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    Glipr1 GLI pathogenesis related 1 [ Mus musculus (house mouse) ]

    Gene ID: 73690, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Glipr1provided by MGI
    Official Full Name
    GLI pathogenesis related 1provided by MGI
    Primary source
    MGI:MGI:1920940
    See related
    Ensembl:ENSMUSG00000056888 AllianceGenome:MGI:1920940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RTVP1; RTVP-1; gliPR 1; mRTVP-1; 2410114O14Rik
    Summary
    Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Orthologous to human GLIPR1 (GLI pathogenesis related 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.1), placenta adult (RPKM 15.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glipr1 in Genome Data Viewer
    Location:
    10 D2; 10 59.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111821353..111838539, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111985448..112002639, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27889 Neighboring gene STARR-seq mESC enhancer starr_27890 Neighboring gene STARR-seq mESC enhancer starr_27891 Neighboring gene predicted gene, 20758 Neighboring gene STARR-seq mESC enhancer starr_27892 Neighboring gene STARR-seq mESC enhancer starr_27894 Neighboring gene STARR-positive B cell enhancer mm9_chr10:111362554-111362854 Neighboring gene STARR-positive B cell enhancer ABC_E5182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:111409583-111409851 Neighboring gene STARR-seq mESC enhancer starr_27895 Neighboring gene STARR-positive B cell enhancer ABC_E2340 Neighboring gene STARR-positive B cell enhancer ABC_E1813 Neighboring gene KRR1, small subunit (SSU) processome component, homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3914 Neighboring gene calcyphosphine 2 pseudogene Neighboring gene GLI pathogenesis-related 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice. Friend N, et al. PLoS One, 2020. PMID 31995627, Free PMC Article
    2. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Sheng X, et al. Mol Cancer, 2016 Mar 18. PMID 26988096, Free PMC Article
    3. Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models. Fujita T, et al. Urol Oncol, 2014 Feb. PMID 23433894, Free PMC Article
    4. Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1. Palaniswamy R, et al. BMC Mol Biol, 2010 Apr 30. PMID 20433698, Free PMC Article
    5. GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling. Peng W, et al. Int J Chron Obstruct Pulmon Dis, 2021. PMID 34675506, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
      Title: GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
    2. Collectively, this study characterizes multimeric protein complexes on the sperm surface and identifies GLIPRL1L1 as a physiologically relevant regulator of IZUMO1 function and the fertilization process.
      Title: GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.
    3. Results find that Glipr1 expression is lost in the 5TGM1 murine multiple myeloma (MM) cell line. Its overexpression in a HMCL/5TGM1 cells did not significantly alter tumor cell growth in vitro or in vivo. These results suggest that GLIPR1 is unlikely to be a potent tumor suppressor in multiple myeloma.
      Title: GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.
    4. This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth.
      Title: GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
    5. Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors.
      Title: Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.
    6. The genetic variation is a key determining factor for the alternative splicing events in the Gli1 5' UTRs, which have functional implications on translational efficiency.
      Title: Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.
    7. Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1)
      Title: mRTVP-1, a novel p53 target gene with proapoptotic activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glioma pathogenesis-related protein 1
    Names
    GLI pathogenesis-related 1 (glioma)
    related to testes-specific, vespid, and pathogenesis proteins

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028608.3 → NP_082884.1  glioma pathogenesis-related protein 1 precursor

      See identical proteins and their annotated locations for NP_082884.1

      Status: VALIDATED

      Source sequence(s)
      BB869923, BC098231, BY540964
      Consensus CDS
      CCDS24169.1
      UniProtKB/Swiss-Prot
      Q9CWG1
      UniProtKB/TrEMBL
      Q4QQK5
      Related
      ENSMUSP00000074359.6, ENSMUST00000074805.12
      Conserved Domains (1) summary
      cd05385
      Location:32 → 167
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111821353..111838539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514218.5 → XP_006514281.1  glioma pathogenesis-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514281.1

      Conserved Domains (1) summary
      cd05385
      Location:32 → 168
      CAP_GLIPR1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins

    2. XM_006514217.5 → XP_006514280.1  glioma pathogenesis-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514280.1

      Conserved Domains (1) summary
      cd05385
      Location:32 → 168
      CAP_GLIPR1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWG1.1 GenPept UniProtKB/Swiss-Prot:Q9CWG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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