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    AZGP1 alpha-2-glycoprotein 1, zinc-binding [ Homo sapiens (human) ]

    Gene ID: 563, updated on 10-Dec-2024

    Summary

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    Official Symbol
    AZGP1provided by HGNC
    Official Full Name
    alpha-2-glycoprotein 1, zinc-bindingprovided by HGNC
    Primary source
    HGNC:HGNC:910
    See related
    Ensembl:ENSG00000160862 MIM:194460; AllianceGenome:HGNC:910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAG; ZA2G
    Summary
    Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. Implicated in prostate carcinoma. Biomarker of several diseases, including gastrointestinal system cancer (multiple); kidney failure (multiple); liver cirrhosis; lung adenocarcinoma; and obesity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AZGP1 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99966730..99976031, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101206237..101220128, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99564353..99573654, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99526456-99527041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99527042-99527626 Neighboring gene gap junction protein gamma 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99541581-99542436 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99543294-99544149 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99580686-99580841 Neighboring gene AZGP1 pseudogene 1 Neighboring gene gap junction protein gamma 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Role of adipokine zinc-α(2)-glycoprotein in coronary heart disease. Huang D, et al. Am J Physiol Endocrinol Metab, 2019 Dec 1. PMID 31526290
    2. Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism. Xiao XH, et al. BMC Endocr Disord, 2019 Jan 22. PMID 30670019, Free PMC Article
    3. ZAG Regulates the Skin Barrier and Immunity in Atopic Dermatitis. Noh JY, et al. J Invest Dermatol, 2019 Aug. PMID 30738053
    4. AZGP1 is androgen responsive and involved in AR-induced prostate cancer cell proliferation and metastasis. Cao R, et al. J Cell Physiol, 2019 Aug. PMID 30820960
    5. Circulating zinc-α2-glycoprotein is reduced in women with polycystic ovary syndrome, but can be increased by exenatide or metformin treatment. Zheng S, et al. Endocr J, 2019 Jun 28. PMID 30918134

    See all (209) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
      Title: Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
    2. AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
      Title: AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
    3. RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD.
      Title: RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD.
    4. AZGP1 deficiency promotes angiogenesis in prostate cancer.
      Title: AZGP1 deficiency promotes angiogenesis in prostate cancer.
    5. Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
      Title: Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
    6. Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
      Title: Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
    7. Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
      Title: Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
    8. CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
      Title: CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
    9. Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc alpha2-Glycoprotein and Associated Genes in Obesity.
      Title: Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc α2-Glycoprotein and Associated Genes in Obesity.
    10. Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
      Title: Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
    Submit: New GeneRIF Correction See all GeneRIFs (106)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA nuclease activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    zinc-alpha-2-glycoprotein
    Names
    Alpha-2-glycoprotein, zinc
    Zn-alpha2-glycoprotein
    testicular tissue protein Li 227
    zn-alpha-2-GP
    zn-alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185.4 → NP_001176.1  zinc-alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_001176.1

      Status: VALIDATED

      Source sequence(s)
      BC005306, BC033830
      Consensus CDS
      CCDS5680.1
      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
      Related
      ENSP00000292401.4, ENST00000292401.9
      Conserved Domains (2) summary
      cd07698
      Location:205 → 296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 → 201
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99966730..99976031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101206237..101220128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358658.1 → XP_054214633.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00

    2. XM_054358657.1 → XP_054214632.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25311.2 GenPept UniProtKB/Swiss-Prot:P25311

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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