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    Rab37 RAB37, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 58222, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Rab37provided by MGI
    Official Full Name
    RAB37, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1929945
    See related
    Ensembl:ENSMUSG00000020732 AllianceGenome:MGI:1929945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230331O03Rik; B230354I04Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in protein transport. Located in secretory granule. Is expressed in brain and retina. Orthologous to human RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 5.8), frontal lobe adult (RPKM 3.4) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab37 in Genome Data Viewer
    Location:
    11 E2; 11 80.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114982257..115053066)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115091331..115162773)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31142 Neighboring gene CD300 molecule like family member D3 Neighboring gene CD300E molecule Neighboring gene STARR-seq mESC enhancer starr_31143 Neighboring gene STARR-seq mESC enhancer starr_31145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114966559-114966859 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114967952-114968253 Neighboring gene CD300 molecule like family member F Neighboring gene STARR-positive B cell enhancer ABC_E11499 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115019296-115019604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115024157-115024344 Neighboring gene STARR-positive B cell enhancer ABC_E91 Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115048516-115048817 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Secretory autophagy-promoted cargo exocytosis requires active RAB37. Wu SY, et al. Autophagy, 2024 Apr. PMID 37151129, Free PMC Article
    2. Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1. Huang H, et al. Stem Cell Rev Rep, 2023 May. PMID 36627432
    3. Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer. Kuo WT, et al. J Biomed Sci, 2024 Feb 7. PMID 38321486, Free PMC Article
    4. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1. Wu SY, et al. J Biomed Sci, 2022 Dec 2. PMID 36457117, Free PMC Article
    5. Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Wu SY, et al. Autophagy, 2023 Apr. PMID 36109708, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Secretory autophagy-promoted cargo exocytosis requires active RAB37.
      Title: Secretory autophagy-promoted cargo exocytosis requires active RAB37.
    2. Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
      Title: Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
    3. Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90alpha and TIMP1.
      Title: Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1.
    4. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
      Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
    5. Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
      Title: Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
    6. RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
      Title: Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
    7. Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages
      Title: Release of TNF-α from macrophages is mediated by small GTPase Rab37.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC157622

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-related protein Rab-37
    Names
    GTPase Rab37
    RAB37, member of RAS oncogene family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163753.1 → NP_001157225.1  ras-related protein Rab-37 isoform 2

      See identical proteins and their annotated locations for NP_001157225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end, and is missing two in-frame coding exons compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK046260, BB084455
      Consensus CDS
      CCDS48979.1
      UniProtKB/TrEMBL
      Q8BQX0
      Related
      ENSMUSP00000065016.5, ENSMUST00000067754.11
      Conserved Domains (1) summary
      cd04112
      Location:23 → 213
      Rab26; Rab GTPase family 26 (Rab26)

    2. NM_021411.4 → NP_067386.3  ras-related protein Rab-37 isoform 1

      See identical proteins and their annotated locations for NP_067386.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK040216, AK050483, BB084455, BY131048
      Consensus CDS
      CCDS25620.1
      UniProtKB/Swiss-Prot
      Q8C7E1, Q9JKM7
      UniProtKB/TrEMBL
      Q544E8
      Related
      ENSMUSP00000021076.6, ENSMUST00000021076.6
      Conserved Domains (1) summary
      cd04112
      Location:31 → 220
      Rab26; Rab GTPase family 26 (Rab26)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114982257..115053066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156872.1 → XP_036012765.1  ras-related protein Rab-37 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:31 → 144
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_003949483.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKM7.2 GenPept UniProtKB/Swiss-Prot:Q9JKM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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