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    MAP9 microtubule associated protein 9 [ Homo sapiens (human) ]

    Gene ID: 79884, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MAP9provided by HGNC
    Official Full Name
    microtubule associated protein 9provided by HGNC
    Primary source
    HGNC:HGNC:26118
    See related
    Ensembl:ENSG00000164114 MIM:610070; AllianceGenome:HGNC:26118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASAP
    Summary
    ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in brain (RPKM 7.7), thyroid (RPKM 7.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP9 in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155342658..155376965, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158674560..158709763, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156263810..156298117, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y2 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22081 Neighboring gene TBC1 domain family member 3C pseudogene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma. Xiao H, et al. Virus Res, 2021 Feb. PMID 33309912
    2. MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population. Liu W, et al. Acta Virol, 2018. PMID 30472874
    3. MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement. Tran MV, et al. Dev Cell, 2024 Jan 22. PMID 38159567,
    4. ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. Saffin JM, et al. Proc Natl Acad Sci U S A, 2005 Aug 9. PMID 16049101, Free PMC Article
    5. ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Venoux M, et al. Hum Mol Genet, 2008 Jan 15. PMID 17925329

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement.
      Title: MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement.
    2. Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
      Title: Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
    3. MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.
      Title: MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.
    4. MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
      Title: MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
    5. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.
      Title: Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.
    6. Data suggest miR-320a/microtubule-associated protein 9 (MAP9) as promising targets for the treatment and prevention of postmenopausal osteoporosis (PMO).
      Title: MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K/AKT signaling pathway.
    7. MAP9 rs1058992 polymorphism is associated with risk of EBV-associated gastric carcinoma
      Title: MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population.
    8. MAP9 downregulation is associated with colorectal malignancy.
      Title: Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
    9. ASAP stabilizes p53 both by alleviating MDM2-mediated p53 ubiquitination and by enhancing its p300-dependent acetylation.
      Title: Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage.
    10. Results highlight dual ASAP regulation by Plk1 and further confirm the importance of ASAP for spindle pole organization, bipolar spindle assembly, and mitosis.
      Title: Plk1 regulates both ASAP localization and its role in spindle pole integrity.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated protein 9
    Names
    aster-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039580.2 → NP_001034669.1  microtubule-associated protein 9

      See identical proteins and their annotated locations for NP_001034669.1

      Status: VALIDATED

      Source sequence(s)
      AC097467, AY690636, BC022852, CF144347
      Consensus CDS
      CCDS35493.1
      UniProtKB/Swiss-Prot
      Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
      UniProtKB/TrEMBL
      B9EJB6
      Related
      ENSP00000310593.4, ENST00000311277.9
      Conserved Domains (1) summary
      cl01868
      Location:521 → 597
      YukC; WXG100 protein secretion system (Wss), protein YukC

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      155342658..155376965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532255.4 → XP_011530557.1  microtubule-associated protein 9 isoform X3

      UniProtKB/TrEMBL
      B9EJB6
      Conserved Domains (1) summary
      cl01868
      Location:449 → 525
      YukC; WXG100 protein secretion system (Wss), protein YukC

    2. XM_011532254.2 → XP_011530556.1  microtubule-associated protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011530556.1

      UniProtKB/Swiss-Prot
      Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
      UniProtKB/TrEMBL
      B9EJB6
      Conserved Domains (1) summary
      cl01868
      Location:521 → 597
      YukC; WXG100 protein secretion system (Wss), protein YukC

    3. XM_017008616.2 → XP_016864105.1  microtubule-associated protein 9 isoform X2

      UniProtKB/TrEMBL
      B9EJB6
      Conserved Domains (2) summary
      PTZ00121
      Location:280 → 620
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:506 → 591
      PRK12704; phosphodiesterase; Provisional

    4. XM_011532253.2 → XP_011530555.1  microtubule-associated protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011530555.1

      UniProtKB/Swiss-Prot
      Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
      UniProtKB/TrEMBL
      B9EJB6
      Conserved Domains (1) summary
      cl01868
      Location:521 → 597
      YukC; WXG100 protein secretion system (Wss), protein YukC

    5. XM_017008617.2 → XP_016864106.1  microtubule-associated protein 9 isoform X2

      UniProtKB/TrEMBL
      B9EJB6
      Conserved Domains (2) summary
      PTZ00121
      Location:280 → 620
      PTZ00121; MAEBL; Provisional
      PRK12704
      Location:506 → 591
      PRK12704; phosphodiesterase; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      158674560..158709763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350850.1 → XP_054206825.1  microtubule-associated protein 9 isoform X3

      UniProtKB/TrEMBL
      B9EJB6

    2. XM_054350847.1 → XP_054206822.1  microtubule-associated protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
      UniProtKB/TrEMBL
      B9EJB6

    3. XM_054350848.1 → XP_054206823.1  microtubule-associated protein 9 isoform X2

      UniProtKB/TrEMBL
      B9EJB6

    4. XM_054350846.1 → XP_054206821.1  microtubule-associated protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
      UniProtKB/TrEMBL
      B9EJB6

    5. XM_054350849.1 → XP_054206824.1  microtubule-associated protein 9 isoform X2

      UniProtKB/TrEMBL
      B9EJB6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024826.1: Suppressed sequence

      Description
      NM_024826.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49MG5.3 GenPept UniProtKB/Swiss-Prot:Q49MG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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