, ENST00000644820.1
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1
      pfam10267
      Location:1077 → 1149
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_011510318.2 → XP_011508620.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508620.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    4. XM_017003604.2 → XP_016859093.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    5. XM_017003612.2 → XP_016859101.1  myelin transcription factor 1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS14, A0A3B3ITJ8
      Related
      ENSP00000497068.1, ENST00000650485.2
      Conserved Domains (3) summary
      TIGR04211
      Location:1058 → 1136
      SH3_and_anchor; SH3 domain protein
      pfam01530
      Location:902 → 930
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    6. XM_017003606.2 → XP_016859095.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:923 → 949
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1073 → 1139
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    7. XM_011510319.2 → XP_011508621.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508621.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    8. XM_017003605.2 → XP_016859094.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    9. XM_011510322.3 → XP_011508624.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508624.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    10. XM_017003607.3 → XP_016859096.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:923 → 949
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1073 → 1139
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:619 → 870
      MYT1; Myelin transcription factor 1

    11. XM_011510320.4 → XP_011508622.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508622.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    12. XM_011510321.3 → XP_011508623.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508623.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    13. XM_011510323.1 → XP_011508625.1  myelin transcription factor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011508625.1

      UniProtKB/TrEMBL
      A0A3B3ITJ8
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    14. XM_017003620.1 → XP_016859109.1  myelin transcription factor 1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A3B3IS77
      Related
      ENSP00000497206.2, ENST00000648753.2
      Conserved Domains (3) summary
      pfam01530
      Location:827 → 853
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:977 → 1043
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:523 → 774
      MYT1; Myelin transcription factor 1

    15. XM_017003616.2 → XP_016859105.1  myelin transcription factor 1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A3B3IRT9
      Conserved Domains (3) summary
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam05667
      Location:892 → 1117
      DUF812; Protein of unknown function (DUF812)
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    16. XM_017003615.2 → XP_016859104.1  myelin transcription factor 1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A3B3IRT9
      Conserved Domains (3) summary
      TIGR04211
      Location:1060 → 1138
      SH3_and_anchor; SH3 domain protein
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    17. XM_011510328.3 → XP_011508630.1  myelin transcription factor 1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A3B3IRT9
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1
      pfam10267
      Location:1077 → 1149
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    18. XM_011510327.2 → XP_011508629.1  myelin transcription factor 1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A3B3IRT9
      Conserved Domains (3) summary
      pfam01530
      Location:925 → 951
      zf-C2HC; Zinc finger, C2HC type
      pfam05087
      Location:1075 → 1141
      Rota_VP2; Rotavirus VP2 protein
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    19. XM_017003608.2 → XP_016859097.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRT9

    20. XM_011510332.3 → XP_011508634.1  myelin transcription factor 1-like protein isoform X14

      UniProtKB/TrEMBL
      B4DS48
      Conserved Domains (2) summary
      pfam01530
      Location:30 → 56
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    21. XM_017003622.2 → XP_016859111.1  myelin transcription factor 1-like protein isoform X15

      UniProtKB/TrEMBL
      B4DS48
      Related
      ENSP00000498096.1, ENST00000649810.1

    22. XM_011510331.3 → XP_011508633.1  myelin transcription factor 1-like protein isoform X12

      UniProtKB/TrEMBL
      B4DS48
      Conserved Domains (2) summary
      pfam01530
      Location:882 → 907
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 872
      MYT1; Myelin transcription factor 1

    23. XM_017003621.2 → XP_016859110.1  myelin transcription factor 1-like protein isoform X13

      UniProtKB/TrEMBL
      B4DS48

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      1796915..2341550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341060.1 → XP_054197035.1  myelin transcription factor 1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS14, A0A3B3ITJ8

    2. XM_054341057.1 → XP_054197032.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    3. XM_054341059.1 → XP_054197034.1  myelin transcription factor 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    4. XM_054341056.1 → XP_054197031.1  myelin transcription factor 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A2R8YF72, A0A3B3ITJ8

    5. XM_054341048.1 → XP_054197023.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    6. XM_054341054.1 → XP_054197029.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    7. XM_054341049.1 → XP_054197024.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    8. XM_054341053.1 → XP_054197028.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    9. XM_054341052.1 → XP_054197027.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    10. XM_054341050.1 → XP_054197025.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    11. XM_054341051.1 → XP_054197026.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    12. XM_054341055.1 → XP_054197030.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITJ8

    13. XM_054341066.1 → XP_054197041.1  myelin transcription factor 1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A3B3IS77

    14. XM_054341065.1 → XP_054197040.1  myelin transcription factor 1-like protein isoform X16

      UniProtKB/TrEMBL
      A0A3B3IRT9, A0A3B3IRX5

    15. XM_054341064.1 → XP_054197039.1  myelin transcription factor 1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A3B3IRT9

    16. XM_054341063.1 → XP_054197038.1  myelin transcription factor 1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A3B3IRT9

    17. XM_054341062.1 → XP_054197037.1  myelin transcription factor 1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A3B3IRT9

    18. XM_054341061.1 → XP_054197036.1  myelin transcription factor 1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A3B3IRT9

    19. XM_054341058.1 → XP_054197033.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRT9

    20. XM_054341069.1 → XP_054197044.1  myelin transcription factor 1-like protein isoform X14

      UniProtKB/TrEMBL
      B4DS48

    21. XM_054341070.1 → XP_054197045.1  myelin transcription factor 1-like protein isoform X15

      UniProtKB/TrEMBL
      B4DS48

    22. XM_054341067.1 → XP_054197042.1  myelin transcription factor 1-like protein isoform X12

      UniProtKB/TrEMBL
      B4DS48

    23. XM_054341068.1 → XP_054197043.1  myelin transcription factor 1-like protein isoform X13

      UniProtKB/TrEMBL
      B4DS48
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UL68.3 GenPept UniProtKB/Swiss-Prot:Q9UL68

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