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    MIR7-3HG MIR7-3 host gene [ Homo sapiens (human) ]

    Gene ID: 284424, updated on 22-Oct-2024

    Summary

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    Official Symbol
    MIR7-3HGprovided by HGNC
    Official Full Name
    MIR7-3 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:30049
    See related
    Ensembl:ENSG00000176840 AllianceGenome:HGNC:30049
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Huh7; PGSF1; C19orf30; LINC00306; NCRNA00306; uc002mbe.2
    Expression
    Biased expression in brain (RPKM 5.9), testis (RPKM 2.8) and 4 other tissues See more
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    Genomic context

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    See MIR7-3HG in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4769105..4772556)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4754678..4758129)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4769117..4772568)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9904 Neighboring gene tRNA-Gly (anticodon TCC) 1-1 Neighboring gene tRNA-Val (anticodon CAC) 3-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4738040-4738540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4738541-4739041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4742625-4743225 Neighboring gene Sharpr-MPRA regulatory region 10046 Neighboring gene Sharpr-MPRA regulatory region 15136 Neighboring gene microRNA 7-3 Neighboring gene MPRA-validated peak3287 silencer Neighboring gene uncharacterized LOC124904620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4791399-4792056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792057-4792713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792714-4793370 Neighboring gene fem-1 homolog A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway. Mao X, et al. Biochem Biophys Res Commun, 2023 Mar 5. PMID 36731335
    2. Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. Yang H, et al. Biochem Pharmacol, 2013 Jun 15. PMID 23643933, Free PMC Article
    3. Expression profile of active genes in the human pituitary gland. Tanaka S, et al. J Mol Endocrinol, 2002 Feb. PMID 11854097
    4. MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1. Capizzi M, et al. Autophagy, 2017 Mar 4. PMID 28059583, Free PMC Article
    5. MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. Wang F, et al. Tumour Biol, 2016 Aug. PMID 26831666

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic beta-cells through the PI3K/AKT signaling pathway.
      Title: A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway.
    2. These data suggest a new and interesting role of MIR7-3HG as an anti-autophagic MIRNA that may affect oncogenesis through the regulation of the tumor suppressor AMBRA1.
      Title: MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1.
    3. miR-7-KLF4-VEGF signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells , suggesting that miR-7 is a potential agent for the development of anti-angiogenic therapeutics in vascular diseases and solid tumors
      Title: Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4.
    4. Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma
      Title: MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis.
    5. These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway.
      Title: MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • MIR7-3 host gene (non-protein coding)
    • long intergenic non-protein coding RNA 306
    • pituitary gland specific factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027148.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB058892, AB058893, BC117294, BE671262, DB051621
      Related
      ENST00000317292.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4769105..4772556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4754678..4758129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_174947.2: Suppressed sequence

      Description
      NM_174947.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6C7.1 GenPept UniProtKB/Swiss-Prot:Q8N6C7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials