CDH17 cadherin 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDH17provided by HGNC
Official Full Name: cadherin 17provided by HGNC
Primary source: HGNC:HGNC:1756
See related: Ensembl:ENSG00000079112 MIM:603017; AllianceGenome:HGNC:1756
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPT1; CDH16; HPT-1
Summary: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression: Biased expression in duodenum (RPKM 145.2), small intestine (RPKM 127.8) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q22.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (94127162..94217278, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (95252073..95342140, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (95139390..95229506, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cadherin-17 (CDH17) expression in human cancer: A tissue microarray study on 18,131 tumors.
Title: Cadherin-17 (CDH17) expression in human cancer: A tissue microarray study on 18,131 tumors.
Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.
Title: Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.
The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population.
Title: The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population.
CDH17+/CDX2+ Can be Helpful in Providing Support for Small Intestinal Origin Versus Pancreatic or Biliary Origin.
Title: CDH17+/CDX2+ Can be Helpful in Providing Support for Small Intestinal Origin Versus Pancreatic or Biliary Origin.
Mechanism of dimerization and structural features of human LI-cadherin.
Title: Mechanism of dimerization and structural features of human LI-cadherin.
A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.
Title: A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.
Clinical correlation of cadherin-17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma.
Title: Clinical correlation of cadherin-17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma.
Combined use of LI-cadherin and CDX2 can improve the accuracy in the diagnosis of metastatic adenocarcinoma cells in serous cavity effusion and provide some bases of histologic origin because of their high sensitivity and specificity.
Title: LI-cadherin and CDX2: Useful Markers in Metastatic Gastrointestinal Adenocarcinoma Cells in Serous Cavity Effusion.
immunophenotyping with CLDN18, CDH17, and PAX8 might improve the diagnostic accuracy of histopathological classifications of endocervical adenocarcinoma
Title: Immunophenotype analysis using CLDN18, CDH17, and PAX8 for the subcategorization of endocervical adenocarcinomas in situ: gastric-type, intestinal-type, gastrointestinal-type, and Müllerian-type.
CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways.
Title: Disruption of oncogenic liver-intestine cadherin (CDH17) drives apoptotic pancreatic cancer death.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G59414 (e-PCR)
- UniSTS:136725

RH120584 (e-PCR)
- UniSTS:132417

STS-X83228 (e-PCR)
- UniSTS:27202

G54631 (e-PCR)
- UniSTS:117832

CDH17_522 (e-PCR)
- UniSTS:277085

SGC35251 (e-PCR)
- UniSTS:69832

STS-T76997 (e-PCR)
- UniSTS:57556

D8S1083 (e-PCR)
- UniSTS:35807

D8S1071 (e-PCR)
- UniSTS:64748

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in germinal center B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in marginal zone B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligopeptide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spleen development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cadherin-17

Names: HPT-1 cadherin; LI cadherin; cadherin 17, LI cadherin (liver-intestine); cadherin-16; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; liver-intestine cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144663.2 → NP_001138135.1 cadherin-17 isoform 1 precursor

See identical proteins and their annotated locations for NP_001138135.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK312873, AP003351, BF591263, U07969, X83228

Consensus CDS

CCDS6260.1

UniProtKB/Swiss-Prot

Q12864, Q15336, Q2M2E0

Related

ENSP00000401468.2, ENST00000450165.6

Conserved Domains (3) summary

cd11304
Location:570 → 663

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:271 → 338

CA; Cadherin repeats

cl29226
Location:681 → 765

Cadherin; Cadherin domain
NM_001413951.1 → NP_001400880.1 cadherin-17 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413952.1 → NP_001400881.1 cadherin-17 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478

UniProtKB/Swiss-Prot

Q12864, Q15336, Q2M2E0
NM_001413953.1 → NP_001400882.1 cadherin-17 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478

UniProtKB/Swiss-Prot

Q12864, Q15336, Q2M2E0
NM_001413954.1 → NP_001400883.1 cadherin-17 isoform 3

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413955.1 → NP_001400884.1 cadherin-17 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413956.1 → NP_001400885.1 cadherin-17 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413957.1 → NP_001400886.1 cadherin-17 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413958.1 → NP_001400887.1 cadherin-17 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413959.1 → NP_001400888.1 cadherin-17 isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413960.1 → NP_001400889.1 cadherin-17 isoform 9

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_001413961.1 → NP_001400890.1 cadherin-17 isoform 10

Status: REVIEWED

Source sequence(s)

AP003351, AP003478
NM_004063.4 → NP_004054.3 cadherin-17 isoform 1 precursor

See identical proteins and their annotated locations for NP_004054.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AP003351, BF591263, DB009107, U07969, X83228

Consensus CDS

CCDS6260.1

UniProtKB/Swiss-Prot

Q12864, Q15336, Q2M2E0

Related

ENSP00000027335.3, ENST00000027335.8

Conserved Domains (3) summary

cd11304
Location:570 → 663

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:271 → 338

CA; Cadherin repeats

cl29226
Location:681 → 765

Cadherin; Cadherin domain