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    zhx3b zinc fingers and homeoboxes 3b [ Danio rerio (zebrafish) ]

    Gene ID: 386659, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zhx3bprovided by ZNC
    Official Full Name
    zinc fingers and homeoboxes 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031107-1
    See related
    Ensembl:ENSDARG00000019774 AllianceGenome:ZFIN:ZDB-GENE-031107-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tix1; zhx3; zgc:110489
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human ZHX3 (zinc fingers and homeoboxes 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zhx3b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2872855..2900839, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2929163..2957268, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase Ib Neighboring gene phospholipase C, gamma 1 Neighboring gene RAB5 interacting factor Neighboring gene DEAH-box helicase 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan D, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925734, Free PMC Article
    2. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    3. Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung. Zheng W, et al. PLoS One, 2011. PMID 21887364, Free PMC Article
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc fingers and homeoboxes protein 3
    Names
    triple homeobox 1
    zinc fingers and homeoboxes 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198813.1 → NP_942108.1  zinc fingers and homeoboxes protein 3

      See identical proteins and their annotated locations for NP_942108.1

      Status: PROVISIONAL

      Source sequence(s)
      AY311506
      UniProtKB/TrEMBL
      Q6W5B5
      Related
      ENSDARP00000005108.5, ENSDART00000022413.6
      Conserved Domains (2) summary
      smart00389
      Location:607 → 660
      HOX; Homeodomain
      cd00086
      Location:895 → 952
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      2872855..2900839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296583.4 → XP_009294858.1  zinc fingers and homeoboxes protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B5V6, F1QQ52
      Related
      ENSDARP00000141318.1, ENSDART00000165955.2
      Conserved Domains (2) summary
      smart00389
      Location:607 → 660
      HOX; Homeodomain
      cd00086
      Location:895 → 952
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_009296582.4 → XP_009294857.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AMK8, F1R0G0
      Conserved Domains (2) summary
      smart00389
      Location:607 → 660
      HOX; Homeodomain
      cd00086
      Location:895 → 952
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein Strain
    Heading Accession and Version

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