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    HNRNPR heterogeneous nuclear ribonucleoprotein R [ Homo sapiens (human) ]

    Gene ID: 10236, updated on 2-Nov-2024

    Summary

    Official Symbol
    HNRNPRprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Rprovided by HGNC
    Primary source
    HGNC:HGNC:5047
    See related
    Ensembl:ENSG00000125944 MIM:607201; AllianceGenome:HGNC:5047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPR; NEDDFSB; hnRNP-R
    Summary
    This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in lymph node (RPKM 17.7), appendix (RPKM 17.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HNRNPR in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23304688..23344284, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23137824..23177454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23631181..23670777, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak116 silencer Neighboring gene Sharpr-MPRA regulatory region 9970 Neighboring gene ribosomal protein L29 pseudogene 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23589770-23590604 Neighboring gene long intergenic non-protein coding RNA 1355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23670710-23671294 Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23683836-23684671 Neighboring gene Sharpr-MPRA regulatory region 11811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 361 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23697210-23697795 Neighboring gene ZNF436 antisense RNA 1 Neighboring gene zinc finger protein 436 Neighboring gene Sharpr-MPRA regulatory region 9848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 362 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23709609-23709825 Neighboring gene transcription elongation factor A3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23745635-23746193

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein R (HNRNPR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein R (HNRNPR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein R (HNRNPR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein R (HNRNPR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein R (HNRNPR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPR is increased by RRE PubMed
    rev HIV-1 Rev involves its amino acids 9-14 for specific binding to the heterogeneous nuclear ribonucleoproteins (hnRNP) R PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102397.3NP_001095867.1  heterogeneous nuclear ribonucleoprotein R isoform 4

      See identical proteins and their annotated locations for NP_001095867.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL109936, BC110389, BX647784
      UniProtKB/TrEMBL
      A0A6Q8PEX7, B4DMD1
      Related
      ENSP00000502301.2, ENST00000476451.3
      Conserved Domains (1) summary
      TIGR01648
      Location:5527
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    2. NM_001102398.3NP_001095868.1  heterogeneous nuclear ribonucleoprotein R isoform 1

      See identical proteins and their annotated locations for NP_001095868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL109936, BC001449, BX647784
      Consensus CDS
      CCDS44085.1
      UniProtKB/TrEMBL
      B2R7W4
      Related
      ENSP00000363745.3, ENST00000374616.7
      Conserved Domains (2) summary
      TIGR01648
      Location:106631
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    3. NM_001102399.3NP_001095869.1  heterogeneous nuclear ribonucleoprotein R isoform 3

      See identical proteins and their annotated locations for NP_001095869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL109936, BC110389, BX640912, BX647784
      Consensus CDS
      CCDS60020.1
      UniProtKB/TrEMBL
      B4DMD1
      Related
      ENSP00000474437.1, ENST00000478691.5
      Conserved Domains (1) summary
      TIGR01648
      Location:5530
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    4. NM_001297620.2NP_001284549.1  heterogeneous nuclear ribonucleoprotein R isoform 5

      See identical proteins and their annotated locations for NP_001284549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as R2) lacks an in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK297382, AL109936, BX647784, DA496215
      Consensus CDS
      CCDS72727.1
      UniProtKB/TrEMBL
      B4DMB1
      Related
      ENSP00000502509.2, ENST00000463552.6
      Conserved Domains (2) summary
      TIGR01648
      Location:106590
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    5. NM_001297621.2NP_001284550.1  heterogeneous nuclear ribonucleoprotein R isoform 7

      See identical proteins and their annotated locations for NP_001284550.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple exons in the 5' region and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AK297405, AL109936, AU126696, BX647784, DA496215
      UniProtKB/TrEMBL
      B4DMD1
      Conserved Domains (1) summary
      TIGR01648
      Location:5468
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    6. NM_001297622.2NP_001284551.1  heterogeneous nuclear ribonucleoprotein R isoform 6

      See identical proteins and their annotated locations for NP_001284551.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks multiple exons in the 5' region and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AK311519, AL109936, BC110389, BX647784, DA496215
      Consensus CDS
      CCDS72726.1
      UniProtKB/TrEMBL
      B4DMD1, B4DT28
      Related
      ENSP00000475760.1, ENST00000606561.5
      Conserved Domains (1) summary
      TIGR01648
      Location:5489
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    7. NM_005826.5NP_005817.1  heterogeneous nuclear ribonucleoprotein R isoform 2

      See identical proteins and their annotated locations for NP_005817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as R1) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF000364, AL109936, BX647784, DA496215
      Consensus CDS
      CCDS232.1
      UniProtKB/Swiss-Prot
      O43390, Q2L7G6, Q5TEH1, Q9BV64, S4R3J4
      UniProtKB/TrEMBL
      B2R7W4
      Related
      ENSP00000304405.6, ENST00000302271.11
      Conserved Domains (2) summary
      TIGR01648
      Location:106628
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23304688..23344284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540476.4XP_011538778.1  heterogeneous nuclear ribonucleoprotein R isoform X14

      See identical proteins and their annotated locations for XP_011538778.1

      UniProtKB/TrEMBL
      B4DMD1
      Conserved Domains (1) summary
      TIGR01648
      Location:5492
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    2. XM_011540477.4XP_011538779.1  heterogeneous nuclear ribonucleoprotein R isoform X15

      See identical proteins and their annotated locations for XP_011538779.1

      UniProtKB/TrEMBL
      B4DMD1
      Conserved Domains (1) summary
      TIGR01648
      Location:5471
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    3. XM_017000010.3XP_016855499.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0, B4DMB1
      Related
      ENSP00000502234.2, ENST00000470941.6
      Conserved Domains (2) summary
      TIGR01648
      Location:106569
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    4. XM_011540474.4XP_011538776.1  heterogeneous nuclear ribonucleoprotein R isoform X12

      See identical proteins and their annotated locations for XP_011538776.1

      UniProtKB/TrEMBL
      B4DMB1
      Conserved Domains (2) summary
      TIGR01648
      Location:106593
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    5. XM_017000009.3XP_016855498.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0, B4DMB1
      Conserved Domains (2) summary
      TIGR01648
      Location:106569
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    6. XM_005245711.6XP_005245768.1  heterogeneous nuclear ribonucleoprotein R isoform X6

      See identical proteins and their annotated locations for XP_005245768.1

      UniProtKB/Swiss-Prot
      O43390, Q2L7G6, Q5TEH1, Q9BV64, S4R3J4
      UniProtKB/TrEMBL
      B2R7W4
      Related
      ENSP00000363741.1, ENST00000374612.5
      Conserved Domains (2) summary
      TIGR01648
      Location:106628
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    7. XM_011540471.4XP_011538773.1  heterogeneous nuclear ribonucleoprotein R isoform X5

      See identical proteins and their annotated locations for XP_011538773.1

      UniProtKB/TrEMBL
      B2R7W4
      Conserved Domains (2) summary
      TIGR01648
      Location:106631
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins
    8. XM_047424931.1XP_047280887.1  heterogeneous nuclear ribonucleoprotein R isoform X9

    9. XM_047424758.1XP_047280714.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    10. XM_047424712.1XP_047280668.1  heterogeneous nuclear ribonucleoprotein R isoform X2

    11. XM_047424890.1XP_047280846.1  heterogeneous nuclear ribonucleoprotein R isoform X8

    12. XM_047424843.1XP_047280799.1  heterogeneous nuclear ribonucleoprotein R isoform X7

    13. XM_047424994.1XP_047280950.1  heterogeneous nuclear ribonucleoprotein R isoform X11

    14. XM_011540472.4XP_011538774.2  heterogeneous nuclear ribonucleoprotein R isoform X10

    15. XM_047424719.1XP_047280675.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    16. XM_047424699.1XP_047280655.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_014040926.1 Reference GRCh38.p14 PATCHES

      Range
      74667..114263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331911.1XP_054187886.1  heterogeneous nuclear ribonucleoprotein R isoform X14

    2. XM_054331912.1XP_054187887.1  heterogeneous nuclear ribonucleoprotein R isoform X15

    3. XM_054331910.1XP_054187885.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0
    4. XM_054331908.1XP_054187883.1  heterogeneous nuclear ribonucleoprotein R isoform X12

    5. XM_054331909.1XP_054187884.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0
    6. XM_054331905.1XP_054187880.1  heterogeneous nuclear ribonucleoprotein R isoform X6

      UniProtKB/Swiss-Prot
      O43390, Q2L7G6, Q5TEH1, Q9BV64, S4R3J4
    7. XM_054331904.1XP_054187879.1  heterogeneous nuclear ribonucleoprotein R isoform X5

    8. XM_054331903.1XP_054187878.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    9. XM_054331902.1XP_054187877.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    10. XM_054331906.1XP_054187881.1  heterogeneous nuclear ribonucleoprotein R isoform X9

    11. XM_054331907.1XP_054187882.1  heterogeneous nuclear ribonucleoprotein R isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23137824..23177454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333767.1XP_054189742.1  heterogeneous nuclear ribonucleoprotein R isoform X14

    2. XM_054333768.1XP_054189743.1  heterogeneous nuclear ribonucleoprotein R isoform X15

    3. XM_054333766.1XP_054189741.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0
    4. XM_054333764.1XP_054189739.1  heterogeneous nuclear ribonucleoprotein R isoform X12

    5. XM_054333765.1XP_054189740.1  heterogeneous nuclear ribonucleoprotein R isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHG0
    6. XM_054333761.1XP_054189736.1  heterogeneous nuclear ribonucleoprotein R isoform X6

      UniProtKB/Swiss-Prot
      O43390, Q2L7G6, Q5TEH1, Q9BV64, S4R3J4
    7. XM_054333760.1XP_054189735.1  heterogeneous nuclear ribonucleoprotein R isoform X5

    8. XM_054333759.1XP_054189734.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    9. XM_054333758.1XP_054189733.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    10. XM_054333762.1XP_054189737.1  heterogeneous nuclear ribonucleoprotein R isoform X9

    11. XM_054333763.1XP_054189738.1  heterogeneous nuclear ribonucleoprotein R isoform X17